2'-O-MOE-A(Bz)-3'-phosphoramidite manufacturers
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| | 2'-O-MOE-A(Bz)-3'-phosphoramidite Basic information |
| Product Name: | 2'-O-MOE-A(Bz)-3'-phosphoramidite | | Synonyms: | 2'-O-MOE-A(Bz)-3'-phosphoramidite;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)adenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite;2'-O-MOE-A(Bz)-CE Phosphoramidite;ADENOSINE, N-BENZOYL-5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-(2-METHOXYETHYL)-, 3'-[2-CYANOETHYL BIS(1-METHYLETHYL)PHOSPHORAMIDITE] (9CI);2'-O-MOE-Bz-A Phosphoramidite;5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-O-ME-A(BZ) PHOSPHORAMIDITE;DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite | | CAS: | 251647-53-7 | | MF: | C50H58N7O9P | | MW: | 932.01 | | EINECS: | | | Product Categories: | Amidite | | Mol File: | 251647-53-7.mol |  |
| | 2'-O-MOE-A(Bz)-3'-phosphoramidite Chemical Properties |
| storage temp. | -20°C | | form | Solid | | pka | 7.87±0.43(Predicted) | | color | White to off-white | | InChIKey | VPBYBQBHLYRLHG-VCCSSPGHNA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2'-O-MOE-A(Bz)-3'-phosphoramidite Usage And Synthesis |
| Description | 2'-O-MOE-A(Bz)-3'-phosphoramidite, also known as DMT-2'-O-MOE-rA(Bz) phosphoramidite, inserts 2'-O-methoxyethyl-modified adenosine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation. It is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). | | Chemical Properties | The IUPAC name of 2'-O-MOE-A(Bz)-3'-phosphoramidite is (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It is white to off-white powder. | | Uses | N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators. |
| | 2'-O-MOE-A(Bz)-3'-phosphoramidite Preparation Products And Raw materials |
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