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OLOMOUCINE II

OLOMOUCINE II Structure
OLOMOUCINE II structure
CAS No.
500735-47-7
Chemical Name:
OLOMOUCINE II
Synonyms
Nsc736738;Olomoucine II, CDK/cyclin inhibitor;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
CBNumber:
CB4504061
Molecular Formula:
C19H26N6O2
Molecular Weight:
370.45
MDL Number:
MFCD06411574
MOL File:
500735-47-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:17
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OLOMOUCINE II Properties

Boiling point 618.5±65.0 °C(Predicted)
Density 1.32
storage temp. −20°C
solubility chloroform: 50 mg/mL, soluble
form powder
pka 9.83±0.30(Predicted)
color colorless
InChI 1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)
InChIKey NDUVSANREQEDRE-UHFFFAOYSA-N
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
Storage Class 11 - Combustible Solids

OLOMOUCINE II price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 495621 Olomoucine II 500735-47-7 5mg $308 2023-01-07 Buy
Cayman Chemical 33223 Olomoucine II ≥98% 500735-47-7 1mg $49 2026-04-30 Buy
ChemScene CS-0046074 Olomoucine II 500735-47-7 1mg $105 2026-06-04 Buy
aablocks AA00DJVG Olomoucine II ≥98% 500735-47-7 1mg $49 2026-05-28 Buy
American Custom Chemicals Corporation API0008354 OLOMOUCINE II 95.00% 500735-47-7 1MG $144.9 2021-12-16 Buy
Product number Packaging Price Buy
495621 5mg $308 Buy
33223 1mg $49 Buy
CS-0046074 1mg $105 Buy
AA00DJVG 1mg $49 Buy
API0008354 1MG $144.9 Buy

OLOMOUCINE II Chemical Properties, Uses, Production

Uses

Olomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 μM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1].

Definition

ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.

General Description

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

IC 50

CDK9/cycT: 0.06 μM (IC50); CDK2/cyclinE: 0.1 μM (IC50); CDK7/cyclin H: 0.45 μM (IC50); Cdk1/cyclin B: 7.6 μM (IC50); CDK4/cyclinD1: 19.8 μM (IC50)

References

[1] Krystof V, et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci. 2005 Aug;62(15):1763-71. DOI:10.1007/s00018-005-5185-1

OLOMOUCINE II Preparation Products And Raw materials

Raw materials

Preparation Products

OLOMOUCINE II Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9778 55
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
ChemeGen 18818260767 2625930290@qq.com China 6966 58
NewCan Biotech Limited +86-0571-86912261 +86-15658003402 sales@newcanbio.com China 1984 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
BOC Sciences 65
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
TargetMol Chemicals Inc. 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
ChemeGen 58
NewCan Biotech Limited 58
TargetMol Chemicals Inc. 58

View Latest Price from OLOMOUCINE II manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Olomoucine II pictures 2025-12-22 Olomoucine II
500735-47-7
 $159.00 99.94% 10g TargetMol Chemicals Inc.

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Olomoucine II - CAS 500735-47-7 - Calbiochem Nsc736738 Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine 2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]- Olomoucine II, CDK/cyclin inhibitor 500735-47-7