2-Trifluoromethyl-6-pyridinecarboxylic acid
- CAS No.
- 131747-42-7
- Chemical Name:
- 2-Trifluoromethyl-6-pyridinecarboxylic acid
- Synonyms
- 6-(TRIFLUOROMETHYL)PICOLINIC ACID;6-TRIFLUOROMETHYLPYRIDINE-2-CARBOXYLIC ACID;2-Trifluoromethyl-6-pyridinecarb;2-Trifluoromethyl-6-pyridinecarboxylic;2-Trifluoromethyl-6-pyridinecarboxylic aci;2-TRIFLUOROMETHYL-6-PYRIDINECARBOXYLIC ACID;6-TrifluoroMethyl-2-pyridinecarboxylic acid;2-Carboxylic acid-6-trifluoromethylpyridine;6-(trifluoroMethyl)pyridin-2-carboxylic acid;2-（Trifluoromethyl）pyridine-6-carboxylic acid
- CBNumber:
- CB9252727
- Molecular Formula:
- C7H4F3NO2
- Molecular Weight:
- 191.11
- MDL Number:
- MFCD02180819
- MOL File:
- 131747-42-7.mol
- MSDS File:
- SDS
| Melting point | 154-158 °C |
|---|---|
| Boiling point | 263.0±40.0 °C(Predicted) |
| Density | 1.484±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Solid |
| pka | 3.21±0.10(Predicted) |
| color | Off-white |
| InChI | InChI=1S/C7H4F3NO2/c8-7(9,10)5-3-1-2-4(11-5)6(12)13/h1-3H,(H,12,13) |
| InChIKey | OKBHXGBLXDNJJD-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC(C(F)(F)F)=CC=C1 |
| CAS DataBase Reference | 131747-42-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Trifluoromethyl-6-pyridinecarboxylic acid price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 739804 | 6-(Trifluoromethyl)pyridine-2-carboxylic acid 97% | 131747-42-7 | 1g | $108 | 2026-04-30 | Buy |
| TCI Chemical | T3270 | 6-(Trifluoromethyl)-2-pyridinecarboxylic Acid >98.0%(GC)(T) | 131747-42-7 | 1g | $73 | 2026-04-30 | Buy |
| Apolloscientific | PC8969 | 6-(Trifluoromethyl)pyridine-2-carboxylic acid 98% | 131747-42-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC8969 | 6-(Trifluoromethyl)pyridine-2-carboxylic acid 98% | 131747-42-7 | 5g | $28 | 2026-06-04 | Buy |
| SynQuest Laboratories | 4H21-3-Z3 | 6-(Trifluoromethyl)pyridine-2-carboxylic acid 97% | 131747-42-7 | 25g | $195 | 2026-05-22 | Buy |
2-Trifluoromethyl-6-pyridinecarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
A useful organic intermediate.
Synthesis
124-38-9
189278-27-1
131747-42-7
General procedure for the synthesis of 6-(trifluoromethyl)pyridine-2-carboxylic acid from carbon dioxide and 2-bromo-6-trifluoromethylpyridine: 1. 2-Bromo-6-(trifluoromethyl)pyridine (100 mg, 0.44 mmol, 1 eq.) was dissolved in anhydrous ether at room temperature and protected by nitrogen and subsequently cooled to -70 °C. 2. 1.6 M hexane solution of n-butyllithium (0.28 mL, 0.44 mmol, 1 eq.) was added slowly and dropwise through the addition funnel. 3. The reaction mixture was stirred at -40 °C for 15 minutes and then cooled to -70 °C again. 4. Carbon dioxide gas was introduced into the reaction mixture and continuously bubbled for 10 minutes. 5. Allow the reaction mixture to warm slowly to room temperature. 6. 6. the reaction was terminated by addition of water and subsequently washed three times with ether. 7. Adjust the pH of the aqueous layer to 3 with concentrated hydrochloric acid. 8. Extracted the acidic aqueous layer with ethyl acetate three times. 9. The ethyl acetate layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 6-(trifluoromethyl)pyridine-2-carboxylic acid (30 mg) as a white solid in 35% yield. 10. The product was detected by LCMS and the molecular ion peak (M + H)+ = 192.06 was confirmed.
References
[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 36
2-Trifluoromethyl-6-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Changzhou Run-chem Biotech Co., ltd | 15061933924 | 3301839366@qq.com | China | 932 | 58 |
| Fuxin Custchem Fine Chemical Co., Ltd. | 0418-5113999 18740177324 | sales@custchem.com.cn | China | 448 | 58 |
| Hainan Huaxiang Pharmaceutical Technology Co., Ltd. | -- | bug521@163.com | China | 825 | 58 |
| Fuxin Yuke Chemical Technology Co., Ltd. | 0418-6696667 15724496333 | 2630398044@qq.com | China | 181 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 2-Trifluoromethyl-6-pyridinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Trifluoromethyl-6-pyridinecarboxylic acid
131747-42-7
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Trifluoromethyl-6-pyridinecarboxylic acid
131747-42-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2024-03-28 | 6-(Trifluoromethyl)picolinic acid
131747-42-7
|
25kg | 98% | PNP Biotech Co. Ltd |
-
- 2-Trifluoromethyl-6-pyridinecarboxylic acid
131747-42-7
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Trifluoromethyl-6-pyridinecarboxylic acid
131747-42-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-(Trifluoromethyl)picolinic acid
131747-42-7
- $0.00
- 98%
- PNP Biotech Co. Ltd
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