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| | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Basic information |
| Product Name: | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE | | Synonyms: | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE;2-Benzofurancarboxylicacid,5-amino-,ethylester(9CI);Ethyl 5-aminobenzo[b]furan-2-carboxylate;Ethyl 5-amino-1-benzofuran-2-carboxylate (en);5-Amino-2-(ethoxycarbonyl)-1-benzofuran;5-Amino-2-(ethoxycarbonyl)-1-benzofuran, Ethyl 5-amino-1-benzofuran-2-carboxylate;ethyle5-aminobenzo[b]furan-2-carboxylate;5-Amino-2-(ethoxycarbonyl)-1-benzofura | | CAS: | 174775-48-5 | | MF: | C11H11NO3 | | MW: | 205.21 | | EINECS: | 1806241-263-5 | | Product Categories: | Esters;Furans, Benzofurans & Dihydrobenzofurans;AMINOACID | | Mol File: | 174775-48-5.mol |  |
| | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Chemical Properties |
| Melting point | 54-56°C | | Boiling point | 348.1±22.0 °C(Predicted) | | density | 1.258±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | soluble in Chloroform, DMSO | | form | Powder | | pka | 3.32±0.10(Predicted) | | color | Beige |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2932990090 |
| | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Usage And Synthesis |
| Chemical Properties | Brown Solid | | Uses | Ethyl 5-aminobenzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy. | | Uses | Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy. | | Synthesis | General procedure for the synthesis of ethyl 5-aminobenzofuran-2-carboxylate from ethyl 5-nitrobenzofuran-2-carboxylate: 20.0 g of ethyl 5-nitrobenzofuran-2-carboxylate was placed in a reaction flask and 300 mL of ethanol was added as a solvent. Subsequently, 2 g of 5% Pd/C catalyst was added. The reaction system was replaced twice with hydrogen to ensure that the reaction environment was a hydrogen atmosphere. The hydrogenation reaction was carried out for 3 hours by adjusting the hydrogen pressure to 0.3-0.5 MPa and controlling the reaction temperature in the range of 10-30°C. The reaction was carried out by filtration. Upon completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure and dried to give 17.1 g of ethyl 5-aminobenzofuran-2-carboxylate in 98% yield. | | References | [1] Patent: WO2013/153492, 2013, A2. Location in patent: Page/Page column 23
[2] Patent: US2015/87835, 2015, A1. Location in patent: Paragraph 0125
[3] ChemCatChem, 2014, vol. 6, # 11, p. 3153 - 3159
[4] Patent: CN107674052, 2018, A. Location in patent: Paragraph 0035-0037
[5] Patent: CN107540646, 2018, A. Location in patent: Paragraph 0041; 0042; 0043 |
| | ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Preparation Products And Raw materials |
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