- 5-Amino-2-bromopyridine
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- $0.00 / 25KG
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2025-12-01
- CAS:13534-97-9
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
- 5-Amino-2-bromopyridine
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- $1.10 / 1g
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2025-11-18
- CAS:13534-97-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 5-Amino-2-bromopyridine
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- $5.00 / 1KG
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2025-09-25
- CAS:13534-97-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | 5-Amino-2-bromopyridine Basic information |
| | 5-Amino-2-bromopyridine Chemical Properties |
| Melting point | 75 °C | | Boiling point | 180 °C | | density | 1.6065 (rough estimate) | | refractive index | 1.5182 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | Powder | | pka | 1.87±0.10(Predicted) | | color | Beige to brown-black | | BRN | 109102 | | InChI | InChI=1S/C5H5BrN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2 | | InChIKey | XTHKRYHULUJQHN-UHFFFAOYSA-N | | SMILES | C1=NC(Br)=CC=C1N | | CAS DataBase Reference | 13534-97-9(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-Amino-2-bromopyridine Usage And Synthesis |
| Chemical Properties | Light yellow needles | | Uses | 3-Amino-6-bromopyridine may undergo polymerization via Buchwald–Hartwig amination in the presence of sodium tert-butoxide and XPhos(2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl) ligand yielding para-linked and meta-linked polyaminopyridines. | | General Description | 3-Amino-6-bromopyridine can be synthesized via bromination of 3-aminopyridine using N-bromosuccinimide in acetonitrile. | | Synthesis | General procedure for the synthesis of 5-amino-2-bromopyridine from 2-bromo-5-nitropyridine: To a solution of 2-bromo-5-nitropyridine (2.03 g, 10 mmol) in ethanol (48 mL) was added sequentially iron powder (2.8 g, 50 mmol), concentrated hydrochloric acid (1.9 mL) and water (9.1 mL). The reaction mixture was stirred under reflux conditions for 5 hours. After completion of the reaction, it was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure, the pH was adjusted to 7-8 with base and subsequently extracted with dichloromethane (DCM). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the reddish brown solid product 5-amino-2-bromopyridine (1.58 g, 91.3% yield). | | References | [1] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 51 - 54
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Journal of Organic Chemistry, 2011, vol. 76, # 23, p. 9841 - 9844
[4] Patent: EP2886540, 2015, A1. Location in patent: Paragraph 0143; 0144
[5] Patent: US2014/93505, 2014, A1. Location in patent: Page/Page column |
| | 5-Amino-2-bromopyridine Preparation Products And Raw materials |
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