2-Nitro-5-fluorobenzoic acid, methyl ester
- CAS No.
- 393-85-1
- Chemical Name:
- 2-Nitro-5-fluorobenzoic acid, methyl ester
- Synonyms
- METHYL 5-FLUORO-2-NITROBENZOATE;RARECHEM AL BF 0375;Methyl 2-nitro-5-fluorobenzoate;5-fluoro-3-methyl-2-nitrobenzoate;Methyl5-fluoro-2-nitrobenzoate98%;Methyl 5-fluoro-2-nitrobenzoate 98%;5-Fluor-2-nitrobenzoesuremethylester;3-Methoxycarbonyl-4-nitrofluorobenzene;2-Nitro-5-fluorobenzoic acid, methyl ester;5-FLUORO-2-NITRO-BENZOIC ACID METHYL ESTER
- CBNumber:
- CB6678063
- Molecular Formula:
- C8H6FNO4
- Molecular Weight:
- 199.14
- MDL Number:
- MFCD03425619
- MOL File:
- 393-85-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 40-42°C |
|---|---|
| Boiling point | 282℃ |
| Density | 1.388 |
| Flash point | 124℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone, DMSO |
| form | Low Melting Solid |
| color | White |
| Water Solubility | Slightly soluble in water. Soluble in dimethyl sulfoxide and acetone. |
| InChI | InChI=1S/C8H6FNO4/c1-14-8(11)6-4-5(9)2-3-7(6)10(12)13/h2-4H,1H3 |
| InChIKey | LCAUVFVOLNRVKG-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC(F)=CC=C1[N+]([O-])=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2916399090 | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2-Nitro-5-fluorobenzoic acid, methyl ester price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-N495885-500MG | 2-Nitro-5-fluorobenzoic Acid, Methyl Ester | 393-85-1 | 500mg | $212 | 2026-06-03 | Buy |
| TRC | TRC-N495885-2G | 2-Nitro-5-fluorobenzoic Acid, Methyl Ester | 393-85-1 | 2g | $720 | 2026-06-03 | Buy |
| TRC | TRC-N495885-1G | 2-Nitro-5-fluorobenzoic Acid, Methyl Ester | 393-85-1 | 1g | $376 | 2026-06-03 | Buy |
| Apolloscientific | PC7145 | Methyl 5-fluoro-2-nitrobenzoate >98% | 393-85-1 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC7145 | Methyl 5-fluoro-2-nitrobenzoate >98% | 393-85-1 | 25g | $39 | 2026-06-04 | Buy |
2-Nitro-5-fluorobenzoic acid, methyl ester Chemical Properties, Uses, Production
Chemical Properties
Off-White to Yellow Solid
Uses
2-Nitro-5-fluorobenzoic Acid, Methyl Ester (cas# 393-85-1) is a compound useful in organic synthesis.
Synthesis
67-56-1
320-98-9
393-85-1
4-Fluoro-2-nitrobenzoic acid (4 g, 21.6 mmol) was dissolved in 40 mL of methanol at 0 °C and 8.0 mL of concentrated sulfuric acid was slowly added. The reaction mixture was warmed to 60 °C and stirred continuously for 16 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted with aqueous potassium carbonate to 8. Subsequently, the organic solvent was evaporated under reduced pressure. The remaining aqueous phase was extracted with ethyl acetate, the organic phases were combined and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to afford the red oily product methyl 2-nitro-5-fluorobenzoate (3.6 g, 82% yield). Mass spectrometry (ESI positive ion mode): m/z = 200 [M + H]+. LC-MS analytical conditions [Method 4, gradient elution: starting solvent water (containing 0.05% trifluoroacetic acid)-acetonitrile, initial acetonitrile ratio 10%]: retention time Rt = 1.01 min.
References
[1] Patent: WO2018/172250, 2018, A1. Location in patent: Page/Page column 385-386
[2] Patent: US2010/280268, 2010, A1. Location in patent: Page/Page column 57
[3] Patent: US2010/249158, 2010, A1. Location in patent: Page/Page column 16
[4] Patent: EP1810969, 2007, A1. Location in patent: Page/Page column 58
2-Nitro-5-fluorobenzoic acid, methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2-Nitro-5-fluorobenzoic acid, methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | Methyl 5-fluoro-2-nitrobenzoate
393-85-1
|
5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2022-02-19 | 2-nitro-5-fluorobenzoic acid methyl ester
393-85-1
|
1KG | 98.7% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-07-12 | 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER
393-85-1
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Methyl 5-fluoro-2-nitrobenzoate
393-85-1
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-nitro-5-fluorobenzoic acid methyl ester
393-85-1
- $0.00
- 98.7%
- Honest Joy Holdings Limited
-
- 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER
393-85-1
- $1.00
- 99%
- Career Henan Chemical Co
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