4-THIOURACIL
- CAS No.
- 591-28-6
- Chemical Name:
- 4-THIOURACIL
- Synonyms
- KC 135;4-thiouracyl;4-THIOURACIL;4-Thiouracil97%;Uracil, 4-thio-;4-Thiouracil 97%;4-Thiouracil ,98%;4-mercaptopyrimidin-2-ol;4-Thioxo-1H-pyrimidin-2-one;2-HYDROXY-4-MERCAPTOPYRIMIDINE
- CBNumber:
- CB4469328
- Molecular Formula:
- C4H4N2OS
- Molecular Weight:
- 128.15
- MDL Number:
- MFCD00090842
- MOL File:
- 591-28-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 295 °C (dec.) (lit.) |
|---|---|
| Density | 1.368 (estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | 1 M NaOH: soluble50mg/mL |
| pka | 5.38±0.20(Predicted) |
| form | Powder |
| color | Yellow |
| InChI | InChI=1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8) |
| InChIKey | OVONXEQGWXGFJD-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC(=S)N1 |
| CAS DataBase Reference | 591-28-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-THIOURACIL price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 440736 | 4-Thiouracil 97% | 591-28-6 | 1g | $115 | 2026-04-30 | Buy |
| TCI Chemical | T2757 | 4-Thiouracil >97.0%(HPLC)(T) | 591-28-6 | 1g | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 500mg | $60 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 1g | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 5g | $423 | 2026-04-30 | Buy |
4-THIOURACIL Chemical Properties,Uses,Production
Description
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.
Chemical Properties
yellow powder
Uses
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
Uses
4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
Synthesis Reference(s)
Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906
References
[1] MICHAEL R MILLER. TU-tagging: cell type–specific RNA isolation from intact complex tissues[J]. Nature Methods, 2009, 6 6: 439-441. DOI: 10.1038/nmeth.1329
[2] XIAORAN ZOU. Photophysical and Photochemical Properties of 4-Thiouracil: Time-Resolved IR Spectroscopy and DFT Studies[J]. The Journal of Physical Chemistry B, 2014, 118 22: 5864-5872. DOI: 10.1021/jp501658a
[3] GUSTI M ZEINER. RNA analysis by biosynthetic tagging using 4-thiouracil and uracil phosphoribosyltransferase.[J]. Methods in molecular biology, 2008, 419: 135-146. DOI: 10.1007/978-1-59745-033-1_9
4-THIOURACIL Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Tianhong Medicine Chemical Technology Co.,Ltd. | 18949937116 | dongye.huaxue@126.com | China | 143 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Lastest Price from 4-THIOURACIL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-15 | 4-Thiouracil
591-28-6
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 4-THIOURACIL
591-28-6
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 4-Thiouracil
591-28-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-THIOURACIL
591-28-6
- $1.00
- 98%
- Career Henan Chemical Co
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