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4-(DIFLUOROMETHOXY)BENZALDEHYDE

4-(DIFLUOROMETHOXY)BENZALDEHYDE structure

CAS No.: 73960-07-3

Chemical Name:: 4-(DIFLUOROMETHOXY)BENZALDEHYDE

Synonyms: AKOS B006820;AKOS BBS-00000693;VITAS-BB TBB000651;TIMTEC-BB SBB003837;4-(DIFLUOROMETHOXY)BENZALDEHYDE;p-(difluoromethoxy)benzaldehyde;BENZALDEHYDE,4-(DIFLUOROMETHOXY);4-(Difluoromethoxy)benzaldehyde>4-(Difluoromethoxy)benzaldehyde98%;4-(Difluoromethoxy)benzaldehyde 98%

CBNumber:: CB0480530

Molecular Formula:: C8H6F2O2

Molecular Weight:: 172.13

MDL Number:: MFCD00042252

MOL File:: 73960-07-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:44:55

Product description	Number	Pack Size	Price
4-(Difluoromethoxy)benzaldehyde 95%	470112	5g	$53.8
4-(Difluoromethoxy)benzaldehyde >98.0%(GC)	D4334	1g	$28
4-(Difluoromethoxy)benzaldehyde >98.0%(GC)	D4334	5g	$110
4-(Difluoromethoxy)benzaldehyde ≥98%(GC)	45189	1G	$34.5
4-(Difluoromethoxy)benzaldehyde ≥98%(GC)	45189	5G	$130.8
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4-(DIFLUOROMETHOXY)BENZALDEHYDE Properties

Boiling point	222 °C (lit.)
Density	1.302 g/mL at 25 °C (lit.)
refractive index	n20/D 1.503(lit.)
Flash point	228 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Light yellow
λmax	256nm(EtOH)(lit.)
Sensitive	Air Sensitive
BRN	3049286
InChI	1S/C8H6F2O2/c9-8(10)12-7-3-1-6(5-11)2-4-7/h1-5,8H
InChIKey	ZWCXOJYJJINQGU-UHFFFAOYSA-N
SMILES	FC(F)Oc1ccc(C=O)cc1
CAS DataBase Reference	73960-07-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

PPE

Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-37/39-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29130000

Storage Class

10 - Combustible liquids

NFPA 704

	1
2		0

4-(DIFLUOROMETHOXY)BENZALDEHYDE price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	470112	4-(Difluoromethoxy)benzaldehyde 95%	73960-07-3	5g	$53.8	2026-04-30	Buy
TCI Chemical	D4334	4-(Difluoromethoxy)benzaldehyde >98.0%(GC)	73960-07-3	1g	$28	2026-04-30	Buy
TCI Chemical	D4334	4-(Difluoromethoxy)benzaldehyde >98.0%(GC)	73960-07-3	5g	$110	2026-04-30	Buy
Chem-Impex	45189	4-(Difluoromethoxy)benzaldehyde ≥98%(GC)	73960-07-3	1G	$34.5	2026-05-19	Buy
Chem-Impex	45189	4-(Difluoromethoxy)benzaldehyde ≥98%(GC)	73960-07-3	5G	$130.8	2026-05-19	Buy

Product number	Packaging	Price	Buy
470112	5g	$53.8	Buy
D4334	1g	$28	Buy
D4334	5g	$110	Buy
45189	1G	$34.5	Buy
45189	5G	$130.8	Buy

4-(DIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Uses,Production

Chemical Properties

light yellow liquid

Uses

4-(Difluoromethoxy)benzaldehyde may be used for the preparation of 4-(4-difluoro-methoxy-phen-yl)-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2,5-dione, via one-pot three-component reaction with cyclo-hexane-1,3-dione and urea.

General Description

4-(Difluoromethoxy)benzaldehyde is a p-difluoromethoxy substituted benzaldehyde.

Synthesis

75-45-6

123-08-0

73960-07-3

Example 1 Synthesis of 4-(difluoromethoxy)benzaldehyde: In a 1 L four-necked round-bottomed flask equipped with a thermometer, reflux condenser, mechanical stirrer, and gas introduction tube, 50 g (0.41 mol) of p-hydroxybenzaldehyde and 400 mL of isopropanol were added. After stirring the mixture for 20 minutes, 120 mL of a 120 mL aqueous solution containing 5 g of 18-crown-6 ether and 106.3 g (2.665 mol) of sodium hydroxide was slowly added dropwise. After the dropwise addition was completed, stirring was continued for 30 minutes and the mixture was subsequently heated to 65°C. Chlorodifluoromethane was slowly passed through the gas introduction tube over a period of 5-6 hours and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to 15 °C and 400 mL of water was added to quench the reaction. The reaction mixture was extracted three times with ether (3 x 300 mL). The organic layers were combined, washed with water to pH=7 and dried over anhydrous magnesium sulfate. The ether was removed by rotary evaporation and the residue was distilled under reduced pressure to collect the 85-87 °C/10 mmHg fraction to give 4-(difluoromethoxy)benzaldehyde in 95% yield.1H-NMR (ppm) δ: 9.87 (1H, s, -CHO); 7.70 (2H, m, 2,6-ArH); 7.36 (1H, t, J2H-F = 68 Hz, - CHF2); 6.96 (2H, m, 3,5-ArH).

References

[1] Patent: US2008/306027, 2008, A1. Location in patent: Page/Page column 7-8
[2] Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 8.1, p. 1317 - 1324
[3] Zhurnal Organicheskoi Khimii, 1992, vol. 28, # 8, p. 1652 - 1660
[4] Journal of Fluorine Chemistry, 1988, vol. 41, p. 247 - 262

4-(DIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Sodium chlorodifluoroacetate 4-Formylphenylboronic acid Difluorochloromethane Trifluoromethanesulfonic acid difluoromethyl ester Diethyl bromodifluoromethanephosphonate

4-Chlorobenzaldehyde 4-Hydroxybenzaldehyde Isopropyl alcohol Sodium hydroxide

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Preparation Products

4-(Difluoromethoxy)cinnamicacid

4-(DIFLUOROMETHOXY)BENZALDEHYDE Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Win-Win chemical CO., Limited	58

View Lastest Price from 4-(DIFLUOROMETHOXY)BENZALDEHYDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2021-08-12	4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-10	4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3	US $3.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
US $3.00 / KG
99%
Career Henan Chemical Co

4-(DIFLUOROMETHOXY)BENZALDEHYDE Spectrum

4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)¹HNMR 4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)IR

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