- Sodium-t-butoxide
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2026-09-10
- CAS:865-48-5
- Min. Order: 25KG
- Purity: 99%
- Supply Ability: 2000000 KG
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| | Sodium tert-butoxide Basic information | | Synthesis |
| | Sodium tert-butoxide Chemical Properties |
| Melting point | 180 °C | | Boiling point | 180°C/1mmHg | | density | 1,104 g/cm3 | | bulk density | 400kg/m3 | | vapor pressure | 0Pa at 20℃ | | refractive index | n20/D1.413 | | Fp | 12°C | | storage temp. | Store below +30°C. | | solubility | very slightly in Tetrahydrofuran | | form | Powder | | color | white to off-white | | Specific Gravity | 1.104 | | Water Solubility | reacts | | Sensitive | Air Sensitive & Hygroscopic | | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | | BRN | 3654215 | | InChI | 1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1 | | InChIKey | MFRIHAYPQRLWNB-UHFFFAOYSA-N | | SMILES | [Na+].CC(C)(C)[O-] | | CAS DataBase Reference | 865-48-5(CAS DataBase Reference) | | EPA Substance Registry System | 2-Propanol, 2-methyl-, sodium salt (865-48-5) |
| Hazard Codes | F,C,Xi | | Risk Statements | 11-14-34-37-35-36/37/38-40-19 | | Safety Statements | 26-36/37/39-43-45-7/8-8-16-36 | | RIDADR | UN 3206 4.2/PG 2 | | WGK Germany | 3 | | F | 1-3-10 | | TSCA | TSCA listed | | HazardClass | 4.2 | | PackingGroup | II | | HS Code | 29051900 | | Storage Class | 4.2 - Pyrophoric and self-heating hazardous materials | | Hazard Classifications | Eye Dam. 1
Flam. Sol. 1
Self-heat. 1
Skin Corr. 1B |
| | Sodium tert-butoxide Usage And Synthesis |
| Synthesis | Sodium tert-butoxide was synthesized using toluene or heptane as the solvent in the reaction system according to the following reaction formula: 
In a 500mL reactor equipped with a stirrer, reflux condenser, and thermometer, 240mL of toluene or heptane (moisture content less than 0.04%) was added, along with 9.8g of 99% sodium amide (approximately 0.25mol) and 19.0g of 99% tert-butanol (approximately 0.254mol). The molar ratio of sodium amide to tert-butanol was 1:1.015. The mixture was stirred thoroughly until completely dissolved. The temperature was raised to 70℃ to initiate the reaction. The released ammonia gas was absorbed by water or alkaline solution. The reaction was stopped after the temperature was raised to 100-110℃ and maintained for 1 hour. After the reaction was fully and completely completed, the reactants were cooled. Most of the reaction medium and a slight excess of tert-butanol were distilled off under normal pressure. The remaining small amount of reaction medium was then distilled off under reduced pressure, yielding approximately 25g of a white solid powder. The product purity, as determined by acid-base titration, was above 99%. | | Chemical Properties | white to light tan crystalline powder | | Uses | Sodium tert-butoxide is used as a strong base and a non-nucleophilic base. In organic synthesis, it serves as an intermediate in various reactions like condensation, rearrangement and ring-opening. Further, it finds use in agrochemicals, pharmaceuticals, colorants, aroma chemicals, detergents and biodiesel. It acts as a catalyst in polymerization and isomerization reactions. | | Flammability and Explosibility | Highly flammable | | Purification Methods | Its solubility in tert-BuOH is 0.208M at 30.2o and 0.382M at 60o, and it is quite soluble in tetrahydrofuran (32g/100g). It should not be used if it has a brown colour. [Feuer J Am Chem Soc 78 4364 1956, Hurd Inorg Synth I 87 1939, IR: Seubold J Org Chem 21 156 1956, Beilstein 1 IV 1609.] |
| | Sodium tert-butoxide Preparation Products And Raw materials |
| Preparation Products | tert-Butanol-->7-Methoxycoumarin-->6,6'-Dimethyl-2,2'-dipyridyl-->1-(4-Pyridyl)piperazine-->N,N'-Di-1-naphthyl-N,N'-diphenylbenzidine (NPB)-->3-Morpholinobenzaldehyde-->Flumazenil-->3-Morpholinophenol-->5,5'-Dimethyl-2,2'-dipyridyl-->4-Benzyloxy-2-chloropyrimidine-->methyl 3-(2-chloro-3，3，3-trifluoro-1-propenyl)-2，2-di-methyl-cyclopropane carboxylate-->2,4,5-Trifluorophenylacetic acid-->2-Methyl-2-propan(ol-d)-->1-Phenyl-1-cyclohexanecarbonitrile-->Tri-t-butoxysilanol-->1-(3-Pyridinyl)piperazine-->Carbonochloridic acid, 1,1-diMethylethyl ester |
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