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ChemicalBook >> CAS DataBase List >>4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Structure
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid structure
CAS No.
71675-87-1
Chemical Name:
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
Synonyms
4-AMINO-5-(ETHYLSULFONYL)-2-METHOXYBENZOIC ACID;AMisulpride Acid;Amisulpride EP Impurity E;4-Amino-5-(ethylsulphonyl)-o-anisic acid;2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID;Ami acid;Amidic acid;4-Amino-5-ethylsulfo...;4-Amino-5-(ethylsulfonyl);4-Amino-5-(ethylsulphonyl)-2-methox
CBNumber:
CB4763363
Molecular Formula:
C10H13NO5S
Molecular Weight:
259.28
MDL Number:
MFCD04973619
MOL File:
71675-87-1.mol
MSDS File:
SDS
Last updated:2026-06-12 08:45:15
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4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Properties

Melting point 82-85°C
Boiling point 529.6±50.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 4.09±0.10(Predicted)
color White to buff coloured powder
Water Solubility 8.555g/L at 25℃
Major Application pharmaceutical small molecule
InChI InChI=1S/C10H13NO5S/c1-3-17(14,15)9-4-6(10(12)13)8(16-2)5-7(9)11/h4-5H,3,11H2,1-2H3,(H,12,13)
InChIKey OJVNCXHGGYYOPH-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC(S(CC)(=O)=O)=C(N)C=C1OC
LogP 0.46
CAS DataBase Reference 71675-87-1(CAS DataBase Reference)
FDA UNII QE5K498QLP

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HazardClass  IRRITANT
HS Code  29225090
REACH Registrations Active

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2615 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid >98.0%(HPLC)(T) 71675-87-1 1g $27 2026-04-30 Buy
TCI Chemical A2615 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic Acid >98.0%(HPLC)(T) 71675-87-1 5g $122 2026-04-30 Buy
Usbiological 281778 2-Methoxy-4-amino-5-ethylsulfonyl benzoic acid Asreported 71675-87-1 100g $460 2026-06-03 Buy
Usbiological 281778 2-Methoxy-4-amino-5-ethylsulfonyl benzoic acid Asreported 71675-87-1 250g $638 2026-06-03 Buy
Usbiological 281778 2-Methoxy-4-amino-5-ethylsulfonyl benzoic acid Asreported 71675-87-1 500g $885 2026-06-03 Buy
Product number Packaging Price Buy
A2615 1g $27 Buy
A2615 5g $122 Buy
281778 100g $460 Buy
281778 250g $638 Buy
281778 500g $885 Buy

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Chemical Properties,Uses,Production

Chemical Properties

Slightly Pink Solid

Uses

An impurity found in amisulpride (A633250). Amisulpride EP Impurity E

Flammability and Explosibility

Not classified

Synthesis

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

1119455-01-4

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

71675-87-1

The general procedure for the synthesis of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid using amisulpride impurity 4 as a starting material was as follows: 30% hydrogen peroxide was slowly added to isopropanol (4.84 L) at ambient temperature containing a catalytic amount of sodium tungstate (0.0082 kg) in 4-amino-2-methoxy-5-ethylthiomethyl benzoate (X) (1.21 kg) solution. The reaction mixture was stirred at 40-45 °C for 3-4 hours and subsequently cooled to 5-10 °C. To the reaction mixture, 5% sodium thiosulfate solution (0.06 kg dissolved in 18.15 L of water) was added and stirring was continued for 60 min to produce methyl 2-methoxy-4-amino-5-ethylsulfonylbenzoate (XI) in situ. Subsequently, sodium hydroxide (1.00 kg dissolved in 10 L of water) was added to the reaction mixture, warmed to 60-65 °C and stirred for 2-3 hours. Upon completion of the reaction, the reaction material was cooled and the pH was adjusted to 4.0-4.5 with dilute hydrochloric acid (1:10). the product was isolated by diafiltration in 82% yield and 99% purity.

