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Ro 3306

Ro 3306 Structure
Ro 3306 structure
CAS No.
872573-93-8
Chemical Name:
Ro 3306
Synonyms
CS-770;Ro 3306;RO3306;RO 3306;Ro 3306 USP/EP/BP;Ro-3306, 10 mM in DMSO;Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor;5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone;(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one;(Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one;4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
CBNumber:
CB92535693
Molecular Formula:
C18H13N3OS2
Molecular Weight:
351.45
MDL Number:
MFCD17392573
MOL File:
872573-93-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
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Ro 3306 Properties

Boiling point 569.1±60.0 °C(Predicted)
Density 1.41
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear
pka 3.99±0.10(Predicted)
form powder
color white to light brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI 1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChIKey XOLMRFUGOINFDQ-YBEGLDIGSA-N
SMILES O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

Ro 3306 price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0569 RO-3306 ≥98% (HPLC) 872573-93-8 5mg $156 2026-04-30 Buy
Sigma-Aldrich SML0569 RO-3306 ≥98% (HPLC) 872573-93-8 25mg $645 2026-04-30 Buy
TCI Chemical R0201 RO-3306 872573-93-8 10MG $127 2023-01-07 Buy
TCI Chemical R0201 RO-3306 872573-93-8 50MG $378 2023-01-07 Buy
Cayman Chemical 15149 Ro 3306 ≥95% 872573-93-8 1mg $41 2026-04-30 Buy
Product number Packaging Price Buy
SML0569 5mg $156 Buy
SML0569 25mg $645 Buy
R0201 10MG $127 Buy
R0201 50MG $378 Buy
15149 1mg $41 Buy

Ro 3306 Chemical Properties, Uses, Production

Description

RO-3306 (872573-93-8) is a selective inhibitor of CDK1 (IC50= 35 nM versus CDK2 IC50= 340nM).1,2It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP inhibitors in treating various breast cancers.3,4It has also been demonstrated to overcome apoptotic resistance in BRAFV600Ehuman colorectal cancer cells.5

Uses

RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors.

Uses

RO-3306 has been used:

  • To study the significance of CA4-mediated cytotoxicity in mitotic arrest
  • In cell cycle synchronization to conduct a study on proteomics
  • As a CDK1 inhibitor, to prevent early mitotic entry

Biochem/physiol Actions

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

IC 50

CDK1: 20 nM (Ki); CDK1/cyclinB1: 35 nM (Ki); CDK1/cyclin A: 110 nM (Ki); CDK2/cyclinE: 340 nM (Ki); PKCδ: 318 nM (Ki); SGK: 497 nM (Ki); ERK: 1980 nM (Ki)

storage

Store at +4°C

References

[1] LYUBOMIR T VASSILEV. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006: 10660-10665. DOI:10.1073/pnas.0600447103
[2] LILIANA KRASINSKA  Daniel F  Emilie Cot. Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle.[J]. Cell Cycle, 2008: 1702-1708. DOI:10.4161/cc.7.12.6101
[3] AISLING PIERCE. Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines.[J]. Cancer Biology & Therapy, 2013, 14 6: 537-545. DOI:10.4161/cbt.24349
[4] QING XIA. The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.[J]. International journal of oncology, 2014, 44 3: 735-744. DOI:10.3892/ijo.2013.2240
[5] PENG ZHANG. Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.[J]. Molecular Cancer Research, 2018, 16 3: 378-389. DOI:10.1158/1541-7786.mcr-17-0404

Ro 3306 Preparation Products And Raw materials

Raw materials

Preparation Products

Ro 3306 Suppliers

Global Suppliers ( 156)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2853 52
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
Shanghai Witofly Chemical Co.,Ltd 52
Nanjing Dulai Biotechnology Co., Ltd. 55
Guangzhou Isun Pharmaceutical Co., Ltd 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Bide Pharmatech Ltd. 60
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
AdooQ Bioscience CHINA 60

View Latest Price from Ro 3306 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ro-3306 pictures 2026-08-19 Ro-3306
872573-93-8
 $30.00-88.00 99.84% 10g TargetMol Chemicals Inc.
Ro 3306 pictures 2026-06-30 Ro 3306
872573-93-8
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- pictures 2019-12-24 4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-
872573-93-8
 $1.00 1KG Min98% HPLC Career Henan Chemical Co
  • Ro-3306 pictures
  • Ro-3306
    872573-93-8
  • $30.00-88.00
  • 99.84%
  • TargetMol Chemicals Inc.
  • Ro 3306 pictures
  • Ro 3306
    872573-93-8
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd

Ro 3306 Spectrum

Ro 3306(872573-93-8)1HNMR

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Ro 3306 2-[[(Thiophen-2-yl)methyl]amino]-5-[1-(quinolin-6-yl)meth-(Z)-ylidene]thiazol-4-one (Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one (5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone RO3306;RO 3306 4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)- (5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one CS-770 Ro 3306 USP/EP/BP Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor Ro-3306, 10 mM in DMSO 872573-93-8 Inhibitors