MMP-2/MMP-9 INHIBITOR IV
- CAS No.
- 292605-14-2
- Chemical Name:
- MMP-2/MMP-9 INHIBITOR IV
- Synonyms
- SB-3CT;CS-860;SB−SB-3CT (SB 3CT;SB-3CT, 10 mM in DMSO;MMP-2/MMP-9 INHIBITOR IV;MMP-2/MMP-9 INHIBITITOR IV;SB-3CT, MMP-2 and MMP-9 inhibitor;[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane;2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane
- CBNumber:
- CB9223336
- Molecular Formula:
- C15H14O3S2
- Molecular Weight:
- 306.4
- MDL Number:
- MFCD09836266
- MOL File:
- 292605-14-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-96°C |
|---|---|
| Boiling point | 501.4±46.0 °C(Predicted) |
| Density | 1.329±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to off-white |
| InChI | 1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2 |
| InChIKey | LSONWRHLFZYHIN-UHFFFAOYSA-N |
| SMILES | O=S(=O)(CC1CS1)c2ccc(Oc3ccccc3)cc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
MMP-2/MMP-9 INHIBITOR IV price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1326 | SB?3CT ≥98% (HPLC), powder | 292605-14-2 | 5mg | $390 | 2026-04-30 | Buy |
| Sigma-Aldrich | 444274 | MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem | 292605-14-2 | 500μg | $202 | 2026-04-30 | Buy |
| TCI Chemical | B5630 | SB-3CT | 292605-14-2 | 25MG | $209 | 2026-04-30 | Buy |
| TCI Chemical | B5630 | SB-3CT | 292605-14-2 | 100MG | $618 | 2026-04-30 | Buy |
| Cayman Chemical | 16337 | SB-3CT ≥95% | 292605-14-2 | 500μg | $41 | 2026-04-30 | Buy |
MMP-2/MMP-9 INHIBITOR IV Chemical Properties, Uses, Production
Uses
SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis.
Uses
SB3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.
Definition
ChEBI: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane is an aromatic ether.
Biochem/physiol Actions
SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).
in vivo
SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice[3].
| Animal Model: | Five-week-old male C.B.-17.SCID mice[3] |
| Dosage: | 50 mg/kg |
| Administration: | IP; every other day; five weeks |
| Result: | Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice. |
IC 50
MMP-2: 13.9 nM (Ki); MMP-9: 600 nM (Ki)
storage
Store at -20°C
MMP-2/MMP-9 INHIBITOR IV Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 |
View Latest Price from MMP-2/MMP-9 INHIBITOR IV manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | SB-3CT
292605-14-2
|
$41.00-162.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
![2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/185d93ab-5f96-40b1-998e-81889bf5adea.png) |
2020-01-02 | 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane
292605-14-2
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- SB-3CT
292605-14-2
- $41.00-162.00
- 98.00%
- TargetMol Chemicals Inc.
-
- 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane
292605-14-2
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
