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2-Bromo-5-fluorobenzoic acid

2-Bromo-5-fluorobenzoic acid Structure
2-Bromo-5-fluorobenzoic acid structure
CAS No.
394-28-5
Chemical Name:
2-Bromo-5-fluorobenzoic acid
Synonyms
BUTTPARK 19\01-66;RARECHEM AL BO 0747;2-Bromo-5-fluorobenz;2-Bromo-5-Fluorobenzoic;2-BROMO-5-FLUOROBENZOIC ACID;2-bromo-5-fluorobenzoicacid,98%;Benzoic acid, 2-bromo-5-fluoro-;2-Bromo-5-fluorobenzoic Acid >2-Bromo-5-fluorobenzoic acid 98%;2-BroMo-5-fluorobenzoic Acid, 97+%
CBNumber:
CB7249219
Molecular Formula:
C7H4BrFO2
Molecular Weight:
219.01
MDL Number:
MFCD00142874
MOL File:
394-28-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:14:39
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2-Bromo-5-fluorobenzoic acid Properties

Melting point 154-157 °C (lit.)
Boiling point 291.1±25.0 °C(Predicted)
Density 1.789±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 2.51±0.10(Predicted)
color White to Almost white
BRN 2575978
InChI InChI=1S/C7H4BrFO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey OQBMJMJZMDBQSM-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC(F)=CC=C1Br
CAS DataBase Reference 394-28-5(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 2-bromo-5-fluoro- (394-28-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-24/25
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29163990
Storage Class 13 - Non Combustible Solids
NFPA 704
1
2 0

2-Bromo-5-fluorobenzoic acid price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B2722 2-Bromo-5-fluorobenzoic Acid >98.0%(GC)(T) 394-28-5 5g $94 2026-04-30 Buy
TCI Chemical B2722 2-Bromo-5-fluorobenzoic Acid >98.0%(GC)(T) 394-28-5 25g $308 2026-04-30 Buy
Usbiological 261967 2-Bromo-5-fluorobenzoic acid Asreported 394-28-5 25g $333 2026-06-03 Buy
Usbiological 261967 2-Bromo-5-fluorobenzoic acid Asreported 394-28-5 50g $438 2026-06-03 Buy
Usbiological 261967 2-Bromo-5-fluorobenzoic acid Asreported 394-28-5 100g $616 2026-06-03 Buy
Product number Packaging Price Buy
B2722 5g $94 Buy
B2722 25g $308 Buy
261967 25g $333 Buy
261967 50g $438 Buy
261967 100g $616 Buy

2-Bromo-5-fluorobenzoic acid Chemical Properties, Uses, Production

Uses

2-Bromo-5-fluorobenzoic acid, a common organic synthesis intermediate, is primarily used to synthesize target molecular structures by utilizing the bromine and fluorine atoms on the benzene ring. For example, the bromine atom can undergo Suzuki coupling to introduce an aromatic ring or alkyl chain; or it can be converted into boric acid or borate esters, leveraging the versatility of borate esters to synthesize complex molecules. The fluorine atom can also undergo a series of transformations, including aromatic nucleophilic substitution reactions. Finally, the carboxyl group on the benzene ring can be readily converted into amides, esters, viboramides, etc.

Chemical Properties

white to light yellow crystal powder

Synthesis

2-Bromo-5-fluorobenzoic acid is synthesized from 5-(2′-bromophenoxy)benzothiazole and 2,3,4,5,6-pentafluorobenzoyl chloride in three steps. The synthesis involves bromination of benzothiazole with NBS followed by reaction with 4-fluoroaniline to give the intermediate which is then reacted with pentafluorobenzoyl chloride.

