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2'-(Trifluoromethyl)acetophenone

2'-(Trifluoromethyl)acetophenone structure

CAS No.: 17408-14-9

Chemical Name:: 2'-(Trifluoromethyl)acetophenone

Synonyms: 2-(TRIFLUOROMETHYL)ACETOPHENONE;2-ACETYLBENZOFLUORIDE;2-ACETYLBENZOTRIFLUORIDE;2-(trifluoromethyl) hypnone;O-TRIFLUOROMETHYLACETOPHENONE;2'-(trifluoromethyl)acetophenone;Acetophenone, 2'-trifluoromethyl-;2'-(Trifluoromethyl)acetophenone98%;2'-(Trifluoromethyl)acetophenone 98%;2'-(Trifluoromethyl)acetophenone,99%

CBNumber:: CB3341401

Molecular Formula:: C9H7F3O

Molecular Weight:: 188.15

MDL Number:: MFCD00000378

MOL File:: 17408-14-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:09:11

Product description	Number	Pack Size	Price
2′-(Trifluoromethyl)acetophenone 99%	233153	5g	$31.1
2'-(Trifluoromethyl)acetophenone >98.0%(GC)	T1899	5g	$64
2'-(Trifluoromethyl)acetophenone	FT64543	25g	$900
2'-(Trifluoromethyl)acetophenone	FT64543	250g	$900
2'-(Trifluoromethyl)acetophenone	FT64543	100g	$900
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2'-(Trifluoromethyl)acetophenone Properties

Melting point	15-17°C
Boiling point	163 °C
Density	1.255 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4584(lit.)
Flash point	184 °F
storage temp.	2-8°C
form	Liquid
Specific Gravity	1.255
color	Clear colorless to very slightly yellow
BRN	2259035
InChI	1S/C9H7F3O/c1-6(13)7-4-2-3-5-8(7)9(10,11)12/h2-5H,1H3
InChIKey	FYDUUODXZQITBF-UHFFFAOYSA-N
SMILES	CC(=O)c1ccccc1C(F)(F)F
CAS DataBase Reference	17408-14-9(CAS DataBase Reference)
NIST Chemistry Reference	2'-(Trifluoromethyl)acetophenone(17408-14-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-24/25-36

WGK Germany

HazardClass

IRRITANT

HS Code

29143990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

2'-(Trifluoromethyl)acetophenone price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	233153	2′-(Trifluoromethyl)acetophenone 99%	17408-14-9	5g	$31.1	2026-04-30	Buy
TCI Chemical	T1899	2'-(Trifluoromethyl)acetophenone >98.0%(GC)	17408-14-9	5g	$64	2026-04-30	Buy
Biosynth	FT64543	2'-(Trifluoromethyl)acetophenone	17408-14-9	25g	$900	2026-06-04	Buy
Biosynth	FT64543	2'-(Trifluoromethyl)acetophenone	17408-14-9	250g	$900	2026-06-04	Buy
Biosynth	FT64543	2'-(Trifluoromethyl)acetophenone	17408-14-9	100g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
233153	5g	$31.1	Buy
T1899	5g	$64	Buy
FT64543	25g	$900	Buy
FT64543	250g	$900	Buy
FT64543	100g	$900	Buy

2'-(Trifluoromethyl)acetophenone Chemical Properties,Uses,Production

Chemical Properties

clear colorless to very slightly yellow liqui

Uses

2′-(Trifluoromethyl)acetophenone has been used to investigate the use of in situ generated CuCF₃ for the direct substitution of chlorine by CF₃ in various aromatic substrates.

