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(S)-ROSCOVITINE

(S)-ROSCOVITINE Structure
(S)-ROSCOVITINE structure
CAS No.
186692-45-5
Chemical Name:
(S)-ROSCOVITINE
Synonyms
Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem;(2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol;1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)-
CBNumber:
CB71498962
Molecular Formula:
C19H26N6O
Molecular Weight:
354.45
MDL Number:
MFCD02266402
MOL File:
186692-45-5.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:38
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(S)-ROSCOVITINE Properties

Melting point 103-106℃
Density 1.25
storage temp. -20C
form White solid
color White to off-white
FDA UNII 8C43G94891

(S)-ROSCOVITINE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth LHA69245 (S)-Roscovitine 186692-45-5 50mg $967.5 2026-06-04 Buy
Biosynth LHA69245 (S)-Roscovitine 186692-45-5 100mg $1346 2026-06-04 Buy
ChemScene CS-0045454 (S)-Roscovitine 99.15% 186692-45-5 5mg $87 2026-06-04 Buy
ChemScene CS-0045454 (S)-Roscovitine 99.15% 186692-45-5 10mg $141 2026-06-04 Buy
ChemScene CS-0045454 (S)-Roscovitine 99.15% 186692-45-5 25mg $282 2026-06-04 Buy
Product number Packaging Price Buy
LHA69245 50mg $967.5 Buy
LHA69245 100mg $1346 Buy
CS-0045454 5mg $87 Buy
CS-0045454 10mg $141 Buy
CS-0045454 25mg $282 Buy

(S)-ROSCOVITINE Chemical Properties, Uses, Production

Uses

(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].

in vivo

(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) shows neuroprotective efficacy in an adult mouse model of permanent MCAo (middle cerebral artery occlusion) [2].

Animal Model:20-25 g, P60 male C57 b/6 mice[2]
Dosage:25 mg/kg
Administration:I.p.; at 15 min before and 1 hr after pMCAo
Result:Decreased of the total infarct volume.

IC 50

CDK1: ≤1 μM (IC50); CDK2: ≤1 μM (IC50); CDK5: ≤1 μM (IC50); CDK7: ≤1 μM (IC50); CDK9: ≤1 μM (IC50)

storage

+4°C

References

[1] Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. DOI:10.3390/cells10010104
[2] Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117. DOI:10.1371/journal.pone.0012117

(S)-ROSCOVITINE Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-ROSCOVITINE Suppliers

Global Suppliers ( 10)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9788 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58

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SU 9516 NU6102 Roscovitine (S)-ROSCOVITINE

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(2S)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2S)- 186692-45-5 C19H26N6O