5,6-Dichloronicotinic acid
- CAS No.
- 41667-95-2
- Chemical Name:
- 5,6-Dichloronicotinic acid
- Synonyms
- 2,3-dichloropyridine-5-carboxylic acid;5,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID;5,6-DichL;5,6-Dichloro;TIMTEC-BB SBB003623;Avatrhopal Impurity 45;5,6-DICHLORONICOTINIC A;Avatrombopag Impurity 10;5,6-Dichloronicotinicaci;Avatroposide impurities16
- CBNumber:
- CB5261891
- Molecular Formula:
- C6H3Cl2NO2
- Molecular Weight:
- 192
- MDL Number:
- MFCD00075181
- MOL File:
- 41667-95-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 164-168 °C(lit.) |
|---|---|
| Boiling point | 342.1±37.0 °C(Predicted) |
| Density | 1.612±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 2.87±0.10(Predicted) |
| form | Powder |
| color | White to beige to tan |
| BRN | 383740 |
| InChI | InChI=1S/C6H3Cl2NO2/c7-4-1-3(6(10)11)2-9-5(4)8/h1-2H,(H,10,11) |
| InChIKey | RNRLTTNKVLFZJS-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=C(Cl)C=C1C(O)=O |
| CAS DataBase Reference | 41667-95-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
5,6-Dichloronicotinic acid price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 340219 | 5,6-Dichloropyridine-3-carboxylic acid 96% | 41667-95-2 | 5g | $26 | 2023-06-20 | Buy |
| TCI Chemical | D2401 | 5,6-Dichloronicotinic Acid >98.0%(T) | 41667-95-2 | 5g | $42 | 2026-04-30 | Buy |
| TCI Chemical | D2401 | 5,6-Dichloronicotinic Acid >98.0%(T) | 41667-95-2 | 25g | $143 | 2026-04-30 | Buy |
| TRC | TRC-D435653-500MG | 5,6-Dichloronicotinic acid | 41667-95-2 | 500mg | $59 | 2026-06-03 | Buy |
| AstaTech | CL0206 | 5,6-DICHLORONICOTINICACID 97% | 41667-95-2 | 5G | $10 | 2026-04-30 | Buy |
5,6-Dichloronicotinic acid Chemical Properties, Uses, Production
Chemical Properties
white to off-white crystalline powder
Uses
5,6-Dichloronicotinic acid is a dihalonicotinic acid. It is used in the preparation of 5-chloro-6-iodonicotinic acid by iodine displacement.
Application
5,6-Dichloronicotinic acid is a compound that can be synthesized by reacting methyl ketones with chloroacetic acid. It is used in the synthesis of maleic anhydride and has been shown to inhibit the catalysis of acetylcholine chloride. It has also been shown to have an inhibitory effect on Alzheimer's disease. The kinetic mechanism for this inhibition occurs through the hydrolysis step of 5,6-Dichloronicotinic acid by magnesium chloride in hexane solution. The reactive acylation reaction proceeds when it reacts with acetic anhydride in the presence of pyridine.
Synthesis
401566-69-6
41667-95-2
The general procedure for the synthesis of 5,6-dichloropyridine-3-carboxylic acid from 5,6-dichloronicotinic acid ethyl ester was as follows: in a solvent mixture of tetrahydrofuran (THF), methanol (MeOH) and water (50 mL, 4:1:1, v/v/v), ethyl 5,6-dichloronicotinic acid ethyl ester (1.0 g, 4.5 mmol) and aqueous sodium hydroxide 2N solution (6.75 mL, 13.5 mmol). The reaction mixture was stirred at room temperature for 0.5 hours. Upon completion of the reaction, the mixture was concentrated to remove the organic solvent. Subsequently, the mixture was acidified with 2N hydrochloric acid to a pH of about 2. The acidified mixture was extracted with ether (30 mL x 3). The organic layers were combined, washed with water (50 mL x 3), dried over anhydrous sodium sulfate, and concentrated to give 5,6-dichloropyridine-3-carboxylic acid (800 mg, 91% yield) as a white solid.LCMS (ESI) m/z: 192.0 [M + H]+.
References
[1] Patent: US2013/317000, 2013, A1. Location in patent: Paragraph 0368-0369
5,6-Dichloronicotinic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Crest Biotechnology Co. Ltd. | 13062833949 | fred.wen@crcorporation.cn | China | 853 | 58 |
| Shandong Xuande Pharmaceutical Technology Co. LTD | 18866895588 | dingjiaying@shiningpharm.com | China | 184 | 55 |
| Shanghai GaoLang Chemical Technology Co., Ltd. | 021-57340939 18017297327;18916191449 | sales@gaolangchemical.com | China | 49 | 55 |
| ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD | 18957127338 | sales@zetchem.com | China | 500 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
View Latest Price from 5,6-Dichloronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-03 | 5,6-Dichloronicotinic acid
41667-95-2
|
1kg | ≥98% by HPLC | 50kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. | ||
 |
2026-09-02 | 5,6-Dichloronicotinic acid
41667-95-2
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 5,6-Dichloronicotinic acid
41667-95-2
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 5,6-Dichloronicotinic acid
41667-95-2
- ≥98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- 5,6-Dichloronicotinic acid
41667-95-2
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5,6-Dichloronicotinic acid
41667-95-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
