trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride Suppliers list

Company Name:	Sichuan HongRi Pharma-Tech Co.,Ltd
Tel:	+8617390183901
Email:	cynthia@enlaibio.com
Products Intro:	Product Name:L-Hyp-Ome.HCl CAS:40216-83-9 Purity:98% Package:1kg;\|10kg;\|100kg

Company Name:	Capot Chemical Co.,Ltd.
Tel:	+86-（0）57185586718; +8613336195806
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Products Intro:	Product Name:Trans-4-Hydroxy-L-proline methyl ester hydrochloride CAS:40216-83-9 Purity:98% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

Company Name:	Shanghai Daken Advanced Materials Co.,Ltd
Tel:	+86-2158073036
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Products Intro:	Product Name:trans-4-Hydroxy-L-proline methyl ester hydrochloride CAS:40216-83-9 Purity:99% Package:1KG,5KG,10KG

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Tel:	+86-021-57951555 +8617317452075
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Products Intro:	CAS:40216-83-9

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	CAS:40216-83-9 Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G

trans-4-Hydroxy-L-proline methyl ester hydrochloride manufacturers

trans-4-Hydroxy-L-proline methyl ester hydrochloride Basic information

Product Name:	trans-4-Hydroxy-L-proline methyl ester hydrochloride
Synonyms:	H-HYP-OME HCL;H-L-HYP-OME HCL;HYDROXYPROLINE-OME HCL;(2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride;4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE
CAS:	40216-83-9
MF:	C6H12ClNO3
MW:	181.62
EINECS:	609-795-4
Product Categories:	Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives;Amino Acids & Derivatives;Chiral Reagents;Heterocycles;Hydroxyproline [Hyp];Nitrogen cyclic compounds;Amino Acid Derivatives;Amino Acids
Mol File:	40216-83-9.mol

trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties

Melting point	169 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
color	White to Off-White
BRN	4716932
Stability:	Hygroscopic
Major Application	peptide synthesis
InChI	InChI=1/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/s3
InChIKey	KLGSHNXEUZOKHH-SRJSDOSHNA-N
SMILES	[C@@H]1(NC[C@H](O)C1)C(=O)OC.Cl \|&1:0,3,r\|
CAS DataBase Reference	40216-83-9(CAS DataBase Reference)

Safety Information

MSDS Information

trans-4-Hydroxy-L-proline methyl ester hydrochloride Usage And Synthesis

Chemical Properties	White Solid
Uses	trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.
reaction suitability	reaction type: solution phase peptide synthesis
Synthesis	67-56-1 32968-78-8 40216-83-9 The general procedure for synthesizing trans-4-hydroxy-L-proline methyl ester hydrochloride from methanol and trans-4-hydroxy-L-proline hydrochloride is as follows: Example 1: (2S,4R)-4-hydroxy-2-pyrrolidine carboxylic acid hydrochloride (1.0 g, 7.6 mmol) was dissolved in methanol (25 mL) and cooled to 0°C. Thionyl chloride (0.83 mL, 11.4 mmol) was added slowly under stirring. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure to afford trans-4-hydroxy-L-proline methyl ester hydrochloride (1.2 g, 92% yield) in white solid form. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6).
IC 50	Non-cleavable Linker
References	[1] Organic Letters, 2018, vol. 20, # 1, p. 162 - 165 [2] Patent: WO2013/174937, 2013, A1. Location in patent: Page/Page column 74 [3] Patent: US2015/152048, 2015, A1. Location in patent: Paragraph 0447-0448

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Raw materials	Methanol-->Trans-4-Hydroxy-L-proline Hydrochloride-->Boc-Hyp-OH-->L-Hydroxyproline-->Acetyl chloride
Preparation Products	N-Boc-4-oxo-L-Proline methyl ester-->1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine-->N-BOC-cis-4-fluoro-L-proline-->(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride-->Glycine, L-prolyl-(4R)-4-hydroxy-L-prolyl-

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