3-Bromo-6-chloro-2-methylpyridine
- CAS No.
- 132606-40-7
- Chemical Name:
- 3-Bromo-6-chloro-2-methylpyridine
- Synonyms
- 5-BROMO-2-CHLORO-6-METHYLPYRIDINE;2-Chloro-5-Bromo-6-Picoline;5-BROMO-2-CHLORO-6-PICOLINE;3-BROMO-6-CHLORO-2-PICOLINE;3-BROMO-6-CHLORO-2-METHYL-PYRIDINE;2-methyl -5-bromo 6-chloro pyridine;Pyridine, 3-bromo-6-chloro-2-methyl-;3-Bromo-6-chloro-2-methylpyridine>3-Bromo-6-chloro-2-methylpyridine ISO 9001：2015 REACH
- CBNumber:
- CB5673834
- Molecular Formula:
- C6H5BrClN
- Molecular Weight:
- 206.47
- MDL Number:
- MFCD07375117
- MOL File:
- 132606-40-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | <40°C |
|---|---|
| Boiling point | 80-84℃/2mm lit. |
| Density | 1.624±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| pka | -1.29±0.10(Predicted) |
| form | Liquid |
| color | White or Colorless to Light yellow |
| CAS DataBase Reference | 132606-40-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-Bromo-6-chloro-2-methylpyridine price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4405 | 3-Bromo-6-chloro-2-methylpyridine >97.0%(GC) | 132606-40-7 | 5g | $170 | 2026-04-30 | Buy |
| Usbiological | 270338 | 2-Chloro-5-bromo-6-methylpyridine Asreported | 132606-40-7 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 270338 | 2-Chloro-5-bromo-6-methylpyridine Asreported | 132606-40-7 | 5g | $463 | 2026-06-03 | Buy |
| Usbiological | 270338 | 2-Chloro-5-bromo-6-methylpyridine Asreported | 132606-40-7 | 10g | $622 | 2026-06-03 | Buy |
| Usbiological | 270338 | 2-Chloro-5-bromo-6-methylpyridine Asreported | 132606-40-7 | 25g | $832 | 2026-06-03 | Buy |
3-Bromo-6-chloro-2-methylpyridine Chemical Properties, Uses, Production
Uses
3-Bromo-6-chloro-2-methylpyridine is an organic synthetic reagent for the preparation of difluoropyridine N-oxide and its 4-nitro derivative.
Synthesis
42753-71-9
132606-40-7
General procedure for the synthesis of 5-bromo-2-chloro-6-methylpyridine from 2-amino-5-bromo-6-methylpyridine: dichloromethane (900 mL) was added to a 2L three-necked round-bottomed flask, followed by the addition of 2-amino-6-methyl-5-bromopyridine (74.23 g, 0.39 mol), pyridine hydrochloride (139 g, 1.2 mol), sodium nitrite (83.26 g, 1.2 mol) and cuprous chloride (3.76 g, 5% w/w relative to the feedstock). The reaction mixture was cooled to 0-10 °C in an ice water bath. Hydrochloric acid (4.5 mL, 6% v/w vs. feedstock) was added slowly and stirred at 0-10 °C for 30 min. The cooling bath was removed and the mixture was continued to stir at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (400 mL) and the organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (100 mL). The organic layers were combined and concentrated to dryness. Hexane (750 mL) was added to the residue and stirred. The solid was collected by filtration, washed with hexane, and the filtrate was concentrated to dryness to afford the pure product 5-bromo-2-chloro-6-methylpyridine (61 g, 70% yield) in light yellow crystalline form.
References
[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 49
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 2, p. 273 - 276
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 4, p. 569 - 574
[4] Patent: US2005/192310, 2005, A1. Location in patent: Page/Page column 36
[5] Patent: WO2011/28395, 2011, A1. Location in patent: Page/Page column 16
3-Bromo-6-chloro-2-methylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 3-Bromo-6-chloro-2-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Bromo-2-chloro-6-picoline
132606-40-7
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 3-Bromo-6-chloro-2-methylpyridine
132606-40-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 5-Bromo-2-chloro-6-methylpyridine
132606-40-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-Bromo-2-chloro-6-picoline
132606-40-7
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 3-Bromo-6-chloro-2-methylpyridine
132606-40-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromo-2-chloro-6-methylpyridine
132606-40-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
