6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CAS No.
- 6636-55-1
- Chemical Name:
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- Synonyms
- AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CBNumber:
- CB3780710
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00155391
- MOL File:
- 6636-55-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | M2640 | 1g | $16 |
| Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | M2640 | 5g | $31 |
| 6-Chloro-2-picolinicacidmethylester | C379663 | 500mg | $65 |
| 6-Chloro-2-picolinicacidmethylester | C379663 | 100mg | $45 |
| Methyl 6-chloro-2-pyridinecarboxylate 95+% | 048113 | 5g | $23 |
| More product size | |||
| Melting point | 93-94° |
|---|---|
| Boiling point | 275.8±20.0 °C(Predicted) |
| Density | 1.294±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.03±0.10(Predicted) |
| form | Solid |
| color | Pale yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3 |
| InChIKey | TWUXBVMXSBEKHA-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(Cl)=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
6-CHLORO-2-PICOLINIC ACID METHYL ESTER price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | 6636-55-1 | 1g | $16 | 2025-07-31 | Buy |
| TCI Chemical | M2640 | Methyl 6-Chloro-2-pyridinecarboxylate >98.0%(GC) | 6636-55-1 | 5g | $31 | 2025-07-31 | Buy |
| TRC | C379663 | 6-Chloro-2-picolinicacidmethylester | 6636-55-1 | 500mg | $65 | 2021-12-16 | Buy |
| TRC | C379663 | 6-Chloro-2-picolinicacidmethylester | 6636-55-1 | 100mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 048113 | Methyl 6-chloro-2-pyridinecarboxylate 95+% | 6636-55-1 | 5g | $23 | 2021-12-16 | Buy |
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867
Synthesis
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2004/26871, 2004, A1. Location in patent: Page 43
[2] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47
[3] Patent: WO2013/102431, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2015/6592, 2015, A1. Location in patent: Page/Page column 52; 53
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3977 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10240 | 58 |
View Lastest Price from 6-CHLORO-2-PICOLINIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-08-29 | Methyl 6-chloropicolinate
6636-55-1
|
US $0.00-0.00 / kg | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | |
 |
2025-04-04 | 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- Methyl 6-chloropicolinate
6636-55-1
- US $0.00-0.00 / kg
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
6636-55-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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