4-THIOURACIL
- CAS No.
- 591-28-6
- Chemical Name:
- 4-THIOURACIL
- Synonyms
- KC 135;4-thiouracyl;4-THIOURACIL;4-Thiouracil97%;Uracil, 4-thio-;4-Thiouracil 97%;4-Thiouracil ,98%;4-mercaptopyrimidin-2-ol;4-Thioxo-1H-pyrimidin-2-one;2-HYDROXY-4-MERCAPTOPYRIMIDINE
- CBNumber:
- CB4469328
- Molecular Formula:
- C4H4N2OS
- Molecular Weight:
- 128.15
- MDL Number:
- MFCD00090842
- MOL File:
- 591-28-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Thiouracil 97% | 440736 | 1g | $115 |
| 4-Thiouracil >97.0%(HPLC)(T) | T2757 | 1g | $124 |
| 4-Thiouracil ≥98% | 16952 | 500mg | $60 |
| 4-Thiouracil ≥98% | 16952 | 1g | $97 |
| 4-Thiouracil ≥98% | 16952 | 5g | $423 |
| More product size | |||
| Melting point | 295 °C (dec.) (lit.) |
|---|---|
| Density | 1.368 (estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | 1 M NaOH: soluble50mg/mL |
| pka | 5.38±0.20(Predicted) |
| form | Powder |
| color | Yellow |
| InChI | InChI=1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8) |
| InChIKey | OVONXEQGWXGFJD-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC(=S)N1 |
| CAS DataBase Reference | 591-28-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-THIOURACIL price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 440736 | 4-Thiouracil 97% | 591-28-6 | 1g | $115 | 2026-04-30 | Buy |
| TCI Chemical | T2757 | 4-Thiouracil >97.0%(HPLC)(T) | 591-28-6 | 1g | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 500mg | $60 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 1g | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 16952 | 4-Thiouracil ≥98% | 591-28-6 | 5g | $423 | 2026-04-30 | Buy |
4-THIOURACIL Chemical Properties,Uses,Production
Description
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.
Chemical Properties
yellow powder
Uses
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
Uses
4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
Synthesis Reference(s)
Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906
References
[1] MICHAEL R MILLER. TU-tagging: cell type–specific RNA isolation from intact complex tissues[J]. Nature Methods, 2009, 6 6: 439-441. DOI: 10.1038/nmeth.1329
[2] XIAORAN ZOU. Photophysical and Photochemical Properties of 4-Thiouracil: Time-Resolved IR Spectroscopy and DFT Studies[J]. The Journal of Physical Chemistry B, 2014, 118 22: 5864-5872. DOI: 10.1021/jp501658a
[3] GUSTI M ZEINER. RNA analysis by biosynthetic tagging using 4-thiouracil and uracil phosphoribosyltransferase.[J]. Methods in molecular biology, 2008, 419: 135-146. DOI: 10.1007/978-1-59745-033-1_9
4-THIOURACIL Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3975 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1804 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49934 | 58 |
View Lastest Price from 4-THIOURACIL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-15 | 4-Thiouracil
591-28-6
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 4-THIOURACIL
591-28-6
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 4-Thiouracil
591-28-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-THIOURACIL
591-28-6
- $1.00
- 98%
- Career Henan Chemical Co
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