(1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate
- CAS No.
- 110928-44-4
- Chemical Name:
- (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate
- Synonyms
- methyl (1r,4r)-4-(hydroxymethyl)cyclohexane-1-carboxylate;trans-Methyl 4-(hydroxyMethyl)cyclohexanecarboxylate;trans-Methyl 4-(hydroxymethyl);TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOM;trans-4-(Methoxycarbonyl)cyclohexanemethanol;(1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate;Methyl trans-4-(hydroxymethyl)cyclohexane-1-carboxylate;4-Hydroxymethyl-cyclohexanecarboxylic acid methyl ester;trans-4-(Hydroxymethyl)cyclohexanecarboxylic acid methyl ester;(1R,4R)-4-(hydroxymethyl)cyclohexanecarboxylic acid methyl ester
- CBNumber:
- CB12489833
- Molecular Formula:
- C9H16O3
- Molecular Weight:
- 172.22
- MDL Number:
- MFCD03840884
- MOL File:
- 110928-44-4.mol
- MSDS File:
- SDS
| Boiling point | 251℃ |
|---|---|
| Density | 1.058 |
| Flash point | 57℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 15.05±0.10(Predicted) |
| form | Oil |
| color | Colourless |
| InChI | InChI=1S/C9H16O3/c1-12-9(11)8-4-2-7(6-10)3-5-8/h7-8,10H,2-6H2,1H3/t7-,8- |
| InChIKey | KOGYKIDJFOMAOF-ZKCHVHJHSA-N |
| SMILES | [C@@H]1(C(OC)=O)CC[C@@H](CO)CC1 |
| FDA UNII | R58V1A8V4H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HS Code | 2918199890 |
(1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM143110 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | 110928-44-4 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FM143110 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | 110928-44-4 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FM143110 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | 110928-44-4 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FM143110 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | 110928-44-4 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FM143110 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate | 110928-44-4 | 50g | $908.5 | 2026-06-04 | Buy |
(1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate Chemical Properties, Uses, Production
Uses
Methyl 4-(Hydroxymethyl)cyclohexanecarboxylate is a useful reagent in the synthesis and biopharmaceutical evaluation of imatinib analogs.
Synthesis
15177-67-0
110928-44-4
Tetrahydrofuran (100 mL) was cooled to -14 °C under argon protection and a tetrahydrofuran solution (100 mL) of 1.0 M borane-tetrahydrofuran complex was slowly added. Subsequently, a tetrahydrofuran solution (78 mL) of monomethyl trans-1,4-cyclohexanedicarboxylate (14.3 g) was added dropwise to this solution, and the dropwise acceleration was controlled so that the reaction was completed within 1 hour. The reaction mixture was warmed to 50 °C and stirring was continued at -10 °C for 1 hour. Upon completion of the reaction, water (160 mL) and saturated aqueous sodium bicarbonate solution (160 mL) were sequentially added to the reaction mixture under cooling in an ice bath, followed by extraction with ethyl acetate (160 mL x 4). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product obtained was purified by fast column chromatography on silica gel (eluent: chloroform/methanol=20:1) to give methyl trans-4-(hydroxymethyl)cyclohexanecarboxylate (13.25 g, yield: 100%) as an oil. Mass spectrum (APCI) m/z: 173 [M+H]+.
References
[1] Patent: EP1772454, 2007, A1. Location in patent: Page/Page column 55
[2] Patent: US2014/221350, 2014, A1. Location in patent: Paragraph 0166
[3] Patent: CN105566324, 2016, A. Location in patent: Paragraph 0394; 0395; 0396; 0397
[4] Patent: WO2013/192088, 2013, A1. Location in patent: Paragraph 00215
(1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijizhuang Zhoukun Pharmaceutical Technology Co., LTD | 0311-83784138 18633934202 | zhoukunpharma@163.com | China | 2420 | 58 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Beijin Yangguang Furui Chemical co.,Ltd. | 010-57495520 13521095525 | zhw512@foxmail.com | China | 487 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Yancheng Schiemann Biological Technology Co.,Ltd | 0515-88280676; 18921872653 | sales@ximanbio.com | China | 1524 | 56 |
View Latest Price from (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate
110928-44-4
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2021-04-08 | trans-(4-hydroxymethyl)cyclohexane-1-carboxylic acid methyl ester
110928-44-4
|
1g | 99% | 100kg/month | Pharmahands (Taizhou) Co., Ltd. | ||
 |
2020-09-23 | (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate
110928-44-4
|
1KG | 99.9% | 20tons | Hebei Runbin Biotechnology Co. LTD |
-
- trans-Methyl 4-(hydroxymethyl)cyclohexanecarboxylate
110928-44-4
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- trans-(4-hydroxymethyl)cyclohexane-1-carboxylic acid methyl ester
110928-44-4
- 99%
- Pharmahands (Taizhou) Co., Ltd.
-
- (1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate
110928-44-4
- $0.00
- 99.9%
- Hebei Runbin Biotechnology Co. LTD
110928-44-4 ((1r,4r)-methyl 4-(hydroxymethyl)cyclohexanecarboxylate) Related Search:
1of4
