5-Bromo-2,4-difluoroaniline
- CAS No.
- 452-92-6
- Chemical Name:
- 5-Bromo-2,4-difluoroaniline
- Synonyms
- BUTTPARK 100\01-17;2,4-DIFLUORO-5-BROMOANILINE;3-BROMO-4,6-DIFLUOROANILINE;5-Bromo-2,4-difluoroaniline;5-Bromo-2,4-difluorobenzenamine;5-Bromo-2,4-difluoroaniline 99%;5-BROMO-2,4-DIFLUORO-PHENYLAMINE;Benzenamine, 5-bromo-2,4-difluoro-;5-BROMO-2,4-DIFLUOROANILINE ISO 9001：2015 REACH
- CBNumber:
- CB9195024
- Molecular Formula:
- C6H4BrF2N
- Molecular Weight:
- 208
- MDL Number:
- MFCD03426368
- MOL File:
- 452-92-6.mol
- MSDS File:
- SDS
| Melting point | 25-29 °C (lit.) |
|---|---|
| Boiling point | 223℃ |
| Density | 1.788 |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | 2.19±0.10(Predicted) |
| form | solid |
| Appearance | Off-white to brown Solid |
| InChI | 1S/C6H4BrF2N/c7-3-1-6(10)5(9)2-4(3)8/h1-2H,10H2 |
| InChIKey | FQZCUAASVCIWSL-UHFFFAOYSA-N |
| SMILES | Nc1cc(Br)c(F)cc1F |
| CAS DataBase Reference | 452-92-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T,Xi |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Hazard Note | Toxic/Irritant |
| HazardClass | IRRITANT |
| HS Code | 29214200 |
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
5-Bromo-2,4-difluoroaniline price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 56889 | 5-BROMO-2,4-DIFLUORO-PHENYLAMINE 98% | 452-92-6 | 1G | $23 | 2026-04-30 | Buy |
| AstaTech | 56889 | 5-BROMO-2,4-DIFLUORO-PHENYLAMINE 98% | 452-92-6 | 5G | $47 | 2026-04-30 | Buy |
| Apolloscientific | PC9925 | 5-Bromo-2,4-difluoroaniline 98% | 452-92-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC9925 | 5-Bromo-2,4-difluoroaniline 98% | 452-92-6 | 25g | $41 | 2026-06-04 | Buy |
| Activate Scientific | AS35887 | 5-Bromo-2,4-difluoroaniline 98% | 452-92-6 | 5g | $19 | 2026-06-04 | Buy |
5-Bromo-2,4-difluoroaniline Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
5-Bromo-2,4-difluoroaniline is an organic compound commonly used in pharmaceutical research and organic synthesis.
Synthesis
345-24-4
452-92-6
General procedure for the synthesis of 2,4-difluoro-5-bromoaniline from 2,4-difluoro-5-bromonitrobenzene: In a 250 mL round-bottomed flask, 5-bromo-2,4-difluoro nitrobenzene (5.04 g, 21.3 mmol), saturated ammonium chloride solution (25.0 mL), iron powder (5.00 g, 89.5 mmol), ethanol (100 mL), tetrahydrofuran (50.0 mL), and water (25.0 mL), and refluxed at 95 °C for 1.5 hours. Upon completion of the reaction, it was cooled to room temperature, saturated sodium bicarbonate solution (100 mL) was added, and the mixture was filtered through diatomaceous earth and the diatomaceous earth was washed with ethyl acetate (3 x 50 mL). The combined filtrates were washed sequentially with water and brine, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast chromatography (ethyl acetate: hexane = 1:9) to afford 5-bromo-2,4-difluoroaniline (2.61 g, 59.1% yield).1H NMR (400 MHz, CDCl3) δ 6.97 (dd, 1H, J = 7.2, 6.7 Hz), 6.85 (t, 1H, J = 8.2 Hz), 3.63 (br, 2H) .
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3870 - 3882
[2] Patent: WO2004/5257, 2004, A1. Location in patent: Page 67-68
[3] Journal of the American Chemical Society, 1956, vol. 78, p. 2593,2596
5-Bromo-2,4-difluoroaniline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
View Latest Price from 5-Bromo-2,4-difluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-BROMO-2,4-DIFLUOROANILINE
452-92-6
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 5-BROMO-2,4-DIFLUOROANILINE
452-92-6
- $1.00
- 99%
- Career Henan Chemical Co
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