|
|
| | 3,5-Dimethyl-4-methoxy-2-pyridinemethanol Basic information |
| Product Name: | 3,5-Dimethyl-4-methoxy-2-pyridinemethanol | | Synonyms: | ((4-Methoxy-3,5-dimethyl)-2-pyridinyl)methanol;4-methoxy-3,5-dimethyl-2-pyridylmethanol;2-HYDROXYMETHYL-4-METHOXY-3,5-DIMETHYLPYRIDINE;3,5-DIMETHYL-2-HYDROXYMETHYL-4-METHOXYPYRIDINE;3,5-DIMETHYL-4-METHOXY-2-PYRIDINE METHANOL;4-METHOXY-3,5-DIMETHYL-2-HYDROXYMETHYL PYRIDINE;4-METHOXY-3,5-DIMETHYL-2-PYRIDINEMETHANOL;PYRMETHYLALCOHOL | | CAS: | 86604-78-6 | | MF: | C9H13NO2 | | MW: | 167.21 | | EINECS: | 289-258-5 | | Product Categories: | Heterocycle-Pyridine series;OLED materials,pharm chemical,electronic;Pharmaceutical intermediates;C9 to C46;Heterocyclic Building Blocks;Pyridines;Aromatic alcohols and diols;Pyridines derivates;bc0001 | | Mol File: | 86604-78-6.mol |  |
| | 3,5-Dimethyl-4-methoxy-2-pyridinemethanol Chemical Properties |
| Melting point | 56.5-60.5 °C(lit.) | | Boiling point | 115-135 °C(Press: 0.01 Torr) | | density | 1.092±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly) | | form | Solid | | pka | 13.27±0.10(Predicted) | | color | Off-White | | InChI | InChI=1S/C9H13NO2/c1-6-4-10-8(5-11)7(2)9(6)12-3/h4,11H,5H2,1-3H3 | | InChIKey | PSEPRWKZZJWRCB-UHFFFAOYSA-N | | SMILES | C1(CO)=NC=C(C)C(OC)=C1C | | CAS DataBase Reference | 86604-78-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3,5-Dimethyl-4-methoxy-2-pyridinemethanol Usage And Synthesis |
| Chemical Properties | White to light brown powder or crystal | | Uses | (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol can be used as wear-resistant rubber. | | General Description | 4-Methoxy-3,5-dimethyl-2-pyridinemethanol is a pyridine derivative. | | Synthesis | General procedure for the synthesis of 4-methoxy-3,5-dimethyl-2-hydroxymethylpyridine from 2-chloromethyl-3,5-dimethyl-4-methoxypyridine hydrochloride: 80 g of 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride was taken and 300 ml of methanol and 150 ml of water were added followed by 5.4 g of potassium iodide and 40.4 g of sodium hydroxide. The mixture was stirred and heated to reflux and the reaction lasted for 4 hours. Upon completion of the reaction, the methanol was removed by rotary evaporator. To the residue, 300 ml of drinking water was added, followed by extraction with dichloromethane (150 ml each time, 3 times). The organic phases were combined, washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated to give 50.0 g of a red oily liquid in 83.0% yield. | | References | [1] Patent: CN107382963, 2017, A. Location in patent: Paragraph 0013; 0017; 0021 |
| | 3,5-Dimethyl-4-methoxy-2-pyridinemethanol Preparation Products And Raw materials |
|