HO-PEG5-CH2COOtBu manufacturers
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| | HO-PEG5-CH2COOtBu Basic information |
| Product Name: | HO-PEG5-CH2COOtBu | | Synonyms: | HO-PEG5-CH2COOtBu;Hydroxy-PEG5-acetic acid;Hydroxy-PEG5-CH2COOH;HO-PEG5-CH2COOH/Acetic acid, 2-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-;Acetic acid, 2-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]-;17-hydroxy-3,6,9,12,15-pentaoxaheptadecanoic acid;HO-PEG5-CH2COOH | | CAS: | 52026-48-9 | | MF: | C12H24O8 | | MW: | 296.31 | | EINECS: | | | Product Categories: | | | Mol File: | 52026-48-9.mol |  |
| | HO-PEG5-CH2COOtBu Chemical Properties |
| Boiling point | 444.5±40.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | storage temp. | Store at 0-8 °C | | pka | 3.39±0.10(Predicted) |
| | HO-PEG5-CH2COOtBu Usage And Synthesis |
| Uses | HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HO-PEG5-CH2COOtBu Preparation Products And Raw materials |
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