6-Chloro-2-picolinic acid methyl ester
- CAS No.
- 6636-55-1
- Chemical Name:
- 6-Chloro-2-picolinic acid methyl ester
- Synonyms
- methyl 6-chloropicolinate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;methyl 6-chloro-2-pyridinecarboxylate;AKOS BBS-00004651;Sorafenib Impurity 117;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;2-chloropyridine-6-carboxylate methyl;6-chloro-2-picolonic acid methyl ester;methyl 2-(6-chloropyridin-2-yl)acetate
- CBNumber:
- CB3780710
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00155391
- MOL File:
- 6636-55-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 93-94° |
|---|---|
| Boiling point | 275.8±20.0 °C(Predicted) |
| Density | 1.294±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.03±0.10(Predicted) |
| form | Solid |
| color | Pale yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3 |
| InChIKey | TWUXBVMXSBEKHA-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(Cl)=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
6-Chloro-2-picolinic acid methyl ester price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | 6636-55-1 | 1g | $18 | 2026-04-30 | Buy |
| TCI Chemical | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | 6636-55-1 | 5g | $22 | 2026-04-30 | Buy |
| Usbiological | 284730 | Methyl 6-chloro-2-pyridinecarboxylate Asreported | 6636-55-1 | 2g | $337 | 2026-06-03 | Buy |
| Usbiological | 284730 | Methyl 6-chloro-2-pyridinecarboxylate Asreported | 6636-55-1 | 5g | $499 | 2026-06-03 | Buy |
| Usbiological | 284730 | Methyl 6-chloro-2-pyridinecarboxylate Asreported | 6636-55-1 | 10g | $679 | 2026-06-03 | Buy |
6-Chloro-2-picolinic acid methyl ester Chemical Properties, Uses, Production
Uses
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867
Synthesis
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2004/26871, 2004, A1. Location in patent: Page 43
[2] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47
[3] Patent: WO2013/102431, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2015/6592, 2015, A1. Location in patent: Page/Page column 52; 53
6-Chloro-2-picolinic acid methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Xinrui Pharmaceutical Technology Co., Ltd. | 0573-82750556 13616838856 | 1062740657@qq.com | China | 109 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 6-Chloro-2-picolinic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-08 | Methyl 6-chloropicolinate
6636-55-1
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 6-chloropicolinate
6636-55-1
- 99%
- Jinan Ruitong Biotech Co., Ltd.
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