References

[1] Patent: WO2005/56544, 2005, A1. Location in patent: Page/Page column 46

2-Bromo-5-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

2-Bromo-5-fluorobenzyl alcohol 2-Bromo-5-fluorobenzaldehyde 2-Amino-5-fluorobenzoic acid Sodium nitrite Hydrogen bromide
Cuprous bromide

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Preparation Products

N-Benzyl-2-bromo-5-fluorobenzamide

2-Bromo-5-fluorobenzoic acid Suppliers

Global Suppliers ( 388)
Supplier Tel Email Country ProdList Advantage
Nanjing XiLang Chemical Products Co., Ltd. 18936048580 chemxilang@163.com China 3909 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Nanjing XiLang Chemical Products Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 2-Bromo-5-fluorobenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-fluorobenzoic acid pictures 2026-09-18 2-Bromo-5-fluorobenzoic acid
394-28-5
 $120.00 1KG 98% 20 tons Speranza Chemical Co., Ltd.
2-Bromo-5-fluorobenzoic acid pictures 2026-02-02 2-Bromo-5-fluorobenzoic acid
394-28-5
 98% 200TONS Shaanxi Dideu Medichem Co. Ltd
2-Bromo-5-fluorobenzoic acid pictures 2024-04-15 2-Bromo-5-fluorobenzoic acid
394-28-5
 $1.00-100.00 100mg 0.99 5ton/month ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

2-Bromo-5-fluorobenzoic acid Spectrum

2-Bromo-5-fluorobenzoic acid(394-28-5)1HNMR2-Bromo-5-fluorobenzoic acid(394-28-5)19FNMR2-Bromo-5-fluorobenzoic acid(394-28-5)IR

394-28-5 (2-Bromo-5-fluorobenzoic acid) Related Search:

2-BROMO-4-FLUOROBENZOIC ACID 6-Bromo-2-Fluorobenzoic Acid,2-BROMO-6-FLUOROBENZOIC ACID,6-Bromo-2-Fluorobenzoic Acid 2-Fluoro-6-Bromobenzoic Acid METHYL 2-BROMO-4-FLUOROBENZOATE 2-nitro-4-Bromo-5-fluorobenzoic acid METHYL 2-BROMO-5-FLUOROBENZOATE
2-Bromo-3,4,5,6-tetrafluorobenzoic acid 3-Bromo-5-fluorobenzoic acid 4-Bromo-2-fluorobenzoic acid 4-Bromo-3-fluorobenzoic acid 5-Bromo-2-fluorobenzoic acid
3-Bromo-2-fluorobenzoic acid 2-Bromo-3-fluorobenzoic acid 3-Bromo-4-fluorobenzoic acid 3-Bromo-4-fluoro-benzoic acid methyl ester 2-Amino-3,5-dibromo-6-fluorobenzoic acid
2-Bromo-4,5-difluorobenzoic acid Methyl 4-bromo-3-fluorobenzoate 98 Methyl 3-bromo-5-fluorobenzoate

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2-Bromine-5-Fluoride Benzoic Acids 2-Bromo-5-fluorobenz 2-bromo-5-fluorobenzoicacid,98% RARECHEM AL BO 0747 2-BroMo-5-fluorobenzoic Acid, 97+% BUTTPARK 19\01-66 2-BROMO-5-FLUOROBENZOIC ACID 2-Bromo-5-Fluorobenzoic 2-Bromo-5-fluorobenzoic acid 98% 2-Bromo-5-fluorobenzoic Acid > Benzoic acid, 2-bromo-5-fluoro- 2-Bromo-5-flu2-Bromo-5-fluorobenzoic acidorobenzoic acid 394-28-5 2-Bromo-5-fluorobenzoic acid 2-bromo-5-fluorobenzoic acid, 99%min 2-Bromo-5-fluorobenzoic acid (ACI) 394-28-5 C6H3BrFCOOH C7 Carbonyl Compounds Carboxylic Acids Building Blocks Organic Building Blocks Benzoic acid series C7 Carbonyl Compounds Carboxylic Acids Bromine Compounds Fluorine Compounds intermediate Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Miscellaneous Acids & Esters FINE Chemical & INTERMEDIATES blocks Bromides Carboxes FluoroCompounds Acids and Derivatives Halides Fluorin-contained Benzoic acid series john's