Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-(Difluoromethoxy)benzaldehyde

4-(Difluoromethoxy)benzaldehyde

4-(Difluoromethoxy)benzaldehyde Structure
4-(Difluoromethoxy)benzaldehyde structure
CAS No.
73960-07-3
Chemical Name:
4-(Difluoromethoxy)benzaldehyde
Synonyms
AKOS B006820;AKOS BBS-00000693;VITAS-BB TBB000651;TIMTEC-BB SBB003837;p-(difluoromethoxy)benzaldehyde;4-(Difluoromethoxy)benzaldehyde;BENZALDEHYDE,4-(DIFLUOROMETHOXY);4-(Difluoromethoxy)benzaldehyde>4-(Difluoromethoxy)benzaldehyde98%;4-(Difluoromethoxy)benzaldehyde 98%
CBNumber:
CB0480530
Molecular Formula:
C8H6F2O2
Molecular Weight:
172.13
MDL Number:
MFCD00042252
MOL File:
73960-07-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:21
Request For Quotation

4-(Difluoromethoxy)benzaldehyde Properties

Boiling point 222 °C (lit.)
Density 1.302 g/mL at 25 °C (lit.)
refractive index n20/D 1.503(lit.)
Flash point 228 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form clear liquid
color Colorless to Light yellow
λmax 256nm(EtOH)(lit.)
Sensitive Air Sensitive
BRN 3049286
InChI 1S/C8H6F2O2/c9-8(10)12-7-3-1-6(5-11)2-4-7/h1-5,8H
InChIKey ZWCXOJYJJINQGU-UHFFFAOYSA-N
SMILES FC(F)Oc1ccc(C=O)cc1
CAS DataBase Reference 73960-07-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-37/39-24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29130000
Storage Class 10 - Combustible liquids
NFPA 704
1
2 0

4-(Difluoromethoxy)benzaldehyde price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 470112 4-(Difluoromethoxy)benzaldehyde 95% 73960-07-3 5g $53.8 2026-04-30 Buy
TCI Chemical D4334 4-(Difluoromethoxy)benzaldehyde >98.0%(GC) 73960-07-3 1g $28 2026-04-30 Buy
TCI Chemical D4334 4-(Difluoromethoxy)benzaldehyde >98.0%(GC) 73960-07-3 5g $110 2026-04-30 Buy
Apolloscientific PC2847D 4-(Difluoromethoxy)benzaldehyde 98% 73960-07-3 5g $21 2026-06-04 Buy
Apolloscientific PC2847D 4-(Difluoromethoxy)benzaldehyde 98% 73960-07-3 25g $69 2026-06-04 Buy
Product number Packaging Price Buy
470112 5g $53.8 Buy
D4334 1g $28 Buy
D4334 5g $110 Buy
PC2847D 5g $21 Buy
PC2847D 25g $69 Buy

4-(Difluoromethoxy)benzaldehyde Chemical Properties, Uses, Production

Chemical Properties

light yellow liquid

Uses

4-(Difluoromethoxy)benzaldehyde may be used for the preparation of 4-(4-difluoro-methoxy-phen-yl)-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2,5-dione, via one-pot three-component reaction with cyclo-hexane-1,3-dione and urea.

General Description

4-(Difluoromethoxy)benzaldehyde is a p-difluoromethoxy substituted benzaldehyde.

Synthesis

Difluorochloromethane

75-45-6

4-Hydroxybenzaldehyde

123-08-0

4-(DIFLUOROMETHOXY)BENZALDEHYDE

73960-07-3

Example 1 Synthesis of 4-(difluoromethoxy)benzaldehyde: In a 1 L four-necked round-bottomed flask equipped with a thermometer, reflux condenser, mechanical stirrer, and gas introduction tube, 50 g (0.41 mol) of p-hydroxybenzaldehyde and 400 mL of isopropanol were added. After stirring the mixture for 20 minutes, 120 mL of a 120 mL aqueous solution containing 5 g of 18-crown-6 ether and 106.3 g (2.665 mol) of sodium hydroxide was slowly added dropwise. After the dropwise addition was completed, stirring was continued for 30 minutes and the mixture was subsequently heated to 65°C. Chlorodifluoromethane was slowly passed through the gas introduction tube over a period of 5-6 hours and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to 15 °C and 400 mL of water was added to quench the reaction. The reaction mixture was extracted three times with ether (3 x 300 mL). The organic layers were combined, washed with water to pH=7 and dried over anhydrous magnesium sulfate. The ether was removed by rotary evaporation and the residue was distilled under reduced pressure to collect the 85-87 °C/10 mmHg fraction to give 4-(difluoromethoxy)benzaldehyde in 95% yield.1H-NMR (ppm) δ: 9.87 (1H, s, -CHO); 7.70 (2H, m, 2,6-ArH); 7.36 (1H, t, J2H-F = 68 Hz, - CHF2); 6.96 (2H, m, 3,5-ArH).

