SB 242084 (hydrochloride)
- CAS No.
- 1049747-87-6
- Chemical Name:
- SB 242084 (hydrochloride)
- Synonyms
- SB-242084 HCl salt;SB 242084 2HCL;CAS 1049747-87-6;SB 242084 (hydrochloride);SB242084;SB 242084;CAS 1049747-87-6;SB 242084 hydrochloride (SB-242084 hydrochloride);6-Chloro-5-methyl-N-[6-[(2-methyl-3-pyridyl)oxy]-3-pyridyl]indoline-1-carboxamide Dihydrochloride
- CBNumber:
- CB82592406
- Molecular Formula:
- C21H21Cl3N4O2
- Molecular Weight:
- 467.77604
- MDL Number:
- MOL File:
- 1049747-87-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| solubility |
Ethanol:1.0(Max Conc. mg/mL);2.14(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);21.38(Max Conc. mM) DMSO:59.63(Max Conc. mg/mL);127.47(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);64.13(Max Conc. mM) |
| form | A crystalline solid |
| color | Off-white to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
SB 242084 (hydrochloride) price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10096 | SB-242084 (hydrochloride) ≥98% | 1049747-87-6 | 1mg | $52 | 2026-04-30 | Buy |
| Cayman Chemical | 10096 | SB-242084 (hydrochloride) ≥98% | 1049747-87-6 | 5mg | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 10096 | SB-242084 (hydrochloride) ≥98% | 1049747-87-6 | 10mg | $201 | 2026-04-30 | Buy |
| Usbiological | 465901 | SB 242084 Hydrochloride | 1049747-87-6 | 1mg | $360 | 2026-06-03 | Buy |
| Usbiological | 465901 | SB 242084 Hydrochloride | 1049747-87-6 | 2.5mg | $545 | 2026-06-03 | Buy |
SB 242084 (hydrochloride) Chemical Properties, Uses, Production
Description
Serotonin (5-
Uses
SB 242084 Hydrochloride is an antagonist of the SR-2C.
Definition
ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator.
in vivo
SB 242084 dihydrochloride (0.1-1 mg/kg; i.p.; single; 20 min pre-test) improves the behavior of rats in social interaction tests[1].
SB 242084 dihydrochloride (5 mg/kg; i.p.; single; 20 min pre-test) improves mCPP-induced hypophagia in rats[1].
SB 242084 dihydrochloride (5, 10 mg/kg; i.p.; single) increases the levels of basal dialysate dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens of rats[3].
SB 242084 dihydrochloride (160-640 μg/kg; i.v.; single) dose-dependently and significantly increases the basal firing rate of VTA (ventral tegmental area) dopaminergic neurons, and the bursting activity is also enhanced in the same area, in vivo[3].
| Animal Model: | Male Sprague-Dawley (CD) rats[1]. |
| Dosage: | 0.1-1 mg/kg |
| Administration: | Intraperitoneal injection; single; 20 min pre-test |
| Result: | Significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliartest box. |
| Animal Model: | Male Sprague-Dawley (CD) rats(mCPP-induced hypophagia model)[1]. |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; single; 20 min pre-test |
| Result: | Significantly reduced the amount of food consumed by 23 h food-deprivedrats over a 1hr test period from the time of food presentation. |
| Animal Model: | Rats[2]. |
| Dosage: | 5, 10 mg/kg |
| Administration: | Intraperitoneal injection; single |
| Result: | Significantly increased basal dialysate dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens. |
IC 50
5-HT2C Receptor: 9.0 (pKi)
storage
Desiccate at +4°C
References
[1] G.A. KENNETT . SB 242084, a Selective and Brain Penetrant 5-HT2C Receptor Antagonist[J]. Neuropharmacology, 1997, 36 4: Pages 609-620. DOI: 10.1016/s0028-3908(97)00038-5
[2] STEVEN M. BROMIDGE. 6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist[J]. Journal of Medicinal Chemistry, 1997, 40 22: 3494-3496. DOI: 10.1021/jm970424c
[3] PAUL J FLETCHER Guy A H Judy Sinyard. The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists.[J]. Psychopharmacology, 2006, 187 4: 515-525. DOI: 10.1007/s00213-006-0453-9
[4] G L DALTON. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse.[J]. Psychopharmacology, 2006, 185 1: 45-57. DOI: 10.1007/s00213-005-0212-3
[5] JIANPING CHEN, JIA ZHOU* Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators[J]. Journal of Medicinal Chemistry, 2023, 66 14: 9992-10009. DOI: 10.1021/acs.jmedchem.3c00908
SB 242084 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
SB 242084 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
View Latest Price from SB 242084 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-22 | SB 242084 dihydrochloride
1049747-87-6
|
$73.00 | 10g | TargetMol Chemicals Inc. |
-
- SB 242084 dihydrochloride
1049747-87-6
- $73.00
- TargetMol Chemicals Inc.
1049747-87-6 (SB 242084 (hydrochloride)) Related Search:
1of4