References

[1] Patent: WO2011/158084, 2011, A1. Location in patent: Page/Page column 12
[2] Patent: WO2011/158084, 2011, A1

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid synthesis

1119455-01-4
71675-87-1
Synthesis of 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid from methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate Water Hydrochloric acid Sodium hydroxide Isopropyl alcohol
Hydrogen peroxide

1of2

Preparation Products

Amisulpride

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Suppliers

Global( 419)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Jiecheng Pharmaceutical Co., Ltd 0531-83130525 18560095177 lily.chen@jiechengpharm.com China 25 58
Shanghai jing Hao pharmaceutical technology co., LTD 021-68900963 15618693615 sales@jinghaopharma.com China 300 58
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd. 18606289633 15862625988 sales@clentchem.com China 244 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Shandong Jiecheng Pharmaceutical Co., Ltd 58
Shanghai jing Hao pharmaceutical technology co., LTD 58
Zhangjiagang Free Trade Zone Kailite Chemical Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Adamas Reagent, Ltd. 59

View Lastest Price from 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid pictures 2026-09-13 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
71675-87-1
 0.99 RongNa Biotechnology Co.,Ltd
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid pictures 2026-08-20 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
71675-87-1
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid pictures 2026-06-30 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
71675-87-1
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd

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2-methoxyl-4-amine-5-ethylsulfonylbenzoic acid 4-AMINO-5-ETHANESULFONYL-2-METHOXY-BENZOIC ACID 2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID 2-methoxy-4-amino-5-ethysulfonyl benzoic acid 2-METHOXY-4-AMINO-5-ETHYLSULFAMOYL BENZOIC ACID BENZOICACID,4-AMINO-5-(ETHYLSULFONYL)-2-METHOXY 2-Methoxyl-4-amino-5-ethylsulfonylbenzoic acid Amisulpride Impurity 5（Amisulpride EP Impurity E) Amidic acid 4-Amino-5-(ethylsulphonyl)-2- methoxybenzoic Acid 4-Amino-5-ethylsulfo... AMisulpride iMpurity (2-Methoxy-4-aMino-5-ethylsulfonylbenzoic Acid) 2-Methoxy-4-aMino-5-ethylsulphonyl benzoic acid Ami acid 4-Amino-5-(ethylsulfonyl) 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 2-METHOXY-4-AMINO-5-ETHYLSULFONYLBENZOIC ACID 4-AMINO-5-ETHYLSULFONYL-2-METHOXYBENZOIC ACID(AMISULPIRIDE INTERMEDIATES) 4 - AMINO - 2 - METHOXY - 5 – ETHYL SULFONYL BENZOIC ACID (71675-87-1) 4-Amino-5-(ethylsulphonyl)-2-methox 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoicaci 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid ISO 9001：2015 REACH 4-Amino-2-Methoxy-5-Ethyl?Sulfonyl?Benzoic?Acid Amisulpride EP Impurity EQ: What is Amisulpride EP Impurity E Q: What is the CAS Number of Amisulpride EP Impurity E Q: What is the storage condition of Amisulpride EP Impurity E 4-Amino-5-ethylsulfonyl-2-methoxybenzoicacid (ASP-V) 4-Amino-5-ethylsulfonyl-2-methoxybenz e . 4-a mi no-5-(e th ylsulf onyl)-2-me th oxyb e nzoi c a c i d , 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid (AMI ACID) 4-Amino-5-(Ethylsulfonyl)-2-Methoxybenzoic Acid 4--2--5- Amisulpride Acid 4-Amino-5-Ethylsulfonyl-2-Methoxybenzoic Acid 4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic acid(Amic acid) 2-Methoxy-4-amino-5-ethylsulfonylbenzoic acid(Amic acid) 4-AMINO-5-(ETHYLSULFONYL)-2-METHOXYBENZOIC ACID 4-Amino-5-(ethylsulphonyl)-o-anisic acid AMisulpride Acid Amisulpride EP Impurity E 71675-87-1 C10H13NO5S API intermediates Aromatics Compounds Amines Aromatics Sulfur & Selenium Compounds Organic acids