References

[1] Patent: US2008/306027, 2008, A1. Location in patent: Page/Page column 7-8
[2] Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 8.1, p. 1317 - 1324
[3] Zhurnal Organicheskoi Khimii, 1992, vol. 28, # 8, p. 1652 - 1660
[4] Journal of Fluorine Chemistry, 1988, vol. 41, p. 247 - 262

4-(Difluoromethoxy)benzaldehyde Preparation Products And Raw materials

Raw materials

Sodium chlorodifluoroacetate 4-Formylphenylboronic acid Difluorochloromethane Trifluoromethanesulfonic acid difluoromethyl ester Diethyl bromodifluoromethanephosphonate
4-Chlorobenzaldehyde 4-Hydroxybenzaldehyde Isopropyl alcohol Sodium hydroxide

1of2

Preparation Products

4-(Difluoromethoxy)cinnamicacid

4-(Difluoromethoxy)benzaldehyde Suppliers

Global Suppliers ( 191)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Accela ChemBio Co.,Ltd. 64

View Latest Price from 4-(Difluoromethoxy)benzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(DIFLUOROMETHOXY)BENZALDEHYDE pictures 2026-03-20 4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
4-(DIFLUOROMETHOXY)BENZALDEHYDE pictures 2021-08-12 4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-(DIFLUOROMETHOXY)BENZALDEHYDE pictures 2019-07-10 4-(DIFLUOROMETHOXY)BENZALDEHYDE
73960-07-3
 $3.00 1KG 99% 100kg Career Henan Chemical Co

4-(Difluoromethoxy)benzaldehyde Spectrum

4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)1HNMR4-(DIFLUOROMETHOXY)BENZALDEHYDE(73960-07-3)IR

73960-07-3 (4-(Difluoromethoxy)benzaldehyde) Related Search:

4-(Trifluoromethoxy)benzoic acid hydrazide 4-(Trifluoromethoxy)phenacyl bromide 4-(Difluoromethoxy)acetophenone 2-(Difluoromethoxy)benzaldehyde 4-(Trifluoromethoxy)benzoyl chloride
4-(Trifluoromethoxy)benzamide 4-(Difluoromethoxy)benzaldehyde 3-(DIFLUOROMETHOXY)BENZALDEHYDE,3-(Difluoromethoxy)benzaldehyde 98%,3-(Difluoromethoxy)benzaldehyde98% 4-(Trifluoromethoxy)benzaldehyde 4'-(Trifluoromethoxy)acetophenone
4-(Trifluoromethoxy)benzoic acid 4-(Difluoromethoxy)phenacyl bromide (Difluoromethoxy)benzene Methyl 4-(trifluoromethoxy)benzoate 4-(Trifluoromethoxy)benzoyl acetonitrile
4-(Trifluoromethoxy)benzoyl fluoride 4-(1,1,2,2-Tetrafluoroethoxy)benzoic acid 3,4-Bis-difluoromethoxy-benzaldehyde

1of4

TIMTEC-BB SBB003837 VITAS-BB TBB000651 p-(difluoromethoxy)benzaldehyde BENZALDEHYDE,4-(DIFLUOROMETHOXY) 1-(Difluoromethoxy)-4-formylbenzene AKOS B006820 AKOS BBS-00000693 4-(Difluoromethoxy)benzaldehyde 98% 4-(Difluoromethoxy)benzaldehyde98% 4-(Difluoromethoxy)benzaldehyde> 4-(Difluoromethoxy)benzaldehyde, 97%, 4-(Difluoromethoxy)benzaldehyde 73960-07-3 Organic Building Blocks Building Blocks C8 Carbonyl Compounds Aldehydes Fluorine series Building Blocks Carbonyl Compounds Chemical Synthesis Difluoromethyl Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Benzaldehyde Aldehydes C8 Carbonyl Compounds