Mal-PEG4-amine TFA salt manufacturers
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| | Mal-PEG4-amine TFA salt Basic information |
| Product Name: | Mal-PEG4-amine TFA salt | | Synonyms: | Mal-PEG4-C2-NH2 TFA;Mal-PEG5-amine;1-(14-amino-3,6,9,12-tetraoxatetradecyl)pyrrolidine-2,5-dione 2,2,2-trifluoroacetate;1-(14-Amino-3,6,9,12-tetraoxatetradecyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate | | CAS: | 2512227-13-1 | | MF: | C16H25F3N2O8 | | MW: | 430.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2512227-13-1.mol |  |
| | Mal-PEG4-amine TFA salt Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Mal-PEG4-amine TFA salt Usage And Synthesis |
| Uses | Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Mal-PEG4-amine TFA salt Preparation Products And Raw materials |
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