4-Amino-3-bromopyridine
- CAS No.
- 13534-98-0
- Chemical Name:
- 4-Amino-3-bromopyridine
- Synonyms
- 1H-PYRAZOLE-5-CARBOXYLIC ACID;AKOS PAO-0460;AKOS BBS-00005959;IFLAB-BB F3250-0675;3-Bromo-4-pyridinamine;3-Bromo-4-aminopyridine;4-AMINO-3-BROMOPYRIDINE;4-Pyridinamine, 3-bromo-;4--3- aMinopyridinebroMide;4-Amino-3-bromopyridine,98%
- CBNumber:
- CB0244790
- Molecular Formula:
- C5H5BrN2
- Molecular Weight:
- 173.01
- MDL Number:
- MFCD02068297
- MOL File:
- 13534-98-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 61-69 °C |
|---|---|
| Boiling point | 275.8±20.0 °C(Predicted) |
| Density | 1.6065 (rough estimate) |
| refractive index | 1.5182 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | pK1: 7.04(+1) (20°C) |
| form | Crystalline Powder |
| color | White to off-white |
| BRN | 110183 |
| InChI | InChI=1S/C5H5BrN2/c6-4-3-8-2-1-5(4)7/h1-3H,(H2,7,8) |
| InChIKey | DDQYSZWFFXOXER-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(N)=C1Br |
| CAS DataBase Reference | 13534-98-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-37/39-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT, AIR SENSITIVE | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-3-bromopyridine price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 685224 | 4-Amino-3-bromopyridine 97% | 13534-98-0 | 1g | $85.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 685224 | 4-Amino-3-bromopyridine 97% | 13534-98-0 | 5g | $405 | 2023-06-20 | Buy |
| Usbiological | 261243 | 4-Amino-3-bromopyridine Asreported | 13534-98-0 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 261243 | 4-Amino-3-bromopyridine Asreported | 13534-98-0 | 5g | $488 | 2026-06-03 | Buy |
| Usbiological | 261243 | 4-Amino-3-bromopyridine Asreported | 13534-98-0 | 10g | $659 | 2026-06-03 | Buy |
4-Amino-3-bromopyridine Chemical Properties, Uses, Production
Uses
4-Amino-3-bromopyridine is used as an intermediate in organic synthesis and pharmaceuticals.
Chemical Properties
yellow Cryst
Synthesis
504-24-5
13534-98-0
General procedure for the synthesis of 4-amino-3-bromopyridine from 4-aminopyridine: To a mixture of 4-aminopyridine (20.0 g, 0.21 mol) and acetonitrile (300.0 mL) was added N-bromosuccinimide (NBS) (39.8 g, 0.22 mol) in batches at 0 °C, the reaction was to be carried out protected from light. Subsequently, the reaction mixture was stirred at room temperature for 24 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by fast column chromatography (silica gel as stationary phase and dichloromethane/methanol=20:1 as eluent) to afford the target compound 4-amino-3-bromopyridine (33.2 g, 91.4% yield) as a light yellow solid. Mass spectrum (ESI) m/z: 172.9 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 37 - 50
[2] Organic and Biomolecular Chemistry, 2017, vol. 15, # 15, p. 3216 - 3231
[3] Patent: US2003/22883, 2003, A1
[4] Journal of the American Chemical Society, 2012, vol. 134, # 31, p. 12928 - 12931
4-Amino-3-bromopyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Panjin Greenchem Technology Co., Ltd. | 13121959385 | chemrocking@bjgreenchem.com | China | 223 | 58 |
| Jinan Huadian New Materials Co., Ltd | 18654517877 18654517877 | 372725134@qq.COM | China | 20 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 4-Amino-3-bromopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Bromo-4-pyridinamine
13534-98-0
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-25 | 4-Amino-3-bromopyridine
13534-98-0
|
$85.00-850.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-08-20 | 4-Amino-3-bromopyridine
13534-98-0
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- 3-Bromo-4-pyridinamine
13534-98-0
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-Amino-3-bromopyridine
13534-98-0
- $85.00-850.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 4-Amino-3-bromopyridine
13534-98-0
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
