Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-N-Boc-aminocyclohexanone

4-N-Boc-aminocyclohexanone

4-N-Boc-aminocyclohexanone Structure
4-N-Boc-aminocyclohexanone structure
CAS No.
179321-49-4
Chemical Name:
4-N-Boc-aminocyclohexanone
Synonyms
N-4-BOC-AMINOCYCLOHEXANONE;TERT-BUTYL 4-OXOCYCLOHEXYLCARBAMATE;(4-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;BOC-4-AMINOCYCLOHEXANONE;4-(Boc-Amino)cyclohexanone;4-N-BOC-AMINOCYCLOHEXANONE;N-Boc-4-Aminocyclohexanone;4-N-Boc-Aminocyclohexanone4;4-N-BOC-4-AMINOCYCLOHEXANONE;N-T-BOC-4-AMINOCYCLOHEXANONE
CBNumber:
CB2149316
Molecular Formula:
C11H19NO3
Molecular Weight:
213.27
MDL Number:
MFCD00798168
MOL File:
179321-49-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:00:49
Request For Quotation

4-N-Boc-aminocyclohexanone Properties

Melting point 114-118℃
Boiling point 335.9±31.0 °C(Predicted)
Density 1.06±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility soluble in Methanol
form powder to crystal
pka 12.19±0.20(Predicted)
color White to Almost white
InChI InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8H,4-7H2,1-3H3,(H,12,14)
InChIKey WYVFPGFWUKBXPZ-UHFFFAOYSA-N
SMILES C(OC(C)(C)C)(=O)NC1CCC(=O)CC1
CAS DataBase Reference 179321-49-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  Xi,N
Risk Statements  36/37/38-50
Safety Statements  26-36/37/39-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Hazard Note  Irritant
HS Code  29242990
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Acute 1

4-N-Boc-aminocyclohexanone price More Price(101)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 750816 N-4-Boc-aminocyclohexanone 95% 179321-49-4 5g $72 2026-04-30 Buy
TCI Chemical B3856 4-(tert-Butoxycarbonylamino)cyclohexanone >98.0%(GC) 179321-49-4 1g $17 2026-04-30 Buy
TCI Chemical B3856 4-(tert-Butoxycarbonylamino)cyclohexanone >98.0%(GC) 179321-49-4 5g $54 2026-04-30 Buy
Usbiological 429642 4-(N-Boc-amino)cyclohexanone 179321-49-4 1g $319 2026-06-03 Buy
Usbiological 429642 4-(N-Boc-amino)cyclohexanone 179321-49-4 5g $403 2026-06-03 Buy
Product number Packaging Price Buy
750816 5g $72 Buy
B3856 1g $17 Buy
B3856 5g $54 Buy
429642 1g $319 Buy
429642 5g $403 Buy

4-N-Boc-aminocyclohexanone Chemical Properties, Uses, Production

Uses

4-N-Boc-aminocyclohexanone is a chemical that inhibits the proliferation of cancer cells in vitro. It also has an antiproliferative effect on fibroblast cells, which may be due to its ability to inhibit protein synthesis and induce cell death by apoptosis.It can also be used for the preparation of photoresponsive polymers that are used in drug delivery systems. 

Synthesis

4-N-BOC-AMINO-CYCLOHEXANOL

224309-64-2

4-N-Boc-aminocyclohexanone

179321-49-4

The general procedure for the synthesis of 4-N-Boc-aminocyclohexanone from 4-(Boc-amino)cyclohexanol was as follows: a dichloromethane solution of dimethyl sulfoxide (6 mL, containing 2.0 mL of dimethyl sulfoxide, 28.2 mmol) was added dropwise to a dichloromethane solution (30 mL) of oxalyl chloride (1.7 mL, 19.5 mmol) over a 10-minute period at -60°C. The dichloromethane solution was stirred for 10 minutes. After dropwise addition, stirring was continued at -60 °C for 10 min. Subsequently, tert-butyl 4-hydroxycyclohexylcarbamate (2.56 g, 11.9 mmol) was added dropwise to a dichloromethane solution (140 mL) over a period of 35 min and the reaction mixture was stirred at -60 °C for 40 min. Next, triethylamine (8.4 mL, 60.3 mmol) was added at -60 °C, after which the reaction mixture was allowed to warm up naturally to room temperature. After completion of the reaction, water was added to the mixture and extracted with chloroform. The organic layer was washed sequentially with saturated aqueous ammonium chloride solution and saturated aqueous sodium chloride solution, and then dried with magnesium sulfate. The solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: chloroform/ethyl acetate) to give tert-butyl 4-oxocyclohexylcarbamate (2.23 g, 87% yield).1H-NMR (DMSO-d6) data were as follows: 1.06-1.20 (4H, m), 1.35 (9H, s), 1.69-1.76 (4H, m). 3.12-3.31 (2H, m), 4.48 (1H, s), 6.64 (1H, d, J = 7.5 Hz).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 71
[2] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2633 - 2644
[3] Patent: WO2015/22664, 2015, A1. Location in patent: Paragraph 00219;00220
[4] Patent: TW2017/36341, 2017, A. Location in patent: Paragraph 0489-0491
[5] Patent: WO2005/21515, 2005, A2. Location in patent: Page/Page column 72-73

4-N-Boc-aminocyclohexanone Preparation Products And Raw materials

Raw materials

4-N-Boc-amino-cyclohexanol Boc-trans-4-aminocyclohexanol Dimethyl sulfoxide Dichloromethane Oxalyl chloride
Triethylamine

