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N-BOC-4-Hydroxypiperidine

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N-BOC-4-Hydroxypiperidine Basic information
Product Name:N-BOC-4-Hydroxypiperidine
Synonyms:1-Boc-4-piperidinol, tert-Butyl 4-hydroxy-1-piperidinecarboxylate;N-BOC-4-Hydroxypiperidine,97%;1-Boc-4-hydroxypiperidine ,98%;N-Boc-4hydropiperidine;1-(tert-Butoxycarbonyl)-4-hydroxypiperidine, tert-Butyl 4-hydroxypiperidine-1-carboxylate;N-Boc-4-hydroxy-1-piperidine;tert-butyl 4-hydroxypiperidin-1-carboxylate;1-Boc -4-hydroxypeiperidine
CAS:109384-19-2
MF:C10H19NO3
MW:201.26
EINECS:600-916-6
Product Categories:Heterocyclic Compounds;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Alcohols and Derivatives;Amines and Anilines;Piperidines;Pyrans, Piperidines & Piperazines
Mol File:109384-19-2.mol
N-BOC-4-Hydroxypiperidine Structure
N-BOC-4-Hydroxypiperidine Chemical Properties
Melting point 61-65 °C (lit.)
Boiling point 292.3±33.0 °C(Predicted)
density 1.107±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
pka14.80±0.20(Predicted)
form Powder
color White to cream
BRN 7202094
InChIInChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3
InChIKeyPWQLFIKTGRINFF-UHFFFAOYSA-N
SMILESN1(C(OC(C)(C)C)=O)CCC(O)CC1
CAS DataBase Reference109384-19-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
N-BOC-4-Hydroxypiperidine Usage And Synthesis
Chemical PropertiesWhite to cream powder
UsesN-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.
UsesUsed in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.
PreparationA mixture of 4-hydroxypiperidine (10.0 g, 98. 9 mmol), aqueous sodiumhydrogen carbonate (150 mL, 1 M), DI-FERT-BUTYL dicarbonate (21. 6 g, 98.9 mmol) and dichloromethane was stirred for 15 h. The phases were separated and the product (N-BOC-4-Hydroxypiperidine) was isolated as an oil in quantitative yield (19.9 g).
N-BOC-4-Hydroxypiperidine
Tag:N-BOC-4-Hydroxypiperidine(109384-19-2) Related Product Information
tert-Butyl 4-methylenepiperidine-1-carboxylate N-Boc-4-piperidinemethanol 1-Boc-4-cyanopiperidine Haloperidol N-Carbobenzyloxyglycine tert-Butyl peroxyacetate Triacetonediamine tert-Butyl acetate 4-Cyanophenol DROPERIDOL 1-Boc-3-piperidone 2,2,6,6-Tetramethyl-4-piperidinol tert-Butanol Diphenoxylate Carbonyl iron powder 4-Hydroxypiperidine (2R,4S)-N-Boc-4-hydroxypiperidine-2-carboxylic acid methyl ester 1-Boc-4-methanesulfonyloxypiperidine