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N-Boc-propargylamine

N-Boc-propargylamine structure

CAS No.: 92136-39-5

Chemical Name:: N-Boc-propargylamine

Synonyms: tert-butyl prop-2-yn-1-ylcarbaMate;tert-butyl N-(prop-2-yn-1-yl)carbaMate;tert-butyl prop-2-ynylcarbaMate;tert-butyl N-prop-2-ynylcarbamate;N-Boc-proparg;N-Boc-propargyL;N-boc-aminopropyne;Boc-propargylamine;N-Boc-propargylamine;N-Boc-2-propyn-1-amine

CBNumber:: CB4500977

Molecular Formula:: C8H13NO2

Molecular Weight:: 155.19

MDL Number:: MFCD07367245

MOL File:: 92136-39-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

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N-Boc-propargylamine Properties

Melting point	40-44 °C
Boiling point	170°C/14mmHg(lit.)
Density	0.990±0.06 g/cm3(Predicted)
Flash point	93°(199°F)
storage temp.	2-8°C
solubility	Soluble in chloroform.
pka	11.24±0.46(Predicted)
form	Solid
color	Pale Yellow to Dark Yellow
Sensitive	Moisture Sensitive
InChI	InChI=1S/C8H13NO2/c1-5-6-9-7(10)11-8(2,3)4/h1H,6H2,2-4H3,(H,9,10)
InChIKey	DSPYCWLYGXGJNJ-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCC#C
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38-52/53

Safety Statements

26-36/37-61

WGK Germany

HS Code

2924297099

NFPA 704

	0
2		0

N-Boc-propargylamine price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	687146	N-Boc-propargylamine 97%	92136-39-5	5g	$109	2025-07-31	Buy
TCI Chemical	B4472	N-(tert-Butoxycarbonyl)propargylamine >98.0%(GC)	92136-39-5	1g	$22	2025-07-31	Buy
TCI Chemical	B4472	N-(tert-Butoxycarbonyl)propargylamine >98.0%(GC)	92136-39-5	5g	$69	2025-07-31	Buy
TRC	B664260	N-Boc-propargylamine	92136-39-5	25g	$325	2021-12-16	Buy
Usbiological	263853	N-Boc-Propargylamine	92136-39-5	1g	$329	2021-12-16	Buy

Product number	Packaging	Price	Buy
687146	5g	$109	Buy
B4472	1g	$22	Buy
B4472	5g	$69	Buy
B664260	25g	$325	Buy
263853	1g	$329	Buy

N-Boc-propargylamine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Low Melting Solid

Uses

N-Boc-propargylamine is used in the preparation of triazolobenzylidene-thiazolopyrimidines which act as CDC25 phosphatase inhibitors. Also used in the synthesis of β-glucan polysaccharide analogs.

Uses

N-Boc-propargylamine is used to prepare triazolobenzylidene-thiazolopyrimidines. which act as CDC25 phosphatase inhibitors. Further, it is used for the synthesis of beta-glucan polysaccharide analogs. In addition to this, it is involved in the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine to prepare 4,5-disubstituted cyclopentenones .

Synthesis

24424-99-5

2450-71-7

92136-39-5

Di-tert-butyl dicarbonate (17.5 g, 80.0 mmol, 1.0 eq.) was slowly added dropwise to a dichloromethane solution (160 mL) of propargylamine (5.49 mL, 80.0 mmol, 1.0 eq.) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h before the solvent was removed by distillation under reduced pressure. The resulting colorless oil was dried overnight under high vacuum to afford N-Boc-aminopropargyl (12.4 g, quantitative yield) as a white solid, which can be used in subsequent reactions without further purification. The spectral data of the product were consistent with those reported in the literature: Rf = 0.38 (hexane/ethyl acetate, 9:1); melting point = 41-42 °C (literature value:[1] 40-44 °C).1H NMR (500 MHz, CDCl3): δ (ppm) 4.94 (broad peak, 1H), 3.91 (broad double peak, J = 2.5 Hz, 2H), 2.23 (triple peak, J = 2.5 Hz, 1H). 2.5Hz, 1H), 1.45 (single peak, 9H).13C NMR (126MHz, CDCl3): δ (ppm) 155.2, 80.1, 79.9, 71.1, 28.2.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 17, p. 2199 - 2202
[2] Organic Letters, 2014, vol. 16, # 9, p. 2430 - 2433
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 32, p. 7091 - 7113
[4] Patent: US2004/254231, 2004, A1
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 6, p. 1338 - 1341

