6-Aminonicotinic acid
- CAS No.
- 3167-49-5
- Chemical Name:
- 6-Aminonicotinic acid
- Synonyms
- 2-AMINO-5-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 6-amino-;6-AMINOPYRIDINE-3-CARBOXYLIC ACID;6- aMinoacid;6-AMinonicotinic a;TIMTEC-BB SBB004186;RARECHEM AL BO 1167;6-Aminonicotinc Acid;6-AMINONICOTINIC ACID;Nicotinic acid, 6-amino-
- CBNumber:
- CB9449781
- Molecular Formula:
- C6H6N2O2
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00006326
- MOL File:
- 3167-49-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 253.51°C (rough estimate) |
| Density | 1.3471 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.86±0.10(Predicted) |
| form | Powder |
| color | White to beige |
| Water Solubility | ca 1.0 g/L (20 ºC) |
| Merck | 14,456 |
| BRN | 115992 |
| InChI | InChI=1S/C6H6N2O2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H2,7,8)(H,9,10) |
| InChIKey | ZCIFWRHIEBXBOY-UHFFFAOYSA-N |
| SMILES | C1=NC(N)=CC=C1C(O)=O |
| CAS DataBase Reference | 3167-49-5(CAS DataBase Reference) |
| FDA UNII | 9VR2O1OK60 |
| NIST Chemistry Reference | Nicotinic acid, 6-amino-(3167-49-5) |
| EPA Substance Registry System | 3-Pyridinecarboxylic acid, 6-amino- (3167-49-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-23/24/25 | |||||||||
| Safety Statements | 22-24/25-45-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
6-Aminonicotinic acid price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 216879 | 6-Aminopyridine-3-carboxylic acid 97% | 3167-49-5 | 5g | $49.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 216879 | 6-Aminopyridine-3-carboxylic acid 97% | 3167-49-5 | 1g | $24.9 | 2023-06-20 | Buy |
| TCI Chemical | A1486 | 6-Aminonicotinic Acid >98.0%(T) | 3167-49-5 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | A1486 | 6-Aminonicotinic Acid >98.0%(T) | 3167-49-5 | 5g | $122 | 2026-04-30 | Buy |
| Usbiological | A1379-13 | 6-Aminonicotinic Acid (6-Amino-3-pyridinecarboxylic Acid) | 3167-49-5 | 1g | $355 | 2026-06-03 | Buy |
6-Aminonicotinic acid Chemical Properties, Uses, Production
Chemical Properties
Light yellow Cryst
Uses
6-Aminopyridine-3-carboxylic acid (6-Aminonicotinic acid) was used in the preparation of resin-bound 2-aminoazine.
Uses
Antiproliferative
Application
6-Aminonicotinic acid is an inhibitor of bacterial DNA gyrase and topoisomerase IV. It has been shown to inhibit the growth of a number of bacteria, including E. coli K-12, with potent inhibitory activity against these enzymes. It binds to the active sites on these enzymes and prevents them from working. The detection time for 6-aminonicotinic acid is about 3 hours after exposure. It has been shown to be more potent than other inhibitors of bacterial DNA gyrase and topoisomerase IV such as 2,4-diaminopyrimidine (2,4DAP).
Definition
ChEBI: An aminonicotinic acid in which the amino group is situated at position 6 of the pyridine ring.
General Description
Electrosynthesis of 6-aminopyridine-3-carboxylic acid (6-aminonicotinic acid) by electrochemical reduction of 2-amino-5-bromo and 2-amino-5-chloropyridine in the presence of CO2 at silver electrode has been reported.
Synthesis
Using 2-amino-5-methylpyridine as the starting material, it was first reacted with triethylamine and acetyl chloride in dichloromethane at 30 °C for 5 h; the product was washed with water, dried and concentrated to obtain 2-acetamido-5-methylpyridine with a yield of 90%. Then, it was reacted with 30% hydrogen peroxide at 85 °C for 16 h under the catalysis of sodium dodecylbenzene sulfonate and γ-aluminum oxide; the product was washed with water, suction-filtered and dried to obtain 6-acetamidonicotinic acid with a yield of 91%. Finally, it was reacted with aqueous sodium hydroxide solution at 80 °C for 12 h, the pH was adjusted to 3 with 6 M hydrochloric acid, and the resulting solid was suction-filtered and dried to obtain 6-aminonicotinic acid with a yield of 92%.
Purification Methods
Crystallise the acid from aqueous acetic acid. Dry it in vacuo at 70o. [Beilstein 22 III/IV 6726.]
6-Aminonicotinic acid Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fama Shijiazhuang Fine Chemical Co., Ltd. | 0311-88800819 13932107110 | sales@jztchem.com | China | 14 | 62 |
| Hangzhou Chemtrue Bio-Tech Co.,Ltd. | 19967494293 | sales@chemtrue-bio.com | China | 303 | 58 |
| NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD. | 025-86819868 13951004015 | sales@jinchemical.com | China | 26 | 58 |
| Shijiazhuang Dowell Chemical Co., Ltd | 0311-89805679 17692413312 | sell@dowechem.com | China | 60 | 62 |
| Changzhou Share Chemical Co., Ltd | 0519-82619998 | wu@sharechem.com | China | 29 | 54 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 6-Aminonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 6-Aminonicotinic acid
3167-49-5
|
1kg | 99% | 1 | Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd. | ||
 |
2026-09-07 | 6-Aminonicotinic acid
3167-49-5
|
1kg | 99%min | 20tons | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
 |
2026-09-02 | 6-Aminonicotinic acid
3167-49-5
|
$1.40-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd |
-
- 6-Aminonicotinic acid
3167-49-5
- $0.00
- 99%
- Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
-
- 6-Aminonicotinic acid
3167-49-5
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- 6-Aminonicotinic acid
3167-49-5
- $1.40-32.00
- 99%
- Henan Fengda Chemical Co., Ltd
