N-Boc-Piperidine-4-carboxylic acid methyl ester synthesis
- Product Name:N-Boc-Piperidine-4-carboxylic acid methyl ester
- CAS Number:124443-68-1
- Molecular formula:C12H21NO4
- Molecular Weight:243.3
2971-79-1
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24424-99-5
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$13.50/25G
124443-68-1
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$6.00/5g
Yield:124443-68-1 98%
Reaction Conditions:
with triethylamine in dichloromethane at 25; for 12 h;Product distribution / selectivity;
Steps:
A.2.1
Synthesis of 9-(Azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane Trifluoroacetate (A4); Step-1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; To a stirred solution of methyl isonipecotate (127.2 mmol, 1 eq) in dichloromethane (200 ml) were added di-tert-butyldicarbonate (190.8 mmol, 1.5 eq) and triethylamine (254.4 mmol, 2.0 eq). The reaction mixture was stirred for 12 h at 25° C. It was then diluted with dichloromethane (100 ml) and washed with water (50 ml) and brine (50 ml). The organic layer was separated, dried over Na2SO4, concentrated and employed in the next step without further purification. Yield: 98%
References:
US2010/113417,2010,A1 Location in patent:Page/Page column 36
67-56-1
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84358-13-4
382 suppliers
$5.00/5g
124443-68-1
259 suppliers
$6.00/5g
67-56-1
781 suppliers
$9.00/25ml
498-94-2
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$5.00/10g
24424-99-5
865 suppliers
$13.50/25G
124443-68-1
259 suppliers
$6.00/5g
84358-13-4
382 suppliers
$5.00/5g
74-88-4
358 suppliers
$15.00/10g
124443-68-1
259 suppliers
$6.00/5g
84358-13-4
382 suppliers
$5.00/5g
18107-18-1
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$33.00/5g
124443-68-1
259 suppliers
$6.00/5g