| Identification | Back Directory | [Name]
Aminooxy-PEG1-propargyl | [CAS]
1895922-69-6 | [Synonyms]
Aminooxy-PEG1-propargyl
Aminooxy-PEG1-propargyl HCl salt
O-(2-(Prop-2-yn-1-yloxy)ethyl)hydroxylamine
Hydroxylamine, O-[2-(2-propyn-1-yloxy)ethyl]- | [Molecular Formula]
C5H9NO2 | [MDL Number]
MFCD29764324 | [MOL File]
1895922-69-6.mol | [Molecular Weight]
115.13 |
| Chemical Properties | Back Directory | [Boiling point ]
212.1±20.0 °C(Predicted) | [density ]
1.035±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light, stored under nitrogen | [solubility ]
Soluble in Water, DMSO, DMF | [form ]
Liquid | [pka]
4.09±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG1-propargyl is a click chemistry PEG linker containing a propargyl group and an aminooxy group. The aminooxy group is reactive with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228 |
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