1of2

Preparation Products

4,4-Difluorocyclohexylamine hydrochloride (2-AMino-5,6,7,8-tetrahydro-quinazolin-6-yl)-carbaMic acid tert-butyl ester 4-(4-tert-ButoxycarbonylaMino-cyclohexyl)-piperazine-1-carboxylic acid benzyl ester 4-Amino-1-methylcyclohexanol hydrochloride Trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-cyclohex-1-enyl ester
2-BroMo-4,5,6,7-tetrahydrobenzo[d]thiazol-6-aMine

1of2

4-N-Boc-aminocyclohexanone Suppliers

Global Suppliers ( 331)
Supplier Tel Email Country ProdList Advantage
Anhui Leyong Biotechnology Co.,Ltd 15055708011 2093564781@qq.com China 400 58
Bengbu Nako Chemical Co., Ltd. 0552-3068102 13966060073 sales@nakochem.com China 26 58
Hefei TianRui Pharmaceutical Chemistry Co., Ltd. 0551-68933033 13956024211 trchem@163.com China 99 58
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9848 55
Anhui Beirui Pharmaceutical Technology Co., Ltd 0551-68665055 18130089676 ahbrchem@163.com China 18 58
Hefei Yule Pharmaceutical Technology Co., Ltd 18756548891 15955174703 149498276@qq.com China 77 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Anhui Leyong Biotechnology Co.,Ltd 58
Bengbu Nako Chemical Co., Ltd. 58
Hefei TianRui Pharmaceutical Chemistry Co., Ltd. 58
Chengdu Firster Pharmaceutical Co., Ltd. 60
Amatek Scientific Co. Ltd. 55
Anhui Beirui Pharmaceutical Technology Co., Ltd 58
Hefei Yule Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81

View Latest Price from 4-N-Boc-aminocyclohexanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-N-Boc-aminocyclohexanone pictures 2026-08-20 4-N-Boc-aminocyclohexanone
179321-49-4
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
4-N-Boc-aminocyclohexanone pictures 2026-06-30 4-N-Boc-aminocyclohexanone
179321-49-4
 1kg 98% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-N-Boc-aminocyclohexanone pictures 2026-03-20 4-N-Boc-aminocyclohexanone
179321-49-4
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

4-N-Boc-aminocyclohexanone Spectrum

4-N-Boc-aminocyclohexanone(179321-49-4)1HNMR

179321-49-4 (4-N-Boc-aminocyclohexanone) Related Search:

Tris(trimethylsilyl)phosphate tert-Butyl peroxybenzoate Urethane tert-Butyl carbazate tert-Butyl peroxyacetate
Methyl anthranilate Cyclohexanone tert-Butyl carbamate Cyhalofop-butyl Molasses
Methyl acrylate 4-Aminobenzoic acid tert-Butyl 4-aminobenzoate Buprofezin Diethylene glycol monobutyl ether
tert-Butanol Polyurethane Butyl oleate

1of4

BOC-4-AMINOCYCLOHEXANONE 4-N-BOC-AMINOCYCLOHEXANONE 4-N-BOC-4-AMINOCYCLOHEXANONE 4-AMINOCYCLOHEXANONE N-BOC PROTECTED N-T-BOC-4-AMINOCYCLOHEXANONE tert-Butyl (4-oxocyclohex-1-yl)carbamate, 1-[(tert-Butoxycarbonyl)amino]-4-oxocyclohexane CarbaMic acid,N-(4-oxocyclohexyl)-, 1,1-diMethylethyl ester N-4-Boc-aminocyclohexanone 95% 4-(Boc-Amino)cyclohexanone Carbamic acid, (4-oxocyclohexyl)-, 1,1-dimethylethyl ester (9CI) 2-aMino-4-(3-chloro phenyl) thiazole 4-N-Boc-aMinocyclohexanone/tert-butyl 4-oxocyclohexylcarbaMate 4-AMinocyclohexanone N-tertbutyl ester tert-butyl 4-oxocyclohexylcarbam 4-Aminocyclohexan-1-one, N-BOC protected tert-Butyl (4-oxocyclohex-1-yl)carbamate, 1-Oxo-4-[(tert-butoxycarbonyl)amino]cyclohexane tert-Butyl N-(4-oxocyclohexyl)carbaMate 4-(TERT-BUTOXYCARBONYLAMINO) CYCLOHEXANONE 4-N-Boc-Aminocyclohexanone4 N-Boc-4-Aminocyclohexanone 4-(tert-butyloxycarbonylamino)cyclohexanone 4-Aminocyclohexan-1-one, N-BOC protected 98% 4-(tert-Butoxycarbonylamino)cyclohexanone > ert-butylN-(4-oxocyclohexyl)carbamate 4-N-Boc-aminocyclohexanone ISO 9001：2015 REACH 7-Piperazinecarboxamide,N,N-dimethyl- N-4-Boc-aminocyclohexanone,98% N-4-Boc-aminocyclohexanone (4-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER N-4-BOC-AMINOCYCLOHEXANONE TERT-BUTYL 4-OXOCYCLOHEXYLCARBAMATE 179321-49-4 885280-38-7 C11H19NO3 Acids and Derivatives Carbonyl Compounds pharmacetical CHIRAL CHEMICALS Building Blocks C10 to C11 C11 to C12 Chemical Synthesis Ethers New Products for Chemical Synthesis Nitrogen Compounds Organic Building Blocks Oxygen Compounds N-BOC Amines blocks