Methyl 5-bromo-2-iodobenzoate
- CAS No.
- 181765-86-6
- Chemical Name:
- Methyl 5-bromo-2-iodobenzoate
- Synonyms
- 5-Bromo-2-iodobenzoate;5-Bromo-2-iodo-benzoic acid methyl ester;QCF4;Methyl 2-Iodo-5-Bromobenzoate;5-bromo-2-iodobenzoate methyl;Benzoic acid,5-broMo-2-iodo-, Methyl ester;Methyl 5-
broMo- 2- iodobenzoate;METHYL 5-BROMMETHYL 5-BROMO-2-IODOBENZOATEO-2-IODOBENZOATE
- CBNumber:
- CB2972909
- Molecular Formula:
- C8H6BrIO2
- Molecular Weight:
- 340.94
- MDL Number:
- MFCD00144771
- MOL File:
- 181765-86-6.mol
- MSDS File:
- SDS
| Melting point | 45-49 °C (lit.) |
|---|---|
| Boiling point | 134°C/1mmHg(lit.) |
| Density | 2.059±0.06 g/cm3(Predicted) |
| Flash point | 113℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Orange to Green |
| InChIKey | CJRHLSZJEFJDLA-UHFFFAOYSA-N |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
Methyl 5-bromo-2-iodobenzoate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 652601 | Methyl 5-bromo-2-iodobenzoate 97% | 181765-86-6 | 10g | $175 | 2026-04-30 | Buy |
| TCI Chemical | M3084 | Methyl 5-Bromo-2-iodobenzoate >95.0%(GC) | 181765-86-6 | 1g | $17 | 2026-04-30 | Buy |
| TCI Chemical | M3084 | Methyl 5-Bromo-2-iodobenzoate >95.0%(GC) | 181765-86-6 | 5g | $50 | 2026-04-30 | Buy |
| Biosynth | FM137802 | Methyl 5-bromo-2-iodobenzoate | 181765-86-6 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FM137802 | Methyl 5-bromo-2-iodobenzoate | 181765-86-6 | 50g | $900 | 2026-06-04 | Buy |
Methyl 5-bromo-2-iodobenzoate Chemical Properties, Uses, Production
Application
Methyl 5-bromo-2-iodobenzoate belongs to the benzoic acid derivatives and is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry. It can be used to prepare preservatives, dyes, and drug molecules.
Chemical Properties
off-white powder
Synthesis
610-97-9
181765-86-6
Concentrated sulfuric acid (10 mL) was added dropwise to a stirred solution of methyl 2-iodobenzoate (5.0 g, 19.08 mmol, 1.0 eq.) and N-bromosuccinimide (NBS, 3.73 g, 20.99 mmol, 1.1 eq.) in acetic acid (10 mL), keeping the reaction temperature between 20-40 °C. The reaction mixture was stirred at room temperature for 88 hours and then warmed up to 50°C and continued stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to 10 °C and the reaction was quenched with cold water (40 mL) and subsequently extracted with dichloromethane (DCM, 3 x 50 mL). The organic layers were combined and washed sequentially with 5% sodium bicarbonate solution (2 × 50 mL), 10% sodium sulfite solution (50 mL), and water (50 mL), then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the crude product methyl 5-bromo-2-iodobenzoate. The crude product was purified by rapid column chromatography on silica gel, the eluent being a hexane solution of 10% ethyl acetate. The pure grade was collected and the solvent was evaporated under reduced pressure to give methyl 5-bromo-2-iodobenzoate as an off-white solid (5 g, 77% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δppm: 3.94 (s, 3H), 7.26-7.29 (m, 1H), 7.83 (d, J=8.4 Hz, 1H), 7.93 (d, J=8.8 Hz, 1H).
References
[1] Patent: WO2018/15879, 2018, A1. Location in patent: Page/Page column 81
[2] Patent: US2004/92521, 2004, A1. Location in patent: Page/Page column 16-20; 46
[3] Patent: US2005/256118, 2005, A1. Location in patent: Page/Page column 18-19
[4] Patent: US2005/256309, 2005, A1. Location in patent: Page/Page column 20-21; 36
[5] Patent: US2005/272728, 2005, A1. Location in patent: Page/Page column 19-20
Methyl 5-bromo-2-iodobenzoate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qinyang Chuang'an Chemical Technology Co., Ltd | 61280670 15617977826 | 3007367019@qq.com | China | 305 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Methyl 5-bromo-2-iodobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | methyl 5-bromo-2-iodobenzoate
181765-86-6
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2024-06-11 | METHYL 5-BROMO-2-IODOBENZOATE
181765-86-6
|
10G | 0.98 | 500kg | Kindchem(Nanjing)Co.,Ltd | ||
 |
2020-01-01 | METHYL 5-BROMO-2-IODOBENZOATE
181765-86-6
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- methyl 5-bromo-2-iodobenzoate
181765-86-6
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- METHYL 5-BROMO-2-IODOBENZOATE
181765-86-6
- 0.98
- Kindchem(Nanjing)Co.,Ltd
-
- METHYL 5-BROMO-2-IODOBENZOATE
181765-86-6
- $1.00
- 99%
- Career Henan Chemical Co
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