N-Boc-propargylamine synthesis

Synthesis of N-Boc-propargylamine from Di-tert-butyl dicarbonate and Propargyl bromide

N-Boc-propargylamine Preparation Products And Raw materials

Raw materials

Propargylamine hydrochloride BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE Propargyl bromide Di-tert-butyl dicarbonate PROPARGYLAMINE

Carbonochloridic acid, 1,1-diMethylethyl ester tert-Butyl carbamate Carbonic acid, bis(1,1-dimethylethyl) ester Dimethyl (1-Diazo-2-oxopropyl)phosphonate

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Preparation Products

ethyl 5-(tert-butoxycarbonylamino)pent-3-ynoate [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester 3-BROMO-5-(N-BOC)AMINOMETHYLISOXAZOLE

N-Boc-propargylamine Suppliers

Global( 227)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from N-Boc-propargylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	N-Boc-propargylamine 92136-39-5	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2021-07-13	N-Boc-propargylamine 92136-39-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	N-Boc-propargylamine 92136-39-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

N-Boc-propargylamine
92136-39-5
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

N-Boc-propargylamine
92136-39-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Boc-propargylamine
92136-39-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Boc-propargylamine Spectrum

N-Boc-propargylamine(92136-39-5)¹HNMR

92136-39-5(N-Boc-propargylamine)Related Search:

Propargyl bromide N-BOC-piperidine-4-carboxylic acid Diazomethane Methyl propiolate Bis(2-ethylhexyl)amine

Aniline 3-Chloropropyne Propiolic Acid 3-Amino-1,2-propanediol :(S)-2-Methyl-3-(2-propynyl)-4-oxocyclopent-2-enyl-(lR)-cis,trans-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate

PROPARGYLAMINE Ethyl propiolate DI-TERT-BUTYL ETHER Propargyl alcohol rich-d-t-Prallethrin

N-Boc-propargylamine

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N-prop-2-ynylcarbamic acid tert-butyl ester N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98%N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98%N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98% N-(tert-Butoxycarbonyl)propargyl amine N-Boc-propargylamine (2-Propynyl)carbamic acid tert-butyl ester N-(2-Propynyl)-carbamic acid tert-butyl ester N-(2-Propynyl)carbamic acid tert-butyl ester N-Propargylcarbamic acid tert-butyl ester Propargylcarbamic acid tert-butyl ester N-(tert-butyloxy)carbonyl propargylamine Carbamic acid, 2-propynyl-, 1,1-dimethylethyl ester (9CI) tert-butyl N-(prop-2-yn-1-yl)carbaMate tert-butyl prop-2-yn-1-ylcarbaMate CarbaMic acid, N-2-propyn-1-yl-, 1,1-diMethylethyl ester tert-butyl prop-2-ynylcarbaMate N-Boc-propargyl-1-aMine N-Boc-propargylaMine 97% N-Boc-2-propyn-1-amine tert-butyl N-prop-2-ynylcarbamate N-boc-aminopropyne N-(tert-Butoxycarbonyl)propargylamine> N-Boc-proparg N-Boc-propargyL tert-Butyl 2-Propynylcarbamate Boc-propargylamine N-2-Propyn-1-yl-carbamic acid tert-butyl ester N-Boc-propargylamine N-Boc-prop-2-ynylamine 98% N-(tert-Butoxycarbonyl)propargylamine - [B2432] 92136-39-5 92316-39-5 API intermediates Nitrogen Compounds Organic Building Blocks Protected Amines N-BOC Miscellaneous