Synthesis

79756-81-3

17408-14-9

The general procedure for the synthesis of o-trifluoromethylacetophenone using 1-(2-trifluoromethylphenyl)ethanol as starting material was as follows: in a round-bottomed flask, which was pre-dried in an oven, eosin Y (5 mmol), 1-(2-trifluoromethylphenyl)ethanol (1 mmol), and 3 equiv. of TBHP (5.5 M solution in decane, with the solvent being dry acetonitrile (ACN) were added. The resulting mixture was degassed for 15 min and subsequently backfilled with nitrogen. Next, the mixture was irradiated at room temperature (25 °C) using a blue LED lamp (12 W, 455 nm). The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with 15 mL of 10% NaHCO3 solution and extracted with ethyl acetate (EtOAc, 3 × 20 mL). The organic extracts were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. Finally, the crude product was purified by silica gel column chromatography using ethyl acetate:hexane as eluent to obtain the target product o-trifluoromethyl acetophenone.

References

[1] ChemCatChem, 2015, vol. 7, # 12, p. 1865 - 1870
[2] Tetrahedron Letters, 2016, vol. 57, # 30, p. 3294 - 3297
[3] Green Chemistry, 2017, vol. 19, # 2, p. 474 - 480

2'-(Trifluoromethyl)acetophenone Preparation Products And Raw materials

Raw materials

-METHYL-2-TRIFLUOROMETHYLBENZYL ALCOHOL Methylmagnesium chloride 2-Bromobenzotrifluoride Acetic anhydride 2-Chlorobenzotrifluoride

2-(Trifluoromethyl)benzoyl chloride Decane Molecular sieve 3A Acid Red 87 tert-Butyl hydroperoxide

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Preparation Products

4,4,4-TRIFLUORO-1-(2-TRIFLUOROMETHYLPHENYL)-1,3-BUTANEDIONE

2'-(Trifluoromethyl)acetophenone Suppliers

Global( 243)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5838	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2971	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5597	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
Fuxin Pharmaceutical	58

View Lastest Price from 2'-(Trifluoromethyl)acetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	2'-(Trifluoromethyl)acetophenone 17408-14-9		1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2021-07-02	2"-(Trifluoromethyl)acetophenone 17408-14-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	2'-(Trifluoromethyl)acetophenone 17408-14-9	$1.00	1KG	98%-100%	1	Career Henan Chemical Co

2'-(Trifluoromethyl)acetophenone
17408-14-9
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

2"-(Trifluoromethyl)acetophenone
17408-14-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2'-(Trifluoromethyl)acetophenone
17408-14-9
$1.00
98%-100%
Career Henan Chemical Co

2'-(Trifluoromethyl)acetophenone Spectrum

2'-(Trifluoromethyl)acetophenone(17408-14-9)MS 2'-(Trifluoromethyl)acetophenone(17408-14-9)¹HNMR 2'-(Trifluoromethyl)acetophenone(17408-14-9)¹³CNMR 2'-(Trifluoromethyl)acetophenone(17408-14-9)IR1 2'-(Trifluoromethyl)acetophenone(17408-14-9)IR2 2'-(Trifluoromethyl)acetophenone(17408-14-9)IR3 2'-(Trifluoromethyl)acetophenone(17408-14-9)Raman

17408-14-9(2'-(Trifluoromethyl)acetophenone)Related Search:

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2-ACETYLBENZOFLUORIDE 2-ACETYLBENZOTRIFLUORIDE O-TRIFLUOROMETHYLACETOPHENONE 1-[2-(Trifluoromethyl)phenyl]ethanone Acetophenone, 2'-trifluoromethyl- Ethanone, 1-[2-(trifluoromethyl)phenyl]- 2-(trifluoromethyl) hypnone 2'-(Trifluoromethyl)acetophenone 98% 2'-(Trifluoromethyl)acetophenone98% 1-[2-(trifluoromethyl)phenyl]ethan-1-one 2'-(Trifluoromethyl)acetophenone, 97+% 2'-(Trifluoromethyl)acetophenone,99% 2'-(trifluoromethyl)acetophenone 2′-(Trifluoromethyl)acetophenone, CAS 17408-14-9 2-(TRIFLUOROMETHYL)ACETOPHENONE 17408-14-9 C9H7OF3 C9H7F3O C9H7F30 Ketones Organic Building Blocks KETONE Building Blocks Carbonyl Compounds C9 Fluorine series Benzenes C9 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) Boronic Acid series Fluorobenzene Carbonyl Compounds