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BOC-D-4-Fluorophe

BOC-D-4-Fluorophe structure

CAS No.: 57292-45-2

Chemical Name:: BOC-D-4-Fluorophe

Synonyms: N-(tert-Butoxycarbonyl)-4-fluoro-D-phenylalanine;(R)-2-((tert-Butoxycarbonyl)aMino)-3-(4-fluorophenyl)propanoic acid;Boc-D-4-F-Phe;BOC-D-4-FLUOROPHE;BOC-D-PHE(4-F)-OH;BOC-D-PHE(P-F)-OH;BOC-4-FLUORO-D-PHE;RARECHEM BK PT 0035;BOC-P-FLUORO-D-PHE-OH;BOC-4-FLUORO-D-PHE-OH

CBNumber:: CB2389932

Molecular Formula:: C14H18FNO4

Molecular Weight:: 283.3

MDL Number:: MFCD00079669

MOL File:: 57292-45-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:28:54

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BOC-D-4-Fluorophe Properties

Melting point	83-86 °C
alpha	-8 º (c=1,MeOH)
Boiling point	431.2±40.0 °C(Predicted)
Density	1.1918 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder to crystal
pka	3.87±0.10(Predicted)
color	White to Almost white
CAS DataBase Reference	57292-45-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H227
Precautionary statements	P501-P261-P270-P210-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312-P403+P235
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	37/39-26-24/25
WGK Germany	3
Hazard Note	Irritant/Keep Cold
HS Code	29242990

BOC-D-4-Fluorophe price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3303	N-(tert-Butoxycarbonyl)-4-fluoro-D-phenylalanine >98.0%(T)	57292-45-2	1g	$42	2023-06-20	Buy
TCI Chemical	B3303	N-(tert-Butoxycarbonyl)-4-fluoro-D-phenylalanine >98.0%(T)	57292-45-2	5g	$166	2023-06-20	Buy
Usbiological	264707	Boc-4-fluoro-D-phenylalanine Asreported	57292-45-2	2g	$343	2026-06-03	Buy
Usbiological	264707	Boc-4-fluoro-D-phenylalanine Asreported	57292-45-2	5g	$582	2026-06-03	Buy
Usbiological	264707	Boc-4-fluoro-D-phenylalanine Asreported	57292-45-2	10g	$811	2026-06-03	Buy

Product number	Packaging	Price	Buy
B3303	1g	$42	Buy
B3303	5g	$166	Buy
264707	2g	$343	Buy
264707	5g	$582	Buy
264707	10g	$811	Buy

BOC-D-4-Fluorophe Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

Boc-D-4-Fluorophenylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Synthesis

24424-99-5

1132-68-9

41153-30-4

GENERAL STEPS: (S)-2-Amino-3-(4-fluorophenyl)propanoic acid (1.97 g, 10 mmol) was dissolved in a mixture of dioxane (20 mL), water (20 mL) and 1M NaOH (10 mL), stirred and cooled in an ice water bath. Di-tert-butyl dicarbonate (2.4 g, 11 mmol) was added to the reaction system, followed by continued stirring for 6 hours at room temperature. Upon completion of the reaction, the solution was concentrated under vacuum to about 15-20 mL and again cooled in an ice water bath. The concentrate was covered with ethyl acetate (~30 mL) and acidified to pH 2-3 by adding dilute KHSO4 solution. the aqueous phase was separated and extracted three times with ethyl acetate. The ethyl acetate extracts were combined and dried over anhydrous Na2SO4 followed by vacuum evaporation of the solvent. The resulting product was a waxy solid with a yield of 2.115 g (7.25 mmol, 72.5% yield). The product was characterized by 1H NMR (DMSO-d6, 400 MHz) and MALDI-TOF mass spectrometry.1H NMR data: δ 12.60 (s, 1H, COOH), 7.29-7.25 and 7.11-7.07 (m, 4H, aromatic protons), 4.10-3.00 (m, 1H, CH-4F-Phe), 3.03- 2.77 (m, 2H, CH2-4F-Phe), 1.33 (s, 9H, Boc).MALDI-TOF mass spectrometry data (matrix: α-cyano-4-hydroxycinnamic acid (CHCA)): m/z [M + H]+ 284.12 (calculated), 284.29 (observed); [M + Na]+ 306.11 (calculated), 306.25 (calculated). 306.25 (observed value).

