3-Allyl-2-mercapto-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one synthesis
- Product Name:3-Allyl-2-mercapto-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
- CAS Number:42062-91-9
- Molecular formula:C13H14N2OS2
- Molecular Weight:278.39
57-06-7
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![2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid](/StructureFile/ChemBookStructure3/GIF/CB0274481.gif)
5936-58-3
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42062-91-9
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Yield:42062-91-9 85%
Reaction Conditions:
with acetic acid at 120; for 0.333333 h;Microwave irradiation;
Steps:
General procedure for synthesis of 3,5,6-trisubtituted-1H-2-thioxo thieno[2,3,-d] pyrimidin-4-ones(11)
General procedure: A mixture of 1b ( 1 mmol) and the appropriate isothiocyanate (1.1 mmol) in (10 ml)acetic acid, the mixture was irradiated in microwave oven at (300 W)120 °C for 20 min. The cold reaction was poured onto crushed ice, the solid obtained was filtered, washed with water, dried and recrystallized from ethanol. 3-Allyl-2-thioxo-2,3,5,6,7,8-hexahydro-1Hbenzo[4,5]thieno[2,3-d] pyrimidin-4-one(11a) M.p.: 234-237 °C, IR (cm-1) 3330, 1710,1210; 1H-NMR (DMSO-d6): 1.68-1.73, (m, 4H, 2CH2at C-6 d C-7), 2.30-2.50(m, 2H, CH2 at C-5), 2.89-2.90(m, 2H, CH2 at C-8); 4.35-4.50(br. m, 2H, NCH2),5.41-5.60 (m, 2H, =CH2); 5.89-6.30 (m, 1H, HC=),11.9(s, 1H, NH); MS: m/z (%); 278(100) (C13H14N2OS2 ); CHN: Anal. Calcd.: C, 56.11; H: 5.03;N: 10.07; Found: C: 56.60; H: 4.34; N: 9.85.
References:
Al-Issa [Oriental Journal of Chemistry,2014,vol. 30,# 2,p. 469 - 477]
![2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester](/CAS/GIF/108354-78-5.gif)
108354-78-5
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42062-91-9
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108-94-1
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42062-91-9
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108354-78-5
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$6.00/250mg
42062-91-9
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$18.90/250mg
![Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate](/CAS/GIF/4506-71-2.gif)
4506-71-2
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42062-91-9
20 suppliers
$18.90/250mg