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BOC-L-2-Fluorophe

BOC-L-2-Fluorophe Structure
BOC-L-2-Fluorophe structure
CAS No.
114873-00-6
Chemical Name:
BOC-L-2-Fluorophe
Synonyms
BOC-PHE(2-F)-OH;BOC-PHE(O-F)-OH;BOC-L-2-FLUOROPHE;BOC-L-PHE(2-F)-OH;BOC-2-FLUORO-L-PHE;RARECHEM BK PT 0020;BOC-O-FLUORO-PHE-OH;(S)-BOC-2-Fluorophe;Boc-o-fluoro-L-Phe-OH;Boc-L-2-Fluoro-phe-OH
CBNumber:
CB5745883
Molecular Formula:
C14H18FNO4
Molecular Weight:
283.3
MDL Number:
MFCD00672520
MOL File:
114873-00-6.mol
MSDS File:
SDS
Last updated:2026-01-13 11:22:19
Product description Number Pack Size Price
Boc-2-fluoro-L-phenylalanine 99+% 235857 1g $170
Boc-2-fluoro-L-phenylalanine FB48027 5G $176.6
Boc-2-fluoro-L-phenylalanine 089316 5g $177
2-Fluoro-L-phenylalanine, N-BOC protected PC0232 5g $216
Boc-Phe(2-F)-OH 182761 25g $270
More product size
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BOC-L-2-Fluorophe Properties

Melting point 92-96 °C
alpha 10 º (c=1,EtOAc)
Boiling point 427.3±40.0 °C(Predicted)
Density 1.1918 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 3.87±0.11(Predicted)
form Powder
Appearance White to off-white Solid
optical activity [α]20/D +9±1°, c = 1% in ethyl acetate
BRN 5347990
Major Application peptide synthesis
InChI 1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey NTWUXBKUDXGMHV-NSHDSACASA-N
SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1F)C(O)=O
CAS DataBase Reference 114873-00-6(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H413
Precautionary statements  P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
Hazard Note  Irritant/Keep Cold
HS Code  2922498590
Storage Class 13 - Non Combustible Solids
NFPA 704
0
0 0

BOC-L-2-Fluorophe price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 235857 Boc-2-fluoro-L-phenylalanine 99+% 114873-00-6 1g $170 2021-12-16 Buy
Biosynth Carbosynth FB48027 Boc-2-fluoro-L-phenylalanine 114873-00-6 5G $176.6 2021-12-16 Buy
Matrix Scientific 089316 Boc-2-fluoro-L-phenylalanine 114873-00-6 5g $177 2021-12-16 Buy
Apolloscientific PC0232 2-Fluoro-L-phenylalanine, N-BOC protected 114873-00-6 5g $216 2021-12-16 Buy
ChemPep 182761 Boc-Phe(2-F)-OH 114873-00-6 25g $270 2021-12-16 Buy
Product number Packaging Price Buy
235857 1g $170 Buy
FB48027 5G $176.6 Buy
089316 5g $177 Buy
PC0232 5g $216 Buy
182761 25g $270 Buy

BOC-L-2-Fluorophe Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

2-FLUORO-L-PHENYLALANINE

19883-78-4

BOC-L-2-Fluorophe

114873-00-6

General steps: 1. 2-Fluoro-L-phenylalanine (1.00 g) was dissolved in a mixture of dioxane (10 ml) and water (5 ml) under cooling conditions in an ice bath. 2. 1N aqueous sodium hydroxide solution (5.46 ml) and di-tert-butyl dicarbonate (1.38 ml) were slowly added to the above solution, keeping the reaction system in an ice bath. 3. The ice bath was removed and the reaction mixture was stirred at room temperature for 1 hour. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the organic solvent. 5. The pH of the concentrate was adjusted to 2.5 with dilute hydrochloric acid. 6. 6. The aqueous phase was extracted with ethyl acetate (100 ml x 3) and the organic phases were combined. 7. Wash the organic phase with water and saturated saline in turn. 8. 8. Dry the organic phase with anhydrous sodium sulfate and filter to remove the desiccant. 9. The filtrate was concentrated under pressure to obtain the crude product. 10. The crude product was recrystallized with ethyl acetate-petroleum ether mixed solvent to obtain N-Boc-2-fluoro-L-phenylalanine (1.32 g, 85% yield) as colorless crystals.

References

[1] Patent: US5556853, 1996, A
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099

BOC-L-2-Fluorophe Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 2-FLUORO-L-PHENYLALANINE Water Sodium hydroxide

Preparation Products

BOC-L-2-Fluorophe Suppliers

Global( 193)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29826 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Honest Joy Holdings Limited 		0755-36694831 +8613717124449 sale@feiyang.com.cn China 300 58
GL Biochem(Binhai) Ltd. 		+86-021-61263370 +8615301650015 wuqiuyan@glschina.com China 2975 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
GenicBio Limited 		58
career henan chemical co 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Honest Joy Holdings Limited 		58
GL Biochem(Binhai) Ltd. 		58
Dideu Industries Group Limited 		58

View Lastest Price from BOC-L-2-Fluorophe manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-Phe(2-F)-OH pictures 2025-10-13 Boc-Phe(2-F)-OH
114873-00-6
 US $2.20-8.80 / kg 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
BOC-L-2-Fluorophe pictures 2025-04-04 BOC-L-2-Fluorophe
114873-00-6
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
BOC-L-2-Fluorophe pictures 2019-09-02 BOC-L-2-Fluorophe
114873-00-6
 US $7.00 / KG 1KG 99% JD 379 Career Henan Chemical Co
  • Boc-Phe(2-F)-OH pictures
  • Boc-Phe(2-F)-OH
    114873-00-6
  • US $2.20-8.80 / kg
  • 99%min
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

BOC-L-2-Fluorophe Spectrum

BOC-L-2-Fluorophe(114873-00-6)1HNMR

114873-00-6(BOC-L-2-Fluorophe )Related Search:

tert-Butyl acetate Phenprobamate DL-Phenylalanine EC 2.6.1.2 N-Carbobenzyloxyglycine
N-(tert-Butoxycarbonyl)-L-alanine D-Alanine D-Phenylalanine N-(tert-Butoxycarbonyl)-L-phenylalanine N-Boc-N'-nitro-L-arginine
tert-Butyl peroxyacetate Boc-Aib-OH Fmoc-Phe-OH Fmoc-Lys(Boc)-OH L-Phenylalanine
tert-Butanol BOC-L-PENTAFLUOROPHENYLALANINE (S)-N-Boc-(4-Pyridyl)alanine

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BOC-L-2-FLUOROPHE BOC-L-2-FLUOROPHENYLALANINE BOC-L-PHE(2-F)-OH BOC-O-FLUORO-PHE-OH BOC-PHE(O-F)-OH BOC-PHE(2-F)-OH BOC-(S)-2-AMINO-3-(2'-FLUOROPHENYL)PROPANOIC ACID N-TERT-BUTOXYCARBONYL-2-FLUOROPHENYL-L-ALANINE N-ALPHA-T-BUTOXYCARBONYL-L-2-FLUOROPHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-2-FLUOROPHENYLALANINE RARECHEM BK PT 0020 (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID tert-Butoxycarbonyl-L-2-fluorophenylalanine (S)-N-BOC-2-FLUOROPHENYLALANINE BOC-2-FLUORO-L-PHENYLALANINE L-2-FLUOROPHENYLALANINE, BOC PROTECTED L-2-Fluorophenylalanine, N-BOC protected N-alpha-tert-Butoxycarbonyl-3-(2-fluorophenyl)-L-al N-ALPHA-T-BUTYLOXYCARBONYL-L-2-FLUOROPHENYLALANINE (S)-N-BOC-2-FLUOROPHENYLALANINE 98+% N-tert-Butoxycarbonyl-L-Fluoro Phenylalanine 2-Fluoro-L-phenylalanine,N-BOCprotected (S)-2-((tert-Butoxycarbonyl)aMino)-3-(2-fluorophenyl)propanoic acid (S)-Boc-2-amino-3-(2-fluorophenyl)propionic acid Boc-2-fluoro-L-phenylalanine99% Boc-o-fluoro-L-Phe-OH N-Boc-L-2-fluorophenylalanine,99%e.e. (Tert-Butoxy)Carbonyl L-Phe(2-F)-OH (S)-BOC-2-Fluorophe N-alpha-t-Butyloxycarbonyl-2-fluoro-L-phenylalanine (S)-N-BOC-2-FLUOROPHENYLALANINE, 95%, 98% EE (S)-N-BOC-2-Fluorophenylalanine, 98% ee Boc-L-2-Fluoro-phe-OH BOC-2-FLUORO-L-PHE L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-2-fluoro- N-Boc-L-2-fluorophenylalanine Boc-2-Fluoro-Phe-OH (Boc-2-Fluoro-L-Phenylalanine) Boc-L-Phe(2-F) -OH Boc-2-Fluoro-L-Phenylalanine Boc-2-fluoro-L-phenylalanine Boc-o-fluoro-Phe-OH N-Boc-2-fluoro-L-phenylalanine, 98% (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(2-fluorophenyl)propanoic acid, N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine (2S)-3-(2-fluorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoate BOC-L-2-Fluorophe USP/EP/BP (2S)-3-(2-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid 114873-00-6 C14H18FNO4 Specialty Synthesis Phenylalanine Derivatives Peptide Synthesis Unnatural Amino Acid Derivatives Peptide a-amino chiral Phenylalanine analogs and other aromatic alpha amino acids Amino Acids