2-Mercaptonicotinic acid
- CAS No.
- 38521-46-9
- Chemical Name:
- 2-Mercaptonicotinic acid
- Synonyms
- 2-sulfanylpyridine-3-carboxylic acid;2-Mercaptonicotinic;2-MERCAPTOPYRIDINE-3-CARBOXYLIC ACID;TIMTEC-BB SBB000123;2-THIONICOTINIC ACID;Mercaptonicotinicaci;LABOTEST-BB LT01596005;2-MERCAPTOCOTINIC ACID;2-mercaptonitinic acid;2-Mercaptonicotinicaci
- CBNumber:
- CB4378840
- Molecular Formula:
- C6H5NO2S
- Molecular Weight:
- 155.17
- MDL Number:
- MFCD00010102
- MOL File:
- 38521-46-9.mol
- MSDS File:
- SDS
| Melting point | 263-265 °C(lit.) |
|---|---|
| Boiling point | 295.3±50.0 °C(Predicted) |
| Density | 1.357 (estimate) |
| refractive index | 1.5380 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 1.98±0.20(Predicted) |
| form | crystalline (fine) |
| color | yellow |
| Sensitive | Air Sensitive |
| BRN | 119029 |
| InChI | InChI=1S/C6H5NO2S/c8-6(9)4-2-1-3-7-5(4)10/h1-3H,(H,7,10)(H,8,9) |
| InChIKey | WYKHFQKONWMWQM-UHFFFAOYSA-N |
| SMILES | C1(=S)NC=CC=C1C(O)=O |
| CAS DataBase Reference | 38521-46-9(CAS DataBase Reference) |
| FDA UNII | EU7D859ABZ |
| EPA Substance Registry System | 2-Mercaptonicotinic acid (38521-46-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
2-Mercaptonicotinic acid price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 419702 | 2-Mercaptopyridine-3-carboxylic acid technical grade | 38521-46-9 | 25g | $72.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 419702 | 2-Mercaptopyridine-3-carboxylic acid technical grade | 38521-46-9 | 100g | $192 | 2026-04-30 | Buy |
| TCI Chemical | M1213 | 2-Mercaptonicotinic Acid | 38521-46-9 | 25g | $51 | 2026-04-30 | Buy |
| Biosynth | FM00951 | 2-Mercaptonicotinic acid | 38521-46-9 | 0.25kg | $900 | 2026-06-04 | Buy |
| Biosynth | FM00951 | 2-Mercaptonicotinic acid | 38521-46-9 | 0.1kg | $900 | 2026-06-04 | Buy |
2-Mercaptonicotinic acid Chemical Properties, Uses, Production
Chemical Properties
yellow powder
Uses
2-Mercaptopyridine-3-carboxylic acid may be used for the synthesis of poly[[diaquabis([μ]2-4,4 ′-bipyridyl)iron(II)] bis{2-[(3-carboxypyridin-2-yl)disulfanyl]nicotinate}] and 2-(2-carboxyethylthio)nicotinic acid.
Reactions
2-Mercaptonicotinic acid is prone to decomposition and deterioration at high temperatures, it can undergo nucleophilic substitution reactions under the action of alkaline substances.
Hazard
2-Mercaptonicotinic acid is a flammable liquid and vapor, it causes severe skin burns and eye damage and may cause respiratory irritation.
Synthesis
2942-59-8
38521-46-9
The general procedure for the synthesis of 2-mercaptonicotinic acid from 2-chloronicotinic acid was as follows: a suspension of 2-chloronicotinic acid (790 mg, 5 mmol) and thiourea (457 mg, 6 mmol) was suspended in water (15 mL) and the reaction was carried out at reflux for 8 h at 90 °C. Upon completion of the reaction, the mixture was cooled to room temperature to obtain a pale yellow suspension. Subsequently, the pH was adjusted to about 8 with dilute hydrochloric acid and stirred for 10 minutes to precipitate 2-mercaptonicotinic acid as a pale yellow solid. The solid was separated by filtration and dried to give the target product 2-mercaptonicotinic acid (590 mg, 84% yield).
References
[1] Patent: CN103626693, 2016, B. Location in patent: Paragraph 0157-0159
[2] Roczniki Chemii, 1932, vol. 12, p. 493,495
[3] Chem. Zentralbl., 1932, vol. 103, # II, p. 3400
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 3908,3910
2-Mercaptonicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang C-element Biotech Co.,Ltd | +86-18033710157 18033710157 | Lisa@C-elementBiotech.com | China | 234 | 58 |
| Shijiazhuang Dowell Chemical Co., Ltd | 0311-89805679 17692413312 | sell@dowechem.com | China | 60 | 62 |
| Shijiazhuang Coshine Chemical Co.,Ltd | 18633820607 18633820607 | 377964081@qq.com | China | 94 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
View Latest Price from 2-Mercaptonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 2-Mercaptonicotinic acid
38521-46-9
|
$10.00-50.00 | 10g | 0.98 | 10kg | Shanghai UCHEM Inc. | |
 |
2026-08-20 | 2-Mercaptonicotinic acid
38521-46-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-05-23 | 2-Mercaptonicotinic acid
38521-46-9
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 2-Mercaptonicotinic acid
38521-46-9
- $10.00-50.00
- 0.98
- Shanghai UCHEM Inc.
-
- 2-Mercaptonicotinic acid
38521-46-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Mercaptonicotinic acid
38521-46-9
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