References

[1] Chemical Communications, 2014, vol. 50, # 76, p. 11154 - 11157
[2] Patent: WO2017/42805, 2017, A1. Location in patent: Page/Page column 24; 25
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
[4] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1733 - 1745

BOC-D-4-Fluorophe Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate L-4-Fluorophenylalanine Sodium hydroxide 1,4-Dioxane Water

Preparation Products

57292-45-2 (BOC-D-4-Fluorophe ) Related Search:

tert-Butanol L-Phenylalanine EC 2.6.1.2 D-Phenylalanine D-Alanine

DL-Phenylalanine N-(tert-Butoxycarbonyl)-L-phenylalanine N-Carbobenzyloxyglycine Phenprobamate Boc-Aib-OH

Boc-Gly-Leu-OH BOC-D-4-Fluorophe Fluorine BOC-L-2-FLUOROPHE BOC-D-3-FLUOROPHE

BOC-D-2-FLUOROPHE BOC-D-3,4-Difluorophe Boc-L-3-fluorophenylalanine

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BOC-D-4-FLUOROPHE BOC-(R)-2-AMINO-3-(4'-FLUOROPHENYL)PROPANOIC ACID BOC-P-FLUORO-D-PHENYLALANINE BOC-P-FLUORO-D-PHE-OH BOC-4-FLUORO-D-PHE BOC-4-FLUORO-D-PHENYLALANINE BOC-4-FLUORO-D-PHE-OH BOC-D-PHE(P-F)-OH BOC-D-PHE(4-F)-OH (R)-N-BOC-4-FLUOROPHENYLALANINE RARECHEM BK PT 0035 tert-butoxycarbonyl-d-4-fluorophenylalanine N-ALPHA-TERT-BUTYLOXYCARBONYL-D-4-FLUOROPHENYLALANINE N-ALPHA-T-BOC-4-FLUORO-D-PHENYLALANINE N-T-BUTOXYCARBONYL-P-FLUORO-D-PHENYLALANINE N-TERT-BUTOXYCARBONYL-4-FLUOROPHENYL-D-ALANINE (R)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID (Tert-Butoxy)Carbonyl D-Phe(4-F)-OH 4-Fluoro-D-phenylalanine, N-BOC protected 95+% N-[(1,1-Dimethylethoxy)carbonyl]-4-fluoro-D-phenylalanine Boc-D-4-F-Phe (2R)-3-(4-fluorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoate BOC-D-4-FLUOROPHENYLALANINE D-4-FLUOROPHENYLALANINE, BOC PROTECTED 2-tert-Butoxycarbonylamino-3-(4-fluoro-phenyl)-propionic acid N-T-BOC-P-FLUORO-D-PHENYLALANINE N-alpha-tert-Butoxycarbonyl-3-(4-fluorophenyl)-D-al BOC-D-4-FLUOROPHENYLALANINE 98% N-tert-Butoxy-D-4-Fluoro Phenylalanine 4-Fluoro-D-phenylalanine,N-BOCprotected N-alpha-t-Butyloxycarbonyl-4-fluoro-D-phenylalanine (R)-Boc-2-amino-3-(4-fluorophenyl)propionic acid Boc-4-fluoro-D-phenylalanine99% Boc-D-Phe(4-F) -OH Boc-4-Fluoro-D-Phenylalanine N-Boc-4-fluoro-D-phenylalanine Boc-D-Phe(4-F)-OH Boc-4-fluoro-D-phenylalanine Boc-p-fluoro-D-Phe-OH N-ALPHA-T-BUTYLOXYCARBONYL-D-4-FLUOROPHENYLALANINE N-(tert-butoxycarbonyl)-p-fluoro-D-phenylalanine (R)-N-BOC-4-FLUOROPHENYLALANINE, 95%, 98% EE (R)-N-BOC-4-Fluorophenylalanine, 98% ee Boc-D-4-Fluoro-phe-OH N-Boc-4-fluoro-D-phenylalanine, 95% N-(tert-Butoxycarbonyl)-4-fluoro-D-phenylalanine > D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro- Boc-D-Phe(4-F)-OH,98% Venadaparib Impurity 71 (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid - [B90805] (2R)-3-(4-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (R)-2-((tert-Butoxycarbonyl)aMino)-3-(4-fluorophenyl)propanoic acid N-(tert-Butoxycarbonyl)-4-fluoro-D-phenylalanine 57292-45-2 C14H17FNO4 C14H18NO4F Phenylalanine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Phenylalanine analogs and other aromatic alpha amino acids