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| | 1-Chloro-3-iodobenzene Basic information |
| | 1-Chloro-3-iodobenzene Chemical Properties |
| Melting point | 95-96 °C | | Boiling point | 103-104 °C15 mm Hg(lit.) | | density | 1.926 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.631(lit.) | | Fp | 215 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Liquid | | Specific Gravity | 1.926 | | color | Clear light yellow | | Water Solubility | Soluble in water 67.2 mg/L. | | Sensitive | Light Sensitive | | BRN | 1904539 | | InChI | 1S/C6H4ClI/c7-5-2-1-3-6(8)4-5/h1-4H | | InChIKey | JMLWXCJXOYDXRN-UHFFFAOYSA-N | | SMILES | Clc1cccc(I)c1 | | CAS DataBase Reference | 625-99-0(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1-chloro-3-iodo-(625-99-0) | | EPA Substance Registry System | Benzene, 1-chloro-3-iodo- (625-99-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29039990 | | Storage Class | 10 - Combustible liquids |
| | 1-Chloro-3-iodobenzene Usage And Synthesis |
| Chemical Properties | Clear light yellow liquid | | Uses | suzuki reaction | | Uses | 1-Chloro-3-iodobenzene is used as a pharmaceutical intermediate. | | Synthesis Reference(s) | Synthetic Communications, 11, p. 639, 1981 DOI: 10.1080/00397918108063637 | | General Description | The multiple-quantum proton NMR spectra of 3-chloroiodobenzene was studied. | | Synthesis | General procedure for the synthesis of m-chloroiodobenzene from 3-chlorophenylboronic acid: a mixture of arylboronic acid (0.55 mmol), KF (96 mg, 1.65 mmol) and I2 (127 mg, 0.50 mmol) in 1,4-dioxane (5 mL) was stirred and reacted for 1 hr at 80 °C. After completion of the reaction, the mixture was filtered through a silica gel column and eluted with ether (10 mL). Subsequently, the solvent was removed by rotary evaporator. For further purification, the target product, m-chloroiodobenzene, was isolated by silica gel column chromatography using petroleum ether/ether (98:2) as eluent. | | References | [1] Chemistry - A European Journal, 2011, vol. 17, # 20, p. 5652 - 5660
[2] Tetrahedron Letters, 2015, vol. 56, # 9, p. 1122 - 1123
[3] Synlett, 1998, # 2, p. 141 - 142
[4] Synlett, 2014, vol. 25, # 7, p. 995 - 1000 |
| | 1-Chloro-3-iodobenzene Preparation Products And Raw materials |
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