2-Chloro-1,3-thiazole-4-carboxylic acid
- CAS No.
- 5198-87-8
- Chemical Name:
- 2-Chloro-1,3-thiazole-4-carboxylic acid
- Synonyms
- 4-Carboxy-2-chloro-1,3-thiazole;2-Chloro-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 2-chloro-;2-Chloro-1,3-thiazole-4-carboxylic acid;2-Chlorothiazole-4-Carboxylic Acid(WXC02298)
- CBNumber:
- CB61516890
- Molecular Formula:
- C4H2ClNO2S
- Molecular Weight:
- 163.58
- MDL Number:
- MFCD09870033
- MOL File:
- 5198-87-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 220 °C |
|---|---|
| Boiling point | 370.2±34.0 °C(Predicted) |
| Density | 1.693±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder |
| pka | 3.15±0.10(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C4H2ClNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8) |
| InChIKey | UVYJJJQMZPCYKY-UHFFFAOYSA-N |
| SMILES | S1C=C(C(O)=O)N=C1Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934100090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Chloro-1,3-thiazole-4-carboxylic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0389 | Ethyl 2-chlorothiazole-4-carboxylate Aldrich | 5198-87-8 | 1g | $77.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | JRD0388 | 2-Chlorothiazole-4-carboxylic acid Aldrich | 5198-87-8 | 1g | $114 | 2026-04-30 | Buy |
| TCI Chemical | C3349 | 2-Chlorothiazole-4-carboxylic Acid | 5198-87-8 | 1G | $104 | 2026-04-30 | Buy |
| Activate Scientific | AS50344 | 2-Chlorothiazole-4-carboxylic acid 97% | 5198-87-8 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS50344 | 2-Chlorothiazole-4-carboxylic acid 97% | 5198-87-8 | 5g | $69 | 2026-06-04 | Buy |
2-Chloro-1,3-thiazole-4-carboxylic acid Chemical Properties,Uses,Production
Synthesis
41731-52-6
5198-87-8
The general procedure for the synthesis of 2-chloro-1,3-thiazole-4-carboxylic acid from ethyl 2-chlorothiazole-4-carboxylate was as follows: 14.0 g (73.1 mmol) of ethyl 2-chlorothiazole-4-carboxylate was slowly added to 11.0 g (0.17 mol, 85% purity) of potassium hydroxide in a solution of ethanol/water (1:3, 200 mL), keeping the reaction temperature at 0 °C. The reaction mixture was stirred at room temperature for 16 hours before being diluted with water and washed twice with ether. Subsequently, the aqueous layer was acidified to pH=5.5 with concentrated hydrochloric acid and stirring was continued at room temperature for three days. The precipitate formed was collected by filtration and dried under vacuum at 40°C to give 7.0 g (56% yield, 95% purity) of 2-chloro-1,3-thiazole-4-carboxylic acid as a brown solid product.
References
[1] Patent: WO2011/3796, 2011, A1. Location in patent: Page/Page column 126; 127
[2] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[3] Patent: US5498630, 1996, A
[4] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 152
2-Chloro-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng Schiemann Biological Technology Co.,Ltd | 0515-88280676; 18921872653 | sales@ximanbio.com | China | 1524 | 56 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
View Lastest Price from 2-Chloro-1,3-thiazole-4-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
5198-87-8
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
5198-87-8
- $1.00
- 99%
- Career Henan Chemical Co
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