| Identification | More | [Name]
Triethyl phosphite | [CAS]
122-52-1 | [Synonyms]
AURORA KA-1231
PHOSPHOROUS ACID TRIETHYL ESTER
TRIETHYL PHOSPHITE
TRIETHYL PHOSPHONATE
(C2H5O)3P
Ethyl phosphite, (EtO)3P
fosforyntrojetylowy
Phosphorus ether
Triethoxyphosphine
triethyl
Triethylphosphit
TriethyPhosphite
Triethylphosphite,98%
TRIETHYLPHOSPHATE ( MIN 98% ) GRADE B
TRIETHYLPHOSPHILE
triethyl phosphite94%
Phosphorous acid triethyl | [EINECS(EC#)]
204-552-5 | [Molecular Formula]
C6H15O3P | [MDL Number]
MFCD00009084 | [Molecular Weight]
166.16 | [MOL File]
122-52-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid. Insoluble in water; soluble in alcohol and
ether. Combustible. | [Melting point ]
-112°C | [Boiling point ]
65 °C | [density ]
0.969 g/mL at 25 °C(lit.) | [vapor pressure ]
<6 hPa (20 °C) | [refractive index ]
n20/D 1.413(lit.)
| [Fp ]
130 °F
| [storage temp. ]
Flammables area | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) | [form ]
liquid | [color ]
colorless | [Specific Gravity]
0.969 | [Odor]
characteristic, obnoxious, phosphiteodor | [explosive limit]
3.75-42.5%(V) | [Water Solubility ]
slightly soluble | [Hydrolytic Sensitivity]
7: reacts slowly with moisture/water | [Sensitive ]
Air & Moisture Sensitive | [BRN ]
956578 | [Dielectric constant]
10.9（65℃） | [Stability:]
Air Sensitive, Moisture Sensitive | [InChI]
1S/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3 | [InChIKey]
BDZBKCUKTQZUTL-UHFFFAOYSA-N | [SMILES]
P(OCC)(OCC)OCC | [Uses]
Synthesis, plasticizers, stabilizers, lubricant and
grease additives. | [CAS DataBase Reference]
122-52-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Phosphorous acid, triethyl ester(122-52-1) | [EPA Substance Registry System]
122-52-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Warning | [Hazard statements ]
H226-H302-H317-H412 | [Precautionary statements ]
P210-P233-P273-P280-P301+P312-P303+P361+P353 | [Hazard Codes ]
Xn | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/22:Harmful by inhalation and if swallowed . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2323 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
TH1130000
| [F ]
10-23 | [Autoignition Temperature]
250 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29209012 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 3
Flam. Liq. 3
Skin Sens. 1B | [Safety Profile]
Moderately toxic by
ingestion. A skin and eye irritant. Flammable
liquid when exposed to heat, sparks, or
flame. When heated to decomposition it
emits toxic fumes of POx. | [Hazardous Substances Data]
122-52-1(Hazardous Substances Data) | [Toxicity]
LD50 orl-rat: 1840 mg/kg JACTDZ 1,218,92 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ammonium chloride-->Xylene-->Phosphorus trichloride-->Diethyl phosphite-->Methyl Red | [Preparation Products]
4,4'-Vinylenedipyridine-->Cyclopentane-1,1-diacetic acid-->Spiro[4.5]decane-7,9-dione-->(2-Aminoethyl)phosphonic acid-->FONOFOS-->1-Cyclopentylidene-propan-2-one-->2-(2,3-Dihydro-1benzenesulfonyl-pyrrolo[2,3-b]pyridin-3-yl)ethanamine-->2-(2,3-Dihydro-1-benzenesulfonyl-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile-->4-Benzofurazancarboxaldehyde-->2-Methylcyclopropanecarboxylic acid-->Foscarnet sodium-->Thiophen-2-ylmethyl-phosphonic acid diethyl ester-->Geranic acid-->7-Methyl-1,6-octadiene-->Propylphosphonic anhydride-->4-Oxo-9,10-dihydro-4H-benzo(4,5)-cyclohepta-(1,2b)thiophene-->Diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate-->N-(2-Methylpropylidene)-butylamine-->2-(b-(2-Thienyl)vinyl)benzoicacid-->2-[2-(2-thienyl)ethyl]benzoic acid-->Diethyl(4-nitrobenzyl)phosphonate-->1-(2-Cyanostyryl)-4-(4-cyanostyryl)benzene-->Disodium 4,4'-bis(2-sulfostyryl)biphenyl |
| Hazard Information | Back Directory | [General Description]
A clear colorless liquid with a strong foul odor. Flash point 130°F. Less dense than water and insoluble in water. Vapors heavier than air. | [Reactivity Profile]
TRIETHYL PHOSPHITE(122-52-1) is colorless, moderately toxic liquid, combustible. Flammable when exposed to heat or flame. When heated to decomposition TRIETHYL PHOSPHITE(122-52-1) emits toxic fumes of oxides of phosphorus [Lewis, 3rd ed., 1993, p. 1271]. | [Air & Water Reactions]
Flammable. Insoluble in water. | [Health Hazard]
Exposure to high concentrations may cause headache, nausea, and dizziness due to reduced chlolinesterase activity. | [Fire Hazard]
Special Hazards of Combustion Products: May form hazardous decomposition products. | [Chemical Properties]
Triethyl phosphite is a clear colorless liquid with a strong foul odor. Insoluble in water; soluble in alcohol and ether. Combustible.Vapors heavier than air. | [Preparation]
Triethyl phosphite is produced in a closed system by reaction of phosphorous trichlorid and ethanol in the presence of an inorganic or organic base. The product is purified by distillation (Bayer AG, 2002a).
Triethyl phosphite is exclusively used as an intermediate for the manufacturing of different products: flame retardants (about 60 %), optical brighteners (about 15 %), pesticides (about 15 %), antioxidants (about 5 %), and pharmaceuticals (about 5 %). | [Reactions]
This reaction is currently used for the preparation of synthetically useful phosphonate reagents employed in modified retinal studies. Thus, diethyl 3-alkoxycarbonyl-2-propenylphosphonates are prepared in 72-91% yields by the reaction of methyl or ethyl 4-bromocrotonates with triethyl phosphite at 150-160°C. Similarly, diethyl 3-(ethoxycarbonyl)-2 methyl-2-propenylphosphonate is prepared in 81% yield from triethyl phosphite and ethyl 3-methyl-4-chlorocrotonate by heating at 180- 200°C.The diethyl (E)- and (Z)-3-ethoxycarbonyl-3 fluoro-2 -methyl-2-propenylphosphonates are respectively obtained from triethyl phosphite and (E)- or (Z)-4-bromo-2-fuoro-3-methyl-2-butenoates at 140°C. | [Flammability and Explosibility]
Flammable | [Toxicity evaluation]
The acute toxicity after oral, dermal, and inhalation exposure is relatively low. The oral LD50s in rats ranged between 1840 mg/kg bw (females) and 2470 mg/kg bw (males). Symptoms of rapid breathing and tremors were observed prior to death. In mice LD50 values above 3700 mg/kg bw were recorded. The 6-hour inhalation LC50 with an aerosol of 1.6-3.5 μm MMAD in rats was between 11,100 mg/m3 (females) and 11,600 mg/m3 (males). Clinical signs included eye and upper respiratory irritation, salivation and rapid, shallow breathing. The dermal LD50 in rabbits was between 2800 mg/kg bw (males) and > 3000 mg/kg bw (females). |
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