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| | kaempferol 3-O-sophoroside Basic information |
| Product Name: | kaempferol 3-O-sophoroside | | Synonyms: | kaempferol 3-O-sophoroside;3-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-4',5,7-trihydroxyflavone;3-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-4',5,7-trihydroxyflavone;Kaempferol 3-β-sophoroside;Sophoraflavanoloside;3-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Kaempferol 3-O-beta-D-sophoroside | | CAS: | 19895-95-5 | | MF: | C27H30O16 | | MW: | 610.52 | | EINECS: | | | Product Categories: | | | Mol File: | 19895-95-5.mol |  |
| | kaempferol 3-O-sophoroside Chemical Properties |
| Melting point | 194-198℃ | | Boiling point | 995.0±65.0 °C(Predicted) | | density | 1.82 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly) | | pka | 6.20±0.40(Predicted) | | form | Solid | | color | Light Yellow | | InChIKey | LKZDFKLGDGSGEO-CCMCOHMBNA-N |
| Toxicity | LD50 intraperitoneal in mouse: > 1gm/kg |
| | kaempferol 3-O-sophoroside Usage And Synthesis |
| Chemical Properties | Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from mulberry leaves, Hedyotis diffusa, and roses. | | Uses | Kaempferol 3-β-Sophoroside is a derivative of Kaempferol (K100000), a plant flavonoid which play a beneficial role in human health promotion. | | Definition | ChEBI: A kaempferol O-glucoside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage. | | in vivo | Kaempferol 3-O-sophoroside (10 and 20 mg/kg, p.o., once daily for 20 days) binds to AMP-activated protein kinase (AMPK) to promote brain-derived neurotrophic factor (BDNF) production and autophagy enhancement in corticosterone (HY-B1618)-induced mouse depression model and chronic unpredictable mild stress (CUMS) model, ultimately achieving antidepressant effects[3].
Kaempferol 3-O-sophoroside (100 and 200 mg/kg, p.o., 30-minute administration duration) exhibits analgesic effects in the acetic acid-induced writhing mice model[4]. | Animal Model: | Acetic acid-induced writhing mice model[4] | | Dosage: | 50, 100, 200 mg/kg | | Administration: | Oral gavage (p.o.), administration duration of 30 minutes | | Result: | Caused dose-dependent inhibition of the writhing response induced by acetic acid. |
| Animal Model: | Corticosterone (HY-B1618)-induced mouse depression model; Chronic unpredictable mild stress (CUMS) model[3] | | Dosage: | 10 and 20 mg/kg | | Administration: | Oral gavage (p.o.), once per day for 20 consecutive days | | Result: | Ameliorated weight loss, dyskinesia, and hippocampal volume reduction induced by Corticosterone and CUMS. |
| | IC 50 | TLR2; TLR4 |
| | kaempferol 3-O-sophoroside Preparation Products And Raw materials |
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