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| | 7-Azaindole-4-carboxylic acid Basic information |
| | 7-Azaindole-4-carboxylic acid Chemical Properties |
| Melting point | >330℃ | | density | 1.506±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Solid | | pka | 1.45±0.10(Predicted) | | color | White to cream | | InChI | 1S/C8H6N2O2/c11-8(12)6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)(H,11,12) | | InChIKey | HPPPHDPVSYYWCH-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccnc2[nH]ccc12 |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26-24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2 |
| | 7-Azaindole-4-carboxylic acid Usage And Synthesis |
| Chemical Properties | Yellow solid | | Uses | The sensitivity of 7-azaindole to its environment is demonstrated and then exploited by studying it and its analogs in peptides and in complexes with larger proteins containing many tryptophan residues. | | Synthesis | General procedure for the synthesis of 7-azaindole-4-carboxylic acid from 4-cyano-7-azaindole: A mixture of 4-cyano-7-azaindole (11.5 g, 80 mmol), sodium hydroxide (32 g, 800 mmol), water (100 mL) and ethanol (100 mL) was heated to reflux. After 6 hours of reaction, the reaction mixture was cooled to room temperature, neutralized and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration to afford 7-azaindole-4-carboxylic acid (10.4 g, 80% yield), which was used in subsequent reactions without further purification. | | References | [1] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 65
[2] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 52 |
| | 7-Azaindole-4-carboxylic acid Preparation Products And Raw materials |
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