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Alfa Aesar |
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400-6106006 |
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- 2-Methoxypropene
-
- $10.70
-
2026-05-28
- CAS:116-11-0
- Min. Order: 10kg
- Purity: 99%
- Supply Ability: 10000kg
- 2-Methoxypropene
-
- $10.00
-
2026-03-20
- CAS:116-11-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- 2-Methoxypropene
-
-
2025-04-04
- CAS:116-11-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
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| | 2-Methoxypropene Basic information |
| | 2-Methoxypropene Chemical Properties |
| Melting point | 25°C | | Boiling point | 34-36 °C (lit.) | | density | 0.753 g/mL at 25 °C (lit.) | | vapor pressure | 27.96 psi ( 55 °C) | | refractive index | n20/D 1.382(lit.) | | Fp | −21 °F | | storage temp. | 2-8°C | | solubility | Chloroform | | form | Liquid | | color | Clear colorless | | PH | 7 (H2O) | | Water Solubility | negligible | | Sensitive | Light Sensitive | | BRN | 1734635 | | InChI | 1S/C4H8O/c1-4(2)5-3/h1H2,2-3H3 | | InChIKey | YOWQWFMSQCOSBA-UHFFFAOYSA-N | | SMILES | COC(C)=C | | LogP | 1.7 at 21℃ and pH8.1-8.4 | | CAS DataBase Reference | 116-11-0(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Propene, 2-methoxy-(116-11-0) | | EPA Substance Registry System | 1-Propene, 2-methoxy- (116-11-0) |
| Hazard Codes | F+,Xn,F | | Risk Statements | 12-19-22-11 | | Safety Statements | 3-16-29-33-7/9-9-18 | | RIDADR | UN 1993 3/PG 1 | | WGK Germany | 1 | | RTECS | UD0800000 | | F | 8-10 | | Autoignition Temperature | 374 °F | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | I | | HS Code | 29091990 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Oral
Flam. Liq. 1 | | Hazardous Substances Data | 116-11-0(Hazardous Substances Data) | | Toxicity | rabbit,LD50,skin,> 20mL/kg (20mL/kg),American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. |
| | 2-Methoxypropene Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | 2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma. | | Preparation |
2-Methoxypropene is prepared in high yield from Succinic Anhydride, 2,2-Dimethoxypropane, benzoic acid, and Pyridine.
| | Reactivity Profile | 2-Methoxypropene is an electron-rich alkene used in the monoprotection of aliphatic, allylic, and propargylic alcohols, often followed by Claisen or other rearrangements; protection of peroxides, cyanohydrins, α-hydroxy ketones, and phenols; condensation with amines; protection of 1,2- and 1,3-diols, sometimes followed by Prins rearrangements; protection of 1,2-dithiols and α-hydroxy carbamates; participant in pericyclic reactions; formation of 2-methoxyallyl halides and substituted furans.
| | Toxics Screening Level | The initial threshold screening level (ITSL) for 2-Methoxy-1-propene is 6 μg/m3 based on an annual averaging time. | | Precautions | flammable liquid; light-sensitive; should be refrigerated.
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| | 2-Methoxypropene Preparation Products And Raw materials |
| Raw materials | Ethanone, 1-(3-methoxy-2,3-dimethyl-2-oxetanyl)- (9CI)-->Butanoic acid, 2,2,3,3,4,4,4-heptafluoro-, 1,1-dimethylethyl ester-->Butaneperoxoic acid, 2,2,3,3,4,4,4-heptafluoro-, 1,1-dimethylethyl ester-->2,3-Butanedione-->1,2-Diphenylethane-->Dimethyl carbonate-->Allene-->Pyridine-->2,2-Dimethoxypropane-->Methyl bromide-->Methyltriphenylphosphonium bromide | | Preparation Products | Teprenone Impurity 20-->Warfarin-->1,3-Dioxan-5-ol, 2,2-dimethyl--->1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol-->5-Ketohexanenitrile-->4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane |
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