Biotin-PEG4-Methyltetrazine manufacturers
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| | Biotin-PEG4-Methyltetrazine Basic information |
| Product Name: | Biotin-PEG4-Methyltetrazine | | Synonyms: | Biotin-PEG4-Methyltetrazine;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2-oxo-, (3aR,4R,6aS)-rel-;N-(2-(2-(2-(2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | | CAS: | 1835759-81-3 | | MF: | C27H39N7O6S | | MW: | 589.71 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-81-3.mol |  |
| | Biotin-PEG4-Methyltetrazine Chemical Properties |
| density | 1.233±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, sealed storage, away from moisture | | solubility | Soluble in DMSO, DMF | | pka | 13.90±0.40(Predicted) | | form | Solid | | color | Purple to purplish red |
| | Biotin-PEG4-Methyltetrazine Usage And Synthesis |
| Description | Biotin-PEG4-methyltetrazine is a click chemistry biotinylation reagent that can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. | | Uses | Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Biotin-PEG4-Methyltetrazine Preparation Products And Raw materials |
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