- Mal-PEG1-COOtBu
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2025-06-07
- CAS:810677-16-8
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Mal-PEG1-t-butyl ester Basic information |
| Product Name: | Mal-PEG1-t-butyl ester | | Synonyms: | Mal-PEG1-t-butyl ester;Mal-PEG1-Boc;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 1,1-dimethylethyl ester;tert-butyl 3-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoate | | CAS: | 810677-16-8 | | MF: | C13H19NO5 | | MW: | 269.29 | | EINECS: | | | Product Categories: | | | Mol File: | 810677-16-8.mol |  |
| | Mal-PEG1-t-butyl ester Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Solid | | color | White to off-white |
| | Mal-PEG1-t-butyl ester Usage And Synthesis |
| Description | Mal-PEG1-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Uses | Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-PEG1-t-butyl ester Preparation Products And Raw materials |
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