|
|
| | 3-Bromo-4-methoxybenzaldehyde Basic information |
| | 3-Bromo-4-methoxybenzaldehyde Chemical Properties |
| Melting point | 51-54 °C (lit.) | | Boiling point | 108-110°C 1mm | | density | 1.5313 (rough estimate) | | refractive index | 1.5500 (estimate) | | Fp | 108-110°C/1mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform, DMSO, Ethyl Acetate | | form | Solid | | color | Off-White | | Sensitive | Air Sensitive | | BRN | 1636939 | | InChI | InChI=1S/C8H7BrO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3 | | InChIKey | QMPNFQLVIGPNEI-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(OC)C(Br)=C1 | | CAS DataBase Reference | 34841-06-0(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Bromo-4-methoxybenzaldehyde(34841-06-0) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-22 | | Safety Statements | 37/39-26 | | WGK Germany | 3 | | HazardClass | IRRITANT, AIR SENSITIVE | | HS Code | 29130000 | | Storage Class | 13 - Non Combustible Solids |
| | 3-Bromo-4-methoxybenzaldehyde Usage And Synthesis |
| Chemical Properties | WHITE TO BEIGE SOLID | | Uses | 3-Bromo-4-methoxybenzaldehyde may be used in the following studies:
- Asymmetric synthesis of a novel β-hydroxy-α-amino acid derivative, via Mukaiyama aldol reaction.
- Synthesis of 2-(3-bromo-4-methoxyphenyl)-5-fluorobenzothiazole.
- Preparation of 5-[(Z)-2-(3-bromo-4-methoxyphenyl)vinyl]-1,2-3-trimethoxybenzene.
- Total synthesis of engelhardione.
- Starting reagent for the synthesis of (2E)-3-(3-bromo-4-methoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one.
| | Synthesis Reference(s) | Tetrahedron, 41, p. 2903, 1985 DOI: 10.1016/S0040-4020(01)96614-1 | | General Description | 3-Bromo-4-methoxybenzaldehyde is formed by the solvent-free bromination of 4-methoxybenzaldehyde using 1,3-di-n-butylimidazolium tribromide, as a brominating reagent. | | Synthesis | (2) In a 4000 mL three-necked flask protected by passing nitrogen, 740.7 g of 3-bromo-4-hydroxybenzaldehyde, 2000 g of N,N-dimethylformamide and 558.0 g of potassium carbonate were added. The reaction system was cooled to 0~5 °C and 775 g of iodomethane was added dropwise slowly. After the dropwise addition, the reaction solution was concentrated and poured into ice water to precipitate a solid. After filtration and recrystallization, a white crystalline product 3-bromo-4-methoxybenzaldehyde was obtained as 752.7 g, yield 95.0%. | | References | [1] Patent: CN107118087, 2017, A. Location in patent: Paragraph 0015; 0031; 0035; 0039; 0043; 0047 |
| | 3-Bromo-4-methoxybenzaldehyde Preparation Products And Raw materials |
|