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OLOMOUCINE

OLOMOUCINE Structure
OLOMOUCINE structure
CAS No.
101622-51-9
Chemical Name:
OLOMOUCINE
Synonyms
OLOMOUCINE;NSC 666096;Olomoucine,highpurity;OLOMOUCINE SYNTHETIC >95%;Olomoucine, 10 mM in DMSO;Olomoucine,98%,high purity;N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE;Olomoucine - CAS 101622-51-9 - Calbiochem;Olomoucine, ATP-competitive CDK inhibitor;5-Bromo-21-fluorobenzylamine&hydrochloride
CBNumber:
CB0309080
Molecular Formula:
C15H18N6O
Molecular Weight:
298.34
MDL Number:
MFCD00189360
MOL File:
101622-51-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:36:39
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OLOMOUCINE Properties

Melting point 120-130 °C
Boiling point 579.6±60.0 °C(Predicted)
Density 1.36
storage temp. -20°C
solubility DMSO, Methanol (Slightly)
form Solid
pka 14.55±0.10(Predicted)
color White to off-white
InChI 1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
InChIKey GTVPOLSIJWJJNY-UHFFFAOYSA-N
SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
CAS DataBase Reference 101622-51-9(CAS DataBase Reference)
FDA UNII 6A839B2HYS
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  24/25
WGK Germany  3
HS Code  29339980
Storage Class 11 - Combustible Solids

OLOMOUCINE price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 495620 Olomoucine 101622-51-9 5mg $255 2026-04-30 Buy
Sigma-Aldrich 495620 Olomoucine 101622-51-9 1mg $62.1 2025-07-31 Buy
Cayman Chemical 10010240 Olomoucine ≥98% 101622-51-9 1mg $36 2026-04-30 Buy
Cayman Chemical 10010240 Olomoucine ≥98% 101622-51-9 5mg $77 2026-04-30 Buy
Cayman Chemical 10010240 Olomoucine ≥98% 101622-51-9 10mg $135 2026-04-30 Buy
Product number Packaging Price Buy
495620 5mg $255 Buy
495620 1mg $62.1 Buy
10010240 1mg $36 Buy
10010240 5mg $77 Buy
10010240 10mg $135 Buy

OLOMOUCINE Chemical Properties, Uses, Production

Chemical Properties

white to off-white solid

Uses

A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.

Definition

ChEBI: Olomoucine is a 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a member of 2,6-diaminopurines and a member of ethanolamines.

Biological Activity

Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M) and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.

Biochem/physiol Actions

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Enzyme inhibitor

This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase.

References

[1]. vesel j, havlicek l, strnad m, et al. inhibition of cyclin-dependent kinases by purine analogues. eur j biochem. 1994 sep 1;224(2):771-86.
[2]. abraham rt, acquarone m, andersen a, et al. cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. biol cell. 1995;83(2-3):105-20.
[3]. tian ds, xie mj, yu zy, et al. cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. brain res. 2007 mar 2;1135(1):177-85.

OLOMOUCINE Preparation Products And Raw materials

Raw materials

Preparation Products

OLOMOUCINE Suppliers

Global Suppliers ( 98)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chemsky（shanghai）International Co.,Ltd. 50
BOC Sciences 65
Thermo Fisher Scientific 75
Guangzhou Isun Pharmaceutical Co., Ltd 55
Bide Pharmatech Ltd. 60
Sigma-Aldrich 80
EMMX Biotechnology LLC 60

View Latest Price from OLOMOUCINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
OLOMOUCINE pictures 2021-08-12 OLOMOUCINE
101622-51-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • OLOMOUCINE pictures
  • OLOMOUCINE
    101622-51-9
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

OLOMOUCINE Spectrum

OLOMOUCINE(101622-51-9)1HNMR

101622-51-9 (OLOMOUCINE) Related Search:

OLOMOUCINE II SU 9516 NU6102 6-Benzylaminopurine Purvalanol a
Aminopurvalanol a 2(Bis-(hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine ARCYRIAFLAVIN A Roscovitine SELICICLIB
(S)-ROSCOVITINE 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine N9-Isopropyl-olomoucine OLOMOUCINE 6-Benzylamino-2-(2-dimethyl aminoethyl)amino-9-methylpurine
N-G-Propyl olomoucine OLOMOUCINE (DRY ICE) OLOMOUCINE II

1of4

6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE 2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine 2-(hydroxyethylamino)-6-benzylamino-9-methylpurine 2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL 2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE OLOMOUCINE OLOMOUCINE SYNTHETIC >95% Olomoucine,highpurity Olomoucine - CAS 101622-51-9 - Calbiochem 2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-methyl-9H-purine 2-[[9-Methyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol N-(2-Hydroxyethyl)-N'-benzyl-9-methyl-9H-purine-2,6-diamine Olomoucine,98%,high purity Olomoucine6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine NSC 666096 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- 5-Bromo-21-fluorobenzylamine&hydrochloride Olomoucine,Inhibitor,cyclindependent kinases,cdc2,purines,cell cycle,non-small cell lung cancer cell line,MR6.5,protein kinases,Cyclin dependent kinase,CDK,xenopus laevis oocytes,proliferation,inhibit,cdk2 Olomoucine, ATP-competitive CDK inhibitor Olomoucine, 10 mM in DMSO 101622-51-9 C15H18N6O Cell Signaling and Neuroscience Cell Cycle Regulators Cell Cycle Cell Biology Apoptosis and Cell Cycle BioChemical Heterocyclic Compounds Bases & Related Reagents Heterocycles Inhibitors inhibitor Nucleotides Protein Kinase