OLOMOUCINE
- CAS No.
- 101622-51-9
- Chemical Name:
- OLOMOUCINE
- Synonyms
- OLOMOUCINE;NSC 666096;Olomoucine,highpurity;OLOMOUCINE SYNTHETIC >95%;Olomoucine, 10 mM in DMSO;Olomoucine,98%,high purity;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;Olomoucine - CAS 101622-51-9 - Calbiochem;Olomoucine, ATP-competitive CDK inhibitor;5-Bromo-21-fluorobenzylamine&hydrochloride
- CBNumber:
- CB0309080
- Molecular Formula:
- C15H18N6O
- Molecular Weight:
- 298.34
- MDL Number:
- MFCD00189360
- MOL File:
- 101622-51-9.mol
- MSDS File:
- SDS
| Melting point | 120-130 °C |
|---|---|
| Boiling point | 579.6±60.0 °C(Predicted) |
| Density | 1.36 |
| storage temp. | -20°C |
| solubility | DMSO, Methanol (Slightly) |
| form | Solid |
| pka | 14.55±0.10(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 101622-51-9(CAS DataBase Reference) |
| FDA UNII | 6A839B2HYS |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29339980 |
OLOMOUCINE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 495620 | Olomoucine | 101622-51-9 | 1mg | $71.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 495620 | Olomoucine | 101622-51-9 | 5mg | $272 | 2024-03-01 | Buy |
| Cayman Chemical | 10010240 | Olomoucine ≥98% | 101622-51-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10010240 | Olomoucine ≥98% | 101622-51-9 | 5mg | $70 | 2024-03-01 | Buy |
| Sigma-Aldrich | O0886 | Olomoucine ≥98% (HPLC) | 101622-51-9 | 1mg | $87.5 | 2024-03-01 | Buy |
OLOMOUCINE Chemical Properties,Uses,Production
Chemical Properties
white to off-white solid
Uses
A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.
Definition
ChEBI: Olomoucine is a 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a member of 2,6-diaminopurines and a member of ethanolamines.
Biological Activity
Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.
Biochem/physiol Actions
Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.
Enzyme inhibitor
This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase.
References
[1]. vesel j, havlicek l, strnad m, et al. inhibition of cyclin-dependent kinases by purine analogues. eur j biochem. 1994 sep 1;224(2):771-86.
[2]. abraham rt, acquarone m, andersen a, et al. cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. biol cell. 1995;83(2-3):105-20.
[3]. tian ds, xie mj, yu zy, et al. cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. brain res. 2007 mar 2;1135(1):177-85.
OLOMOUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
OLOMOUCINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 | info@chuchangbiotech.com | China | 202 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jk.info@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40228 | 62 |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17770 | 75 |
View Lastest Price from OLOMOUCINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | OLOMOUCINE
101622-51-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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- OLOMOUCINE
101622-51-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd