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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine structure

CAS No.: 42754-96-1

Chemical Name:: 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine

Synonyms: 4,6-dichloro-2H-pyrazolo[3,4-d]pyrimidine;SKL327;6-Dichloro-1H-pyrazolo[3;4,6-dichloropyrrolo[2,3-d]pyrimidine;4,6-Dichloropyrazolo[3,4-d]pyriMidine;4,6-Dichloro-1H-pyrazolo[3,4-C]pyrimidine;4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine;4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine;4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-

CBNumber:: CB21215944

Molecular Formula:: C5H2Cl2N4

Molecular Weight:: 189

MDL Number:: MFCD09835493

MOL File:: 42754-96-1.mol

MSDS File:: SDS

Last updated:2026-05-27 23:55:19

Request For Quotation

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Properties

Melting point	145 °C (decomp)
Boiling point	251.9±50.0 °C(Predicted)
Density	2.02±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.90±0.20(Predicted)
form	solid
color	Off-white to yellow
InChI	InChI=1S/C5H2Cl2N4/c6-3-2-1-8-11-4(2)10-5(7)9-3/h1H,(H,8,9,10,11)
InChIKey	CTYPROOLWJDUTA-UHFFFAOYSA-N
SMILES	C1(Cl)=NC(Cl)=C2C=NNC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	T
Risk Statements	25
Safety Statements	45-24/25
RIDADR	UN2811
HazardClass	IRRITANT
HS Code	29335990

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-D435865-5G	4,6-Dichloropyrazolo[3,4-d]pyrimidine	42754-96-1	5g	$167	2026-06-03	Buy
TRC	TRC-D435865-1G	4,6-Dichloropyrazolo[3,4-d]pyrimidine	42754-96-1	1g	$65	2026-06-03	Buy
AstaTech	60588	4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 97%	42754-96-1	1G	$28	2026-04-30	Buy
AstaTech	60588	4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 97%	42754-96-1	5G	$95	2026-04-30	Buy
AstaTech	60588	4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 97%	42754-96-1	10G	$150	2026-04-30	Buy

Product number	Packaging	Price	Buy
TRC-D435865-5G	5g	$167	Buy
TRC-D435865-1G	1g	$65	Buy
60588	1G	$28	Buy
60588	5G	$95	Buy
60588	10G	$150	Buy

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties, Uses, Production

Uses

4,6-Dichloro-1H-pyrazolo[3,4-C]pyrimidine is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Application

4,6-Dichloro-1H-pyrazolo[3,4-C]pyrimidine is an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.

Chemical Properties

Yellow solid

Synthesis

To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (19.0 g, 990 mmol) in methanol (300 mL) was added drop-wise a solution of hydrazine monohydrate (4.8 mL) in methanol (80 mL) at 0 °C followed by drop-wise addition of triethylamine (13 mL) in methanol (80 mL) at 0 °C. The mixture was stirred at the same temperature for 30 mm. The solvent was removed, and the residue was purified by flash chromatography to afford 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (10.3 g, 62 % yield) as a yellow solid. ‘H NMR (CDC13, 400IVIHz): 11.56 (br, 1H), 8.43 (s, 1H). MS m/z 190.68 [M+1].

References

[1] Patent: EP1772454, 2007, A1. Location in patent: Page/Page column 58
[2] Patent: WO2010/56320, 2010, A2. Location in patent: Page/Page column 60
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[4] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 119
[5] Patent: , 2016, . Location in patent: Paragraph 0019

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine synthesis

Synthesis of 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine from Oxipurinol

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Urea-13C Phosphorus oxitrichloride Urea 3-Amino-4-pyrazolecarbonitrile Acetic acid

Sodium hydroxide N,N-Diethylaniline Sulfuric acid 2,4,6-Trichloro-pyrimidine-5-carbaldehyde Oxipurinol

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Preparation Products

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Suppliers

Global Suppliers ( 226)

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Langyi Biomedical Technology Co., Ltd.	13706129682	tiffany@langyupharm.com	China	90	58
Shanghai Titan Enterprise Development Co., Ltd	16621224781	syy@titansci.com	China	2893	58
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Suzhou Chireach Biomedical Technology Co., Ltd.	0512-65856968	sales@chireach.com	China	59	70
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
Changzhou Langyi Biomedical Technology Co., Ltd.	58
Shanghai Titan Enterprise Development Co., Ltd	58
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Suzhou Chireach Biomedical Technology Co., Ltd.	70
Energy Chemical	61
Capot Chemical Co., Ltd	66
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59

View Latest Price from 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-05-15	4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine 42754-96-1	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 42754-96-1	$1.00	1kg	99%		Career Henan Chemical Co

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
42754-96-1
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
42754-96-1
$1.00
99%
Career Henan Chemical Co

4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Spectrum

4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(42754-96-1)¹HNMR

42754-96-1 (4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine) Related Search:

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4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4,6-dichloro-2H-pyrazolo[3,4-d]pyrimidine 1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro- 4,6-dichloropyrrolo[2,3-d]pyrimidine 4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine 4,6-Dichloropyrazolo[3,4-d]pyriMidine 6-Dichloro-1H-pyrazolo[3 4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(RS20012005) SKL327 4,6-Dichloro-1H-pyrazolo[3,4-C]pyrimidine 42754-96-1 C5H2N4Cl2 Aromatics Heterocycles Building Blocks Pyrazolo[x,x-y]pyridine Heterocycle-Pyrimidine series CHIRAL CHEMICALS