magnolin
- CAS No.
- 31008-18-1
- Chemical Name:
- magnolin
- Synonyms
- Maglin;Magnolin;magnolitin;Magnolin-RM;magnolin, 10 mM in DMSO;Medioresinol dimethyl ether;Benzene, bis(chloromethyl)dimethyl-;Magnolin, 98%, from Magnolia liliflora Desr.;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-
- CBNumber:
- CB31335188
- Molecular Formula:
- C23H28O7
- Molecular Weight:
- 416.46
- MDL Number:
- MFCD07783722
- MOL File:
- 31008-18-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 91.4-92.9 °C |
|---|---|
| Boiling point | 536.9±50.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D +46 to +56°, c =0.5 in chloroform-d |
| InChIKey | MFIHSKBTNZNJIK-RZTYQLBFSA-N |
| SMILES | O1C[C@]2([H])[C@@H](C3=CC(OC)=C(OC)C(OC)=C3)OC[C@]2([H])[C@H]1C1=CC=C(OC)C(OC)=C1 |
| FDA UNII | 95DA2NWV8P |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
magnolin price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2438 | Magnolin ≥95% (HPLC) | 31008-18-1 | 5 mg | $69.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2438 | Magnolin ≥95% (HPLC) | 31008-18-1 | 25 mg | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 25123 | Magnolin ≥98% | 31008-18-1 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 25123 | Magnolin ≥98% | 31008-18-1 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 25123 | Magnolin ≥98% | 31008-18-1 | 10mg | $268 | 2026-04-30 | Buy |
magnolin Chemical Properties, Uses, Production
Description
Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
Chemical Properties
White crystalline powder, soluble in chloroform, derived from the flower buds of Magnolia denudata Desr., Magnoliaceae.
Uses
Magnolin is a lignan extract from Magnoliae Flos, displaying anti-asthma and anti-inflammatory activity.
in vitro
Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.
IC 50
ERK2: 16.5 nM (IC50); ERK1: 87 nM (IC50)
magnolin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 | sales@shshiji.com | China | 9531 | 55 |
View Latest Price from magnolin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | magnolin
31008-18-1
|
$36.00 | 99.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | magnolin
31008-18-1
|
1KG | 98% | 20Tons | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2024-07-29 | magnolin
31008-18-1
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
