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Shanghai Chaolan Chemical Technology Center Gold
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021-QQ：65489617 15618227136 |
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Sales@ATKchemical.com |
| Products Intro: |
Product Name:CMLD-2
CAS:958843-91-9
Purity:98 Package:1G,5G,10G,50G,100G,500G
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:CMLD-2
CAS:958843-91-9
Purity:98% Remarks:Reach out to us for more information about custom solutions.
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CMLD-2 manufacturers
- CMLD-2
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- $98.00 / 1mg
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2025-11-10
- CAS:958843-91-9
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
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| Product Name: | CMLD-2 | | Synonyms: | 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-pyrrolidin-1-ylpropyl]-4-phenylchromen-2-one;5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one;5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one(WXC05487);2H-1-Benzopyran-2-one, 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-(1-pyrrolidinyl)propyl]-4-phenyl-;CMLD 2,CMLD2;CMLD-2, 10 mM in DMSO | | CAS: | 958843-91-9 | | MF: | C31H31NO6 | | MW: | 513.58094 | | EINECS: | | | Product Categories: | | | Mol File: | 958843-91-9.mol |  |
| | CMLD-2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (97.36 mM) | | form | Solid | | color | White to off-white | | InChIKey | PROGRNRRJJYCNX-UHFFFAOYSA-N | | SMILES | C1(=O)OC2=C(C(C3=CC=C(OC)C=C3)CC(=O)N3CCCC3)C(OC)=CC(OC)=C2C(C2=CC=CC=C2)=C1 |
| | CMLD-2 Usage And Synthesis |
| Description |
CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein, disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). It is a coumarin-derived small molecule. CMLD-2 induces apoptosis and exhibits antitumor activity in different cancer cells, such as colon, pancreatic, thyroid and lung cancer cell lines. These biological effects of CMLD-2 could be due to the reduced stability of HuR mRNA targets involved in proliferative and anti-apoptotic pathways. Hu antigen R (HuR) is an RNA-binding protein that can regulate target mRNA stability and translation[1].
| | Uses | CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2]. | | in vitro | CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein, disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). It is a coumarin-derived small molecule. CMLD-2 induces apoptosis and exhibits antitumor activity in different cancer cells, such as colon, pancreatic, thyroid and lung cancer cell lines. These biological effects of CMLD-2 could be due to the reduced stability of HuR mRNA targets involved in proliferative and anti-apoptotic pathways. Hu antigen R (HuR) is an RNA-binding protein that can regulate target mRNA stability and translation.
| | References | [1] Lorenzo Allegri. “The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells.” ACS Applied Electronic Materials (2019): 7374.
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| | CMLD-2 Preparation Products And Raw